Results 81 to 90 of about 1,291,117 (154)

Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

, 2016
The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR)
Balle, Thomas, Halliday, Jill, Absalom, Nathan, Harpsoe, Kaspar, McLeod, Malcolm, Chebib, Mary, Ambrus, Joseph, Kanizaj, Nicholas   +7 more
core   +1 more source

Vagus nerve stimulation alleviates alveolar bone loss and inflammation in ligature-induced periodontitis rat model [PDF]

Journal of Applied Oral Science
Objective Vagus nerve stimulation (VNS) can inhibit inflammation in various diseases by activating the cholinergic anti-inflammatory pathway. However, whether VNS could attenuate periodontitis by activating α7-nicotinic acetylcholine receptor (α7-nAChR)
Honghui XIE, Ping HUANG, Aihong TAN, Zhijian SU, Ying FU   +4 more
doaj   +1 more source

Increased Binding of [18F]Nifene, a PET Imaging Probe for α4β2* Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Parkinson's Disease Brain

Synapse, Volume 80, Issue 5, September 2026.
[18F]Nifene, a PET imaging probe for α4β2* nicotinic acetylcholine receptors, was used to discretely measure changes in hippocampus (HP) and subiculum (SUB) of postmortem Parkinson's disease (PD) cases compared to cognitively normal (CN) cases. Significant increased [18F]nifene binding in PD was observed.
Jogeshwar Mukherjee, Fariha Karim, Allyson Ngo, Christopher Liang, Geidy E. Serrano, Thomas G. Beach   +5 more
wiley   +1 more source

Cloning and Expression of Cockroach α7 Nicotinic Acetylcholine Receptor Subunit

Frontiers in Physiology, 2020
Understanding insect nicotinic acetylcholine receptor (nAChR) subtypes is of major interest because they are the main target of several insecticides.
Alison Cartereau, Emiliane Taillebois, Balaji Selvam, Carine Martin, Jérôme Graton, Jean-Yves Le Questel, Steeve H. Thany   +6 more
doaj   +1 more source

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

British Journal of Pharmacology, Volume 183, Issue 18, Page 5458-5475, September 2026.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle, Lluna Careaga, Stefanie Malan‐Müller, Álvaro del Río‐García, Yaiza Trueba, Leticia Gil de Biedma‐Elduayen, Nuria Morales‐Puerto, Rebeca Vidal, Åsa Wiman, Sophie Erhardt, María Dolores Gutiérrez‐López, Esther O'Shea, María Isabel Colado   +12 more
wiley   +1 more source

Hippocampal α7 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder

, 2011
The α7 nicotinic acetylcholine receptor (nAChR) is involved in cognitive function and synaptic plasticity. Consequently, changes in α7 nAChR function have been implicated in a variety of mental disorders, especially schizophrenia.
Annelies Weyn, Jens D Mikkelsen, Thomsen, Morten Skøtt, Mikkelsen, Jens D, Morten S Thomsen, Weyn, Annelies   +5 more
core   +1 more source

Ultrastructural Distribution of the α7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus [PDF]

, 2001
Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic receptors contribute to these cholinergic effects, in addition to ...
Davies, Heather A., Ruth Fabian-Fine, Emanuele Sher, Errington, Mick L., Fabian Fine, Ruth, Mick L. Errington, Paul Skehel, Skehel, Paul, Sher, Emanuele, Alan Fine, Heather A. Davies, Michael G. Stewart, Stewart, Michael G.   +12 more
core   +1 more source

Curcumin Derivatives as Allosteric Modulator of α7-nAChR: Functional and Molecular Docking Insights

Medical Principles and Practice
Background: Curcumin has emerged as promising candidate for therapeutic modulation of neurodegenerative disorders by acting on α7-nicotinic acetylcholine receptor (α7-nAChR).
Eslam ElNebrisi, Mohammad A. Ghattas, Noor Atatreh, Sonia Hasan, Murat Oz   +4 more
doaj   +1 more source

Topical Donepezil for Cholinergic Modulation in Chronic Wound Repair

Wound Repair and Regeneration, Volume 34, Issue 5, September/October 2026.
ABSTRACT Chronic wounds result from combined defects in vascular perfusion, inflammatory resolution, and epithelial repair. The skin's non‐neuronal cholinergic system (NNCS), formed by keratinocytes, endothelial cells, fibroblasts, and immune cells that synthesise and respond to acetylcholine (ACh), helps coordinate these processes through muscarinic ...
Hui‐Qi Qu, Charlly Kao, Hakon Hakonarson   +2 more
wiley   +1 more source

The α7 nAChR Agonist PNU-282987 Reduces Inflammation and MPTP-Induced Nigral Dopaminergic Cell Loss in Mice

Journal of Parkinson’s Disease, 2013
Background: Parkinson's disease (PD) is associated with neurodegeneration of dopaminergic neurons and an accompanying neuroinflammatory process in the substantia nigra (SN).
Vanessa Stuckenholz, Michael Bacher, Monika Balzer-Geldsetzer, Daniel Alvarez-Fischer, Wolfgang H. Oertel, Richard C. Dodel, Carmen Noelker   +6 more
doaj   +1 more source