Results 21 to 30 of about 18,354 (167)

Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

Journal of Neuroinflammation, 2017
Background α7 nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system and are reported to have neuroprotective properties.
Hiral Patel, Jessica McIntire, Sarah Ryan, Anthone Dunah, Ralph Loring   +4 more
doaj   +1 more source

A G protein‐coupled α7 nicotinic receptor regulates signaling and TNF‐α release in microglia

FEBS Open Bio, 2017
Acetylcholine activation of α7 nicotinic acetylcholine receptors (α7 nAChRs) in microglia attenuates neuroinflammation and regulates TNF‐α release. We used lipopolysaccharide to model inflammation in the microglial cell line EOC20 and examined signaling ...
Justin R. King, Trudy C. Gillevet, Nadine Kabbani   +2 more
doaj   +1 more source

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse

Biomolecules, 2020
Objective: Type 2 diabetes (T2D) occurs by deterioration in pancreatic β-cell function and/or progressive loss of pancreatic β-cell mass under the context of insulin resistance.
Blandine Gausserès, Junjun Liu, Ewout Foppen, Cécile Tourrel-Cuzin, Ana Rodriguez Sanchez-Archidona, Etienne Delangre, Céline Cruciani-Guglielmacci, Stéphanie Pons, Uwe Maskos, Bernard Thorens, Christophe Magnan, Jamileh Movassat, Kamel Maouche   +12 more
doaj   +1 more source

The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice

Biomedicines, 2023
Nicotine, an abundant molecule in tobacco, has immunomodulatory effects on inflammatory diseases, primarily due to the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR).
Young-Eun Kim, Jae-Hyun Lee, Eun-Ju Lee, Do Hoon Kim, Mi Ryeong Jeong, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Jeehee Youn, Eun-Ju Chang, Yong-Gil Kim   +10 more
doaj   +1 more source

α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension

JCI Insight, 2021
Right ventricular (RV) fibrosis is a key feature of maladaptive RV hypertrophy and dysfunction and is associated with poor outcomes in pulmonary hypertension (PH).
Alexander Vang, Denielli da Silva Gonçalves Bos, Ana Fernandez-Nicolas, Peng Zhang, Alan R. Morrison, Thomas J. Mancini, Richard T. Clements, Iuliia Polina, Michael W. Cypress, Bong Sook Jhun, Edward Hawrot, Ulrike Mende, Jin O-Uchi, Gaurav Choudhary   +13 more
doaj   +1 more source

Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals

Molecules, 2021
We previously reported that lipopolysaccharide (LPS) challenge caused microglial-mediated neuroinflammation and sickness behavior that was amplified in aged mice.
Elisa Navarro, Diana M. Norden, Paige J. Trojanowski, Jonathan P. Godbout, Manuela G. López   +4 more
doaj   +1 more source

Recombinant Newcastle disease virus rL-RVG enhances the apoptosis and inhibits the migration of A549 lung adenocarcinoma cells via regulating alpha 7 nicotinic acetylcholine receptors in vitro

Virology Journal, 2017
Background The aim of this study were to investigate the possible pro-apoptotic mechanisms of the recombinant Newcastle disease virus (NDV) strain rL-RVG, which expresses the rabies virus glycoprotein, in A549 lung adenocarcinoma cells via the regulation
Yulan Yan, Chunxiang Su, Min Hang, Hua Huang, Yinghai Zhao, Xiaomei Shao, Xuefeng Bu   +6 more
doaj   +1 more source

Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo

Frontiers in Cell and Developmental Biology, 2023
α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative modulator of α7-nAChR produced by epithelial cells.
O. V. Shlepova, O. V. Shlepova, M. A. Shulepko, V. O. Shipunova, V. O. Shipunova, M. L. Bychkov, I. D. Kukushkin, I. D. Kukushkin, I. A. Chulina, V. N. Azev, E. I. Shramova, V. A. Kazakov, A. M. Ismailova, Y. A. Palikova, V. A. Palikov, E. A. Kalabina, E. A. Shaykhutdinova, G. A. Slashcheva, E. A. Tukhovskaya, I. A. Dyachenko, A. N. Murashev, S. M. Deyev, S. M. Deyev, S. M. Deyev, M. P. Kirpichnikov, M. P. Kirpichnikov, Z. O. Shenkarev, Z. O. Shenkarev, Z. O. Shenkarev, E. N. Lyukmanova, E. N. Lyukmanova, E. N. Lyukmanova   +31 more
doaj   +1 more source

Nicotine Elevated Intracellular Ca2+ in Rat Airway Smooth Muscle Cells via Activating and Up-Regulating α7-Nicotinic Acetylcholine Receptor

Cellular Physiology and Biochemistry, 2014
Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling with airway smooth muscle (ASM) hypertrophy and hyperplasia.
Yongliang Jiang, Aiguo Dai, Yumin Zhou, Gongyong Peng, Guoping Hu, Bing Li, James S.K. Sham, Pixin Ran   +7 more
doaj   +1 more source

Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. [PDF]

PLoS ONE, 2011
Alpha7 nicotinic acetylcholine receptor (nAChR), an essential regulator of inflammation, is abundantly expressed in hippocampal neurons, which are vulnerable to bacterial meningitis.
Feng Chi, Lin Wang, Xueye Zheng, Chun-Hua Wu, Ambrose Jong, Michael A Sheard, Wei Shi, Sheng-He Huang   +7 more
doaj   +1 more source