Results 61 to 70 of about 965,280 (210)

Cellular and biochemical heterogeneity contributes to the phenotypic diversity of transfusion-dependent β-thalassemia

Blood Advances
Abstract Transfusion-dependent thalassemia (TDT) is a type of protein aggregation disease. Its clinical heterogeneity imposes challenges in effective management. Red blood cell (RBC) variables may be clinically relevant as mechanistic parts or tellers of TDT pathophysiology.
Konstantina Theocharaki, Alkmini T. Anastasiadi, Sophia Delicou, Vassilis L. Tzounakas, Ioanna Barla, Stella Rouvela, Evgenia Kazolia, Georgia Tzafa, George Mpekoulis, Theodore Gousdovas, Efthymia Pavlou, Ioannis V. Kostopoulos, Athanassios D. Velentzas, Nikolaos Simantiris, Aikaterini Xydaki, Niki Vassilaki, Ersi Voskaridou, Ioanna-Katerina Aggeli, Efrosyni Nomikou, Ourania Tsitsilonis, Efstathia Papageorgiou, Nikolaos Thomaidis, Evangelos Gikas, Marianna Politou, Veroniki Komninaka, Marianna H. Antonelou   +25 more
openaire   +3 more sources

Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia

, 2019
This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia.
Camylla Vilas Boas Figueiredo (6954548), Valma Maria Lopes Nascimento (6954566), Valma Maria Lopes Nascimento, Magda Oliveira Seixas Carvalho (6954563), Marilda Souza Goncalves, Rocha, Larissa Carneiro, Magda Oliveira Seixas Carvalho, Adorno, Elisângela Vitória, Larissa Carneiro Rocha, Fiuza, Luciana Magalhães, Caroline Conceição da Guarda, Nascimento, Valma Maria Lopes, Carvalho, Suellen Pinheiro, Carvalho, Magda Oliveira Seixas, Camylla Vilas Boas Figueiredo, Sètondji Cocou Modeste Alexandre Yahouédéhou, Elisângela Vitória Adorno (6954572), Rayra Pereira Santiago (6954551), Uche Samuel Ndidi, Rodrigo Mota Oliveira, Guarda, Caroline Conceição da, Rayra Pereira Santiago, Santiago, Rayra Pereira, Rodrigo Mota Oliveira (6954560), Suellen Pinheiro Carvalho, Elisângela Vitória Adorno, Oliveira, Rodrigo Mota, Larissa Carneiro Rocha (6954569), Luciana Magalhães Fiuza (6954557), Uche Samuel Ndidi (665553), Ndidi, Uche Samuel, Suellen Pinheiro Carvalho (6954554), Goncalves, Marilda Souza, Luciana Magalhães Fiuza, Figueiredo, Camylla Vilas Boas, Isa Menezes Lyra (4407835), Marilda Souza Goncalves (6954575), Lyra, Isa Menezes, Isa Menezes Lyra, Caroline Conceição da Guarda (6954545), Yahouédéhou, Sètondji Cocou Modeste Alexandre, Sètondji Cocou Modeste Alexandre Yahouédéhou (6954542)   +41 more
core   +1 more source

α-Thalassemia impairs the cytoadherence of Plasmodium falciparum-infected erythrocytes. [PDF]

, 2012
α-Thalassemia results from decreased production of α-globin chains that make up part of hemoglobin tetramers (Hb; α(2)β(2)) and affects up to 50% of individuals in some regions of sub-Saharan Africa.
Jeffrey R Keefer, Seidina A S Diakite, Diakite Mahamadou, Lopera-Mesa Tatiana M., Chanaki Amaratunga, Keefer Jeffrey R., Amaratunga Chanaki, Arie Takayuki, Doumbia Saibou, Tatiana M Lopera-Mesa, Mahamadou Diakite, Michael A Krause, Rick M Fairhurst, Diakite Seidina A. S., Takayuki Arie, Karim Traore, Saibou Doumbia, Drissa Konate, Krause Michael A., Fairhurst Rick M., Traore Karim, Konate Drissa   +21 more
core   +1 more source

Deletional a-thalassemia 1 gene detection and hematological analysis in carrier with β-thalassemia

Journal of Associated Medical Sciences, 2012
There are high prevalence of β-thalassemia and α-thalassemia in the upper Northern Thailand. Thus, the interaction between β-thalassemia and α-thalassemia can be occurred.
Sitthichai Panyasai
doaj  

Alpha-Thalassemia: Diversity of Clinical Phenotypes and Update on the Treatment

Thalassemia Reports, 2022
One of the more common single-gene disorders worldwide is α-thalassemia, carriers of which are found at variable frequencies (>1%) across all tropical and subtropical countries.
Duantida Songdej, Suthat Fucharoen
doaj   +1 more source

Development and Validation of a Nomogram Based on Red Blood Cell and Reticulocyte Parameters for Differentiating Thalassemia Trait From Iron Deficiency Anemia

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia trait (TT) and iron deficiency anemia (IDA) are the primary causes of microcytic hypochromic anemia with overlapping hematological features, making their differential diagnosis challenging, so this study developed and validated a nomogram integrating red blood cell (RBC) count, mean corpuscular volume (MCV), reticulocyte percentage (RET ...
Yong Chen, Yazhen Mao, Jie Liu, Yice Lin, Dandan Chen   +4 more
wiley   +1 more source

Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells [PDF]

, 2023
Alpha-thalassemia is an autosomal recessive disease with increasing worldwide prevalence. The molecular basis is due to mutation or deletion of one or more duplicated α-globin genes, and disease severity is directly related to the number of allelic ...
Yin, Han, Conklin, Bruce R, Chu, Simon N, Jia, Kun, Cromer, M Kyle, Wienert, Beeke, Hampton, Jessica P, Homma, Shota, McCreary, Travis, Gardner, James M, Soupene, Eric, MacKenzie, Tippi C, Porteus, Matthew H, Sharma, Devesh   +13 more
core   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

α-Thalassemia, mental retardation, and myelodysplastic syndrome.

, 2012
This article describes three rare syndromes in which the presence of α-thalassemia provided an important clue to the molecular basis of the underlying condition.
Gibbons, Richard, Gibbons, RJ
core   +1 more source

Diagnose Mutations Causes Î’-Thalassemia: Biomining Method Using an Optimal Neural Learning Algorithm

International Journal of Engineering and Technology, 2019
The problems in genome and proteome classification of mutations causing a thalassemia are synthesis, e.g. which thalassemia's database will choose? and then the technique that used in biomining to classify mutations causing thalassemia who can say is effective/optimal.
openaire   +1 more source