Results 31 to 40 of about 18,354 (167)
Targeting α7 nicotinic acetylcholine receptors for chronic pain
Frontiers in Molecular Neuroscience, 2022 Despite rapid advances in the field of chronic pain, it remains extremely challenging in the clinic. Pain treatment strategies have not improved for decades as opioids remain the main prescribed drugs for chronic pain management.
Ya-Qun Zhou +6 more
doaj +1 more source
Confirmation of α7 nAChR surface expression on mouse macrophages.
, 2019 (A) PCR analysis showing a band of 264 bp size confirming the presence of α7 nAChR mRNA in macrophages isolated from WT but not α7 nAChR knockout mice. The 100 base pair ladder was from New England Biolabs. No RT: No reverse transcriptase control.
Brijesh K. Garg (6556034) +1 more
core +1 more source
Scientific Reports, 2020 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective and progressive loss of motor neurons. Although many drugs have entered clinical trials, few have shown effectiveness in the treatment of ALS.
Taisei Ito +5 more
doaj +1 more source
Biomolecules, 2020 Immune response during sepsis is characterized by hyper-inflammation followed by immunosuppression. The crucial role of macrophages is well-known for both septic stages, since they are involved in immune homeostasis and inflammation, their dysfunction ...
Andrei E. Siniavin +5 more
doaj +1 more source
Molecules, 2021 Several antidepressants inhibit nicotinic acetylcholine receptors (nAChRs) in a non-competitive and voltage-dependent fashion. Here, we asked whether antidepressants with a different structure and pharmacological profile modulate the rat α7 nAChR through
Yorley Duarte +5 more
doaj +1 more source
, 2014 The neuronal nicotinic alpha7-acetylcholine receptor (α7-nAChR) is a promising and attractive drug target for improving cognitive deficits in neuropsychiatric and neurological disorders such as Alzheimer's disease (AD).
Frustaci, Alessandra, Cesario, Alfredo
core +1 more source
Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. [PDF]
PLoS ONE, 2013 Presynaptic nicotinic acetylcholine receptors (nAChRs) have long been implicated in the modulation of CNS circuits. We previously reported that brief exposure to low concentrations of nicotine induced sustained potentiation of glutamatergic transmission ...
Chongbo Zhong +2 more
doaj +1 more source
Development of a Nicotinic Acetylcholine Receptor nAChR α7 Binding Activity Prediction Model [PDF]
, 2020 Despite the well-known adverse health effects associated with tobacco use, addiction to nicotine found in tobacco products causes difficulty in quitting among users. Nicotinic acetylcholine receptors (nAChRs) are the physiological targets of nicotine and
Wenjing Guo (676944) +11 more
core +2 more sources
, 2018 α7-nAChR is a nicotinic acetylcholine receptor [specifically expressed on hepatic stellate cells (HSCs), Kupffer cells, and cholangiocytes] that regulates inflammation and apoptosis in the liver.
Nan Wu +14 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li +9 more
wiley +1 more source