Results 11 to 20 of about 6,634 (135)

The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site [PDF]

Toxins, 2021
α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR.
Alican Gülsevin, Roger L Papke, Clare Stokes   +2 more
exaly   +4 more sources

Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier [PDF]

Frontiers in Immunology, 2021
Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) is critical for the pathogenesis of Escherichia coli (E. coli) K1 meningitis, a severe central nervous system infection of the neonates. However, little is known about how E.
Xiaolong He, Xiaolong He, Lei Wang, Liqun Liu, Liqun Liu, Jie Gao, Jie Gao, Beiguo Long, Feng Chi, Tongtong Hu, Yu Wan, Zelong Gong, Li Li, Li Li, Peilin Zhen, Tiesong Zhang, Hong Cao, Sheng-He Huang, Sheng-He Huang, Sheng-He Huang   +19 more
doaj   +2 more sources

Good Manufacturing Practice Validation and Radiation Dosimetry for the Clinical Application of a Novel α7-nAChR Radioligand: [¹¹C]KIn83. [PDF]

Molecules
Nicotinic acetylcholine receptor (α7-nAChR) plays a crucial role in cognitive functions like memory and attention. Positron emission tomography (PET) imaging of α7-nAChR is gaining attraction for understanding and monitoring central nervous system disorders, such as Alzheimer’s disease, Parkinson’s disease, and schizophrenia. We developed [11C]KIn83, a
Jia Z, Bolin M, Morén AF, Datta P, Asem H, Ågren H, Långström B, Nordberg A, Halldin C, Nag S.   +9 more
europepmc   +5 more sources

AAV.PHP.eB-based strategies for precise modulation of α7 nicotinic acetylcholine receptor in neurons and astrocytes in the adult mouse brain [PDF]

Scientific Reports
Precise control of the α7 nicotinic acetylcholine receptor (α7-nAChR) in specific brain cell types is crucial for understanding its role in neural circuit function and disease.
Giulia Puliatti, Pietro Renna, Martina Battistoni, Roberto Piacentini, Cristian Ripoli, Claudio Grassi   +5 more
doaj   +2 more sources

Inflammation Regulation via an Agonist and Antagonists of α7 Nicotinic Acetylcholine Receptors in RAW264.7 Macrophages

Marine Drugs, 2022
The α7 nicotinic acetylcholine receptor (nAChR) is widely distributed in the central and peripheral nervous systems and is closely related to a variety of nervous system diseases and inflammatory responses.
Yao Tan, Zhaoli Chu, Hongyu Shan, Dongting Zhangsun, Xiaopeng Zhu, Sulan Luo   +5 more
doaj   +1 more source

Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription

Cell Insight, 2022
Alpha7 nicotinic acetylcholine receptor (α7 nAChR), a hub of the cholinergic anti-inflammatory pathway (CAP), is required for the treatment of inflammatory diseases.
Jing Wen, Caiqi Zhao, Jie Chen, Shuting Song, Zhekai Lin, Shitao Xie, Huaxin Qi, Jianhua Wang, Xiao Su   +8 more
doaj   +1 more source

Synthesis and Evaluation of Compound Targeting α7 and β2 Subunits in Nicotinic Acetylcholinergic Receptor

Molecules, 2023
Nicotinic acetylcholine receptors (nAChRs) are involved in various central nervous system functions and have also been implicated in several neurodegenerative disorders.
Karanveer Singh, Allyson Ngo, Oshini V. Keerthisinghe, Krystal K. Patel, Christopher Liang, Jogeshwar Mukherjee   +5 more
doaj   +1 more source

Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats. [PDF]

PLoS ONE, 2011
The α7 nicotinic acetylcholine receptor (nAChR) is a potential target for the treatment of cognitive deficits in patients with schizophrenia, ADHD and Alzheimer's disease.
Morten S Thomsen, Mona El-Sayed, Jens D Mikkelsen   +2 more
doaj   +1 more source

Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. [PDF]

PLoS ONE, 2016
Cigarette smoking is the major risk factor for non-small cell lung cancer (NSCLC), which accounts for 80% of all lung cancers. Nicotine, the addictive component of tobacco smoke, can induce proliferation, migration, invasion, epithelial-mesenchymal ...
Courtney Schaal, Srikumar Chellappan
doaj   +1 more source

Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

Journal of Neuroinflammation, 2017
Background α7 nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system and are reported to have neuroprotective properties.
Hiral Patel, Jessica McIntire, Sarah Ryan, Anthone Dunah, Ralph Loring   +4 more
doaj   +1 more source