Results 11 to 20 of about 18,354 (167)
Acta Pharmaceutica Sinica B, 2017 The alpha-7 nicotinic acetylcholine receptor (α7 nAChR), consisting of homomeric α7 subunits, is a ligand-gated Ca2+-permeable ion channel implicated in cognition and neuropsychiatric disorders.
Taoyi Yang +3 more
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Enriched environment alleviates post-stroke cognitive impairment through enhancing α7-nAChR expression in rats [PDF]
Arquivos de Neuro-Psiquiatria, 2020 Background: Enriched environment (EE) is a simple and effective intervention to improve cognitive function in post-stroke cognitive impairment (PSCI), partly due to the rebalancing of the cholinergic signaling pathway in the hippocampus.
Mei YUAN +3 more
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Sulfonium Ligands of the α7 nAChR. [PDF]
Molecules, 2021 The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor are ...
Horenstein NA, Stokes C, Papke RL.
europepmc +2 more sources
Acta Pharmaceutica Sinica B, 2020 Acetylcholine (ACh) regulates inflammation via α7 nicotinic acetylcholine receptor (α7 nAChR). Acetylcholinesterase (AChE), an enzyme hydrolyzing ACh, is expressed in immune cells suggesting non-classical function in inflammatory responses.
Etta Y.L. Liu +8 more
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In silico studies of ASEM analogues targeting α7-nAChR and experimental verification. [PDF]
RSC Adv, 2021 The α7 nicotinic acetylcholine receptor (α7-nAChR) is implicated in a variety of neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease (AD) and schizophrenia.
Zhou Y +7 more
europepmc +2 more sources
Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes. [PDF]
ACS Chem NeurosciPDZ domains are modular domains that conventionally bind to C terminal or internal motifs of target proteins to control cellular functions through the regulation of protein complex assemblies.
Bondarenko V +4 more
europepmc +2 more sources
The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site [PDF]
, 2023 α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR.
Stokes, Clare +6 more
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Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. [PDF]
PLoS ONE, 2016 Cigarette smoking is the major risk factor for non-small cell lung cancer (NSCLC), which accounts for 80% of all lung cancers. Nicotine, the addictive component of tobacco smoke, can induce proliferation, migration, invasion, epithelial-mesenchymal ...
Courtney Schaal, Srikumar Chellappan
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, 2021 Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) is critical for the pathogenesis of Escherichia coli (E. coli) K1 meningitis, a severe central nervous system infection of the neonates. However, little is known about how E.
Liqun Liu (316613) +13 more
core +1 more source
, 2021 Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) is critical for the pathogenesis of Escherichia coli (E. coli) K1 meningitis, a severe central nervous system infection of the neonates. However, little is known about how E.
Liqun Liu (316613) +13 more
core +1 more source