Results 31 to 40 of about 6,634 (135)

Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. [PDF]

PLoS ONE, 2011
Alpha7 nicotinic acetylcholine receptor (nAChR), an essential regulator of inflammation, is abundantly expressed in hippocampal neurons, which are vulnerable to bacterial meningitis.
Feng Chi, Lin Wang, Xueye Zheng, Chun-Hua Wu, Ambrose Jong, Michael A Sheard, Wei Shi, Sheng-He Huang   +7 more
doaj   +1 more source

Targeting α7 nicotinic acetylcholine receptors for chronic pain

Frontiers in Molecular Neuroscience, 2022
Despite rapid advances in the field of chronic pain, it remains extremely challenging in the clinic. Pain treatment strategies have not improved for decades as opioids remain the main prescribed drugs for chronic pain management.
Ya-Qun Zhou, Dai-Qiang Liu, Cheng Liu, Ai-Jun Xu, Yu-Ke Tian, Wei Mei, Xue-Bi Tian   +6 more
doaj   +1 more source

The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper–zinc superoxide dismutase 1-mediated toxicity

Scientific Reports, 2020
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective and progressive loss of motor neurons. Although many drugs have entered clinical trials, few have shown effectiveness in the treatment of ALS.
Taisei Ito, Masatoshi Inden, Tomoyuki Ueda, Yuta Asaka, Hisaka Kurita, Isao Hozumi   +5 more
doaj   +1 more source

Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression

Biomolecules, 2020
Immune response during sepsis is characterized by hyper-inflammation followed by immunosuppression. The crucial role of macrophages is well-known for both septic stages, since they are involved in immune homeostasis and inflammation, their dysfunction ...
Andrei E. Siniavin, Maria A. Streltsova, Denis S. Kudryavtsev, Irina V. Shelukhina, Yuri N. Utkin, Victor I. Tsetlin   +5 more
doaj   +1 more source

Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study

Molecules, 2021
Several antidepressants inhibit nicotinic acetylcholine receptors (nAChRs) in a non-competitive and voltage-dependent fashion. Here, we asked whether antidepressants with a different structure and pharmacological profile modulate the rat α7 nAChR through
Yorley Duarte, Maximiliano Rojas, Jonathan Canan, Edwin G. Pérez, Fernando González-Nilo, Jesús García-Colunga   +5 more
doaj   +1 more source

Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. [PDF]

PLoS ONE, 2013
Presynaptic nicotinic acetylcholine receptors (nAChRs) have long been implicated in the modulation of CNS circuits. We previously reported that brief exposure to low concentrations of nicotine induced sustained potentiation of glutamatergic transmission ...
Chongbo Zhong, David A Talmage, Lorna W Role   +2 more
doaj   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone.

PLoS ONE, 2018
The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that plays an important role in cellular calcium signaling contributing to synaptic development and plasticity, and is a key drug target for the treatment of neurodegenerative ...
Justin R King, Nadine Kabbani
doaj   +1 more source

Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: Implications for neuropsychiatric diseases

Neurobiology of Disease, 2014
Microdeletion of the human CHRNA7 gene (α7 nicotinic acetylcholine receptor, nAChR) as well as dysfunction in N-methyl-d-aspartate receptors (NMDARs) have been associated with cortical dysfunction in a broad spectrum of neurodevelopmental and ...
Hong Lin, Fu-Chun Hsu, Bailey H. Baumann, Douglas A. Coulter, David R. Lynch   +4 more
doaj   +1 more source

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

MedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato   +5 more
wiley   +1 more source