Results 91 to 100 of about 1,291,117 (154)

Identifying of important sites of the conducting pore of nicotinic acetycholine receptor through two-electrode voltage-clamp [PDF]

Jichu yixue yu linchuang, 2021
Objective To detect the main amino acid sites in the ion-conducting pore of the human α7 nicotinic acetycholine receptor(α7nAChR) by two-electrode voltage-clamp.
XUE Fen-qin, LI Hua, LIU Li-na, XU Qing, XUE Bing, WEI Hua
doaj  

Nicotinic Mitigation of Neuroinflammation and Oxidative Stress After Chronic Sleep Deprivation

Frontiers in Immunology, 2019
Sleep deprivation negatively influences all aspects of health. Oxidative stress and inflammatory responses induced by sleep deprivation participate in its adverse effects but the regulatory mechanisms to counteract them remain poorly understood.
Rong Xue, Yahui Wan, Xiaoqian Sun, Xuan Zhang, Wei Gao, Wei Wu   +5 more
doaj   +1 more source

Migration of gastric cancer is suppressed by recombinant Newcastle disease virus (rL-RVG) via regulating α7-nicotinic acetylcholine receptors/ERK- EMT

BMC Cancer, 2019
Background Nicotinic acetylcholine receptors (nAChRs) have been reported to be overexpressed in malignancies in humans and is associated with tumorigenesis and cell migration. In previous studies of gastric cancer, alpha7 nicotinic acetylcholine receptor
Xuefeng Bu, Anwei Zhang, Zhengwei Chen, Xuanfeng Zhang, Riting Zhang, Chaoyun Yin, Jie Zhang, Yao Zhang, Yulan Yan   +8 more
doaj   +1 more source

Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors

Beilstein Journal of Organic Chemistry, 2007
BackgroundThe 5,8-disubstituted indolizidines constitute the largest class of poison-frog alkaloids. Some alkaloids have been shown to act as noncompetitive blockers at nicotinic acetylcholine receptors but the proposed structures and the biological ...
Soushi Kobayashi, Naoki Toyooka, Dejun Zhou, Hiroshi Tsuneki, Tsutomu Wada, Toshiyasu Sasaoka, Hideki Sakai, Hideo Nemoto, H. Martin Garraffo, Thomas F. Spande, John W. Daly   +10 more
doaj   +1 more source

A novel anxiety-associated SNP identified in LYNX2 (LYPD1) is associated with decreased protein binding to nicotinic acetylcholine receptors

Frontiers in Behavioral Neuroscience
IntroductionAnxiety disorders are among the most common mental illnesses in the US. An estimated 31.1% of U.S. adults experience any anxiety disorder at some time in their lives.
Kristin R. Anderson, Wenpeng Cao, Hui Sun Lee, Mark A. Crenshaw, Talulla B. Palumbo, Ethan Fisher-Perez, Amanda DeGraaf, Peter Rogu, Maria A. Beatty, Gabrielle M. Gracias, Gabrielle M. Gracias, Avani V. Pisapati, Katie Hoffman, Krystle J. McLaughlin, Almut Hupbach, Wonpil Im, Wonpil Im, X. Frank Zhang, Julie M. Miwa   +18 more
doaj   +1 more source

Substituted 2‑Aminopyrimidines Selective for α7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins

, 2017
Through studies with ligand binding to the acetylcholine binding protein (AChBP), we previously identified a series of 4,6-substituted 2-aminopyrimidines that associate with this soluble surrogate of the nicotinic acetylcholine receptor (nAChR) in a ...
Gisela Andrea Camacho Hernandez (3805327), Larissa Kohs (3805336), Jose Manuel Cornejo-Bravo (3805330), Palmer Taylor (40801), M. G. Finn (1332078), Larissa Bendiks (3805333), Michal Harel (162894), Katarzyna Kaczanowska (1507603)   +7 more
core   +1 more source

Screening, Synthesis and Structural Characterization of a Novel Bicyclic Peptide Inhibiting α7 Nicotinic Acetylcholine Receptor

Peptides targeting the α7 nicotinic acetylcholine receptor (α7-nAChR) represent promising candidates for therapeutic and chemical probe development, though currently limited to naturally occurring products and their derivatives.
Xichu Yang, Xiuxiu Cao, Changlin Tian, Demeng Sun, Haopeng Chen, Kele Cui   +5 more
core   +1 more source

Localization of α7 Nicotinic Acetylcholine Receptor mRNA and Protein Within the Cholinergic Anti-Inflammatory Pathway

, 2014
Electrical stimulation of the vagus nerve attenuates tumor necrosis factor (TNF) synthesis by macrophages and reduces the systemic inflammatory response.
Bond, C. E., Hoover, D. B., Downs, A. M.
core   +1 more source

P86 | THE EFFECTS OF NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITION ON THE EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR IN THE OLFACTORY BULB ORGANOTYPIC SLICE CULTURES

European Journal of Histochemistry
Olfactory bulb (OB) exhibits high levels of nicotinic acetylcholine receptor (nAChR) expression and receive strong cholinergic input from the basal forebrain. Acetylcholine is important modulator in olfactory related memory.
doaj   +1 more source

Pharmacological characterization of the novel and selective α7 nicotinic acetylcholine receptor positive allosteric modulator BNC375

, 2020
Treatments for cognitive deficits associated with CNS disorders such as Alzheimer's disease (AD) and schizophrenia remain significant unmet medical needs that incur substantial pressure on the healthcare system.
Zhou, Xiaoping, Thomson, Fiona, O’Connor, Susan M., Grishin, Anton A., Miller, Corin O., Coles, Carolyn J., Vardigan, Joshua D., Gakhar, Vanita, Lange, Henry, Belden, Michelle, Uslaner, Jason M., Duffy, Joseph L., Harvey, Andrew J., Wang, Xiaohai, Warren, Lee, Daley, Christopher, Bell, Ian M., Pearson, Michelle   +17 more
core   +1 more source