Results 71 to 80 of about 779,152 (196)
, 2019 This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia.
Camylla Vilas Boas Figueiredo (6954548) +41 more
core +1 more source
Deletional a-thalassemia 1 gene detection and hematological analysis in carrier with β-thalassemia
Journal of Associated Medical Sciences, 2012 There are high prevalence of β-thalassemia and α-thalassemia in the upper Northern Thailand. Thus, the interaction between β-thalassemia and α-thalassemia can be occurred.
Sitthichai Panyasai
doaj
Application of third-generation sequencing technology in the genetic testing of thalassemia
Molecular CytogeneticsThalassemia is an autosomal recessive genetic disorder and a common form of Hemoglobinopathy. It is classified into α-thalassemia and β-thalassemia. This disease is mainly prevalent in tropical and subtropical regions, including southern China.
Weihao Li, Yanchou Ye
doaj +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This study compared Premier Resolution HPLC with Capillary Electrophoresis for detecting HbCS/Hb Paksé variants and coexisting thalassemia mutations. Premier Resolution HPLC demonstrated superior performance with 50% fewer false negative cases (11 vs. 22) compared to Capillary Electrophoresis, particularly in heterozygous cases.
Surada Satthakarn +2 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This nationwide registry‐based study describes the clinical and molecular characteristics of 78 patients with transfusion‐dependent beta‐thalassemia in Spain. Comprehensive genetic analysis revealed marked molecular heterogeneity, with 24 HBB mutations identified and a predominance of β0 genotypes, alongside generally effective transfusion and iron ...
Ana Villegas +41 more
wiley +1 more source
Alpha-Thalassemia: Diversity of Clinical Phenotypes and Update on the Treatment
Thalassemia Reports, 2022 One of the more common single-gene disorders worldwide is α-thalassemia, carriers of which are found at variable frequencies (>1%) across all tropical and subtropical countries.
Duantida Songdej, Suthat Fucharoen
doaj +1 more source
International Journal of Engineering and Technology, 2019 The problems in genome and proteome classification of mutations causing a thalassemia are synthesis, e.g. which thalassemia's database will choose? and then the technique that used in biomining to classify mutations causing thalassemia who can say is effective/optimal.
openaire +1 more source
Elevated Hemoglobin A2: A Molecular Revisited, and Implications to β‐Thalassemia Screening
Journal of Clinical Laboratory Analysis, EarlyView.In Thailand, the Hb A2 cut‐off value for β‐thalassemia carrier has been changed from 4.0% to 3.6% since 2015. We examined the molecular basis of β‐thalassemia in a large cohort of Thai subjects with this change. The molecular basis of β‐thalassemia was updated, and a change in the Hb A2 cut‐off can alter this spectrum.
Kritsada Singha +8 more
wiley +1 more source
α-Thalassemia, mental retardation, and myelodysplastic syndrome.
, 2012 This article describes three rare syndromes in which the presence of α-thalassemia provided an important clue to the molecular basis of the underlying condition.
Gibbons, Richard, Gibbons, RJ
core +1 more source
Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells [PDF]
, 2023 Alpha-thalassemia is an autosomal recessive disease with increasing worldwide prevalence. The molecular basis is due to mutation or deletion of one or more duplicated α-globin genes, and disease severity is directly related to the number of allelic ...
Yin, Han +13 more
core +1 more source