Results 141 to 150 of about 3,503,326 (315)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Gene cloning and expression of taro α-galactosidase
, 2010 碩士α-半乳糖水解酶（α-galactosidase）是一種可以將末端半乳糖水解的酵素，在各種生物體中都存在，並且擁有許多不同的生物功能，例如在植物中α-半乳糖水解酶參與醣類的代謝和運輸（source to sink transport）。在應用方面，α-半乳糖水解酶可以使B型紅血球表面抗原上的半乳糖水解而變成O型紅血球，因此藉由基因工程的方法取得基因並利用 Pichia pastoris 的蛋白質表現系統來產生大量的芋頭 α-半乳糖水解酶以進行血行轉換的測試和應用 ...
李皇毅; Lee, Houng-yi
core
ÎΟΥΣ, ÎΟΗΣΒΣ, ÎΟΕΒΠand derivatives, in Plato's Philosophy
Revista ArchaiThe article shows that several studies on the meaning of νοῦς, νόησις, νοεῖν, and derivatives in pre-Platonic literature, especially in Homer, but also in some pre-Socratic thinkers, have concluded that these terms are never used in strictly abstract situations, but, on the contrary, always appear linked to emotions connected to concrete events.
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á½¥ÏƒÏ€ÎµÏ á¼´Ï‡Î½ÎµÏƒÎ¹ τοῖς ὀνόμασι. Plutarch’s Cratylus
Ploutarchos, 2023 The article traces the presence of Plato’s Cratylus" in the works of Plutarch, with a particular focus on its refunctionalization within the Plutarchian discursive context. Building on several scholarly contributions on this subject, the article highlights Plutarch’s exegetical sophistication, demonstrating his ability to selectively appropriate and ...
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Revista Filosófica de Coimbra, 2019 This paper focuses on Antigone’s first stasimon and tries to work out its meaning. The key question to be answered is: what image of man underlies the famous choral ode? This key question can be divided into several sub-questions:1) In what sense is man said to be δεινόν and indeed the most δεινόν thing of all?2) What is the connection ...
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source