Results 161 to 170 of about 7,298,112 (344)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Tumor necrosis factor-α (TNF-α) in canine osteoarthritis: Immunolocalization of TNF-α, stromelysin and TNF receptors in canine osteoarthritic cartilage

, 1996
J. R. Kammermann, Steven A. Kincaid, Paul F. Rumph, Debra K. Baird, Denise M. Visco   +4 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

FROM H i TO STARS: H I DEPLETION IN STARBURSTS AND STAR-FORMING GALAXIES IN THE ALFALFA HαSURVEY [PDF]

, 2015
A. E. Jaskot, M. S. Oey, J. J. Salzer, A. Van Sistine, E. F. Bell, M. P. Haynes   +5 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Z α ₁ -Antitrypsin Confers a Proinflammatory Phenotype That Contributes to Chronic Obstructive Pulmonary Disease

, 2014
Samuel Alam, Zhenjun Li, Carl Atkinson, Danny Jonigk, Sabina Janciauskiene, Ravi Mahadeva   +5 more
openalex   +1 more source

Calcium/calmodulin‐dependent kinase II activity is required for maintaining learning‐induced enhancement of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor‐mediated synaptic excitation [PDF]

, 2015
Sourav Ghosh, Iris Reuveni, Edi Barkai, Raphael Lamprecht   +3 more
openalex   +1 more source

Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals

, 2021
Tomohiro Suzuki, Mayuko Hayashi, Tetsuro Komatsu, Akiko Tanioka, Masahiro Nagasawa, Kyoko Tanimura-Inagaki, Mohammad Sharifur Rahman, Shinnosuke Masuda, Kosuke Yusa, Juro Sakai, Hiroshi Shibata, Takeshi Inagaki   +11 more
openalex   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Human Peripheral CD4+ Vδ1+ γδT Cells Can Develop into αβT Cells [PDF]

Frontiers in Immunology, 2014
Hendrik Ziegler, Christian Welker, Marco Sterk, Jan Haarer, Hans-Georg Rammensee, Rupert Handgretinger, Karin Schilbach   +6 more
openaire   +1 more source