Results 61 to 70 of about 1,044,639 (194)

Thalassemia intermedia in HbH-CS disease with compound heterozygosity for β-thalassemia: challenges in hemoglobin analysis and clinical diagnosis [PDF]

, 2009
Co-inheritance of α-thalassemia with homozygosity or compound heterozygosity for β-thalassemia may ameliorate β-thalassemia major. A wide range of clinical phenotypes is produced depending on the number of α-thalassemia alleles (-α/αα --/αα, --/-α).
Tan, Mary Anne Jin Ai, George, Elizabeth, Wee, Yong Chui, Kok, Juan Loong, Tan, Kim Lian   +4 more
core   +1 more source

Deletional a-thalassemia 1 gene detection and hematological analysis in carrier with β-thalassemia

Journal of Associated Medical Sciences, 2012
There are high prevalence of β-thalassemia and α-thalassemia in the upper Northern Thailand. Thus, the interaction between β-thalassemia and α-thalassemia can be occurred.
Sitthichai Panyasai
doaj  

Alpha-Thalassemia: Diversity of Clinical Phenotypes and Update on the Treatment

Thalassemia Reports, 2022
One of the more common single-gene disorders worldwide is α-thalassemia, carriers of which are found at variable frequencies (>1%) across all tropical and subtropical countries.
Duantida Songdej, Suthat Fucharoen
doaj   +1 more source

Phenotypic and Genotypic Analysis of Two Rare Cases of ‐‐SEA/‐α4.3 HbH Disease

Journal of Clinical Laboratory Analysis, EarlyView.
We report two unrelated adult patients with rare deletional HbH disease (genotype ‐‐SEA/‐α4.3). This novel 4.3 kb deletion covering the HBA1 gene is accompanied by X‐Y‐Z segment recombination, which was identified by CycloneSEQ long‐read nanopore sequencing.
Weijia Yang, Xiaoyan Huang, Li Zhang, Xiaoqin Yang, Yaya Guo, Qingping Kang, Min Dou, Guijun Huang   +7 more
wiley   +1 more source

Genetic and Clinical Characteristics of Thalassemia Trait and Construction of LASSO‐Based Model for Its Differentiating From Iron Deficiency Anemia in Northern China

Journal of Clinical Laboratory Analysis, EarlyView.
This study revealed a β‐thalassemia‐trait‐dominated genetic spectrum in Northern‐Chinese patients with microcytic hypochromic anemia, with _αSEA/αα, HBB:c.316_197C>T and HBB:c.124_127delTTCT being the most prevalent α‐ and β‐globin genotypes. Using LASSO regression, we constructed a nomogram based on four routine complete‐blood‐count parameters (RBC ...
Wen‐jie Yu, Feng‐qi Zhang, Jia‐feng Niu, Rui Ma, Yin‐ting Ma, Guang‐ping Li, Yan Long   +6 more
wiley   +1 more source

Diagnose Mutations Causes Î’-Thalassemia: Biomining Method Using an Optimal Neural Learning Algorithm

International Journal of Engineering and Technology, 2019
The problems in genome and proteome classification of mutations causing a thalassemia are synthesis, e.g. which thalassemia's database will choose? and then the technique that used in biomining to classify mutations causing thalassemia who can say is effective/optimal.
openaire   +1 more source

Diagnosis of α-thalassemia using droplet digital PCR [PDF]

, 2019
Most α-thalassemia occurs due to a large deletion in the α-globin gene. Common α-thalassemia with known mutations, such as Southeast Asian (SEA) type is readily diagnosed by Gap-PCR.
Mori, Kentaro, 山﨑, 隆弘, Ohto, Fukumi, Kimoto, Masafumi, Amao, Yuki, Hattori, Yukio, Mella, Ferania, 末廣, 寛, 山城, 安啓, Ogata, Shizuka   +9 more
core  

Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia

, 2019
This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia.
Camylla Vilas Boas Figueiredo (6954548), Valma Maria Lopes Nascimento (6954566), Valma Maria Lopes Nascimento, Magda Oliveira Seixas Carvalho (6954563), Marilda Souza Goncalves, Rocha, Larissa Carneiro, Magda Oliveira Seixas Carvalho, Adorno, Elisângela Vitória, Larissa Carneiro Rocha, Fiuza, Luciana Magalhães, Caroline Conceição da Guarda, Nascimento, Valma Maria Lopes, Carvalho, Suellen Pinheiro, Carvalho, Magda Oliveira Seixas, Camylla Vilas Boas Figueiredo, Sètondji Cocou Modeste Alexandre Yahouédéhou, Elisângela Vitória Adorno (6954572), Rayra Pereira Santiago (6954551), Uche Samuel Ndidi, Rodrigo Mota Oliveira, Guarda, Caroline Conceição da, Rayra Pereira Santiago, Santiago, Rayra Pereira, Rodrigo Mota Oliveira (6954560), Suellen Pinheiro Carvalho, Elisângela Vitória Adorno, Oliveira, Rodrigo Mota, Larissa Carneiro Rocha (6954569), Luciana Magalhães Fiuza (6954557), Uche Samuel Ndidi (665553), Ndidi, Uche Samuel, Suellen Pinheiro Carvalho (6954554), Goncalves, Marilda Souza, Luciana Magalhães Fiuza, Figueiredo, Camylla Vilas Boas, Isa Menezes Lyra (4407835), Marilda Souza Goncalves (6954575), Lyra, Isa Menezes, Isa Menezes Lyra, Caroline Conceição da Guarda (6954545), Yahouédéhou, Sètondji Cocou Modeste Alexandre, Sètondji Cocou Modeste Alexandre Yahouédéhou (6954542)   +41 more
core   +1 more source

Analysis of Common Alpha-Globin Gene Abnormalities and Their Effects as Genetic Modifiers in Thai Children With β-Globin Gene Abnormalities

Anemia
Beta-thalassemia exhibits a broad phenotypic range influenced by the severity of HBB mutation and various genetic modifiers. One of the most essential modifiers is the coinheritance of α-globin gene mutation.
Sethapong Lertsakulbunlue, Boonchai Boonyawat, Chanchai Traivaree, Apichat Photia   +3 more
doaj   +1 more source

Screening results and analysis on genotype of thalassemia in 108 140 anemia patients in Chongqing

Di-san junyi daxue xuebao, 2020
Objective To investigate the genotypes and distribution characteristics of thalassemia in Chongqing. Methods A total of 108 140 peripheral blood samples were harvested from 36 districts and counties in Chongqing during January 2018 and November 2019 ...
YANG Yuan, ZHU Lidan, ZHANG Ying, LIU Shengyan, CHEN Yongping   +4 more
doaj   +1 more source