Results 281 to 290 of about 91,213 (314)

The Need to Promote Olfactory Health in Public Health Agendas Across the Globe

Clinical Otolaryngology, EarlyView.
ABSTRACT Background A good sense of smell is essential for physical and mental health, and social wellbeing; however, across the globe, regardless of the setting, national public health agendas never consider smell health. This review aims to summarise the wide‐reaching impact of smell health in public health. Methods Narrative review of the literature
Carl Martin Philpott, Thomas Hummel, Valentina Parma, Matt Lechner, Duncan Boak, Marianna Obrist   +5 more
wiley   +1 more source

Co-infection with two α-synuclein strains reveals novel synergistic interactions. [PDF]

Acta Neuropathol
Holec SAM, Khedmatgozar CR, Schure SJ, Bartz JC, Woerman AL.   +4 more
europepmc   +1 more source

Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease

, 2015
James M. Gruschus
openalex   +2 more sources

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Clearance Pathways for α-Synuclein in Parkinson's Disease. [PDF]

J Neurochem
Ho MS.
europepmc   +1 more source

Protein tandem repeats that produce frameshifts can generate new structural states and functions

The FEBS Journal, EarlyView.
We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli, Gudrun Aldrian, Jeremy Leclercq, Theo Falgarone, Santiago M. Gómez Bergna, Denis N. Prada Gori, Andrew V. Oleinikov, Ilham Shahmuradov, Andrey V. Kajava   +8 more
wiley   +1 more source

Backtracking α-synuclein pathology: social deficits precede motor symptoms in Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Marino G, Campanelli F, Natale G, De Carluccio M, Servillo F, Nutarelli S, Caristo ME, Viscomi MT, Ghiglieri V, Calabresi P.   +9 more
europepmc   +1 more source

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau

The FEBS Journal, EarlyView.
E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki, Wataru Onodera, Akihiko Takashima, Kotaro Kawasaki, Kazuki Imadegawa, Hikaru Kurahashi, Mizuho Oishi, Toru Asahi, Yoshiyuki Soeda   +8 more
wiley   +1 more source

Ferroptosis inhibition protects against α-synuclein-related neuronal cell death. [PDF]

Cell Death Dis
Majerníková N, Caiado MJ, Seinstra RI, Couzijn S, Goya ME, Salinas CS, Truong H, van der Sluis T, Miedema A, van Kempen LCLT, McColl G, Nollen EAA, Dolga AM, den Dunnen WFA.   +13 more
europepmc   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, EarlyView.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source