Results 51 to 60 of about 14,399 (162)

Dystrophin Stabilizes α3- But Not α7-Containing Nicotinic Acetylcholine Receptor Subtypes at the Postsynaptic Apparatus in the Mouse Superior Cervical Ganglion

Neurobiology of Disease, 2002
The nicotinic acetylcholine receptor (nAChR) subtypes were characterized in the superior cervical ganglion (SCG) of wild-type and dystrophin-lacking mdx mice.
Arianna Del Signore, Cecilia Gotti, M.Egle De Stefano, Milena Moretti, Paola Paggi   +4 more
doaj   +1 more source

Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596. [PDF]

PLoS ONE, 2012
Positive allosteric modulators of highly Ca(2+)-permeable α7 nicotinic acetylcholine receptors, such as PNU-120596, may become useful therapeutic tools supporting neuronal survival and function.
Victor V Uteshev
doaj   +1 more source

TLR2 and TLR4 Modulate Mouse Ileal Motility by the Interaction with Muscarinic and Nicotinic Receptors

Cells, 2022
Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by intestinal dysmotility. Changes in intestinal microbiota (dysbiosis) can lead to alterations in neuro-muscular functions in the gut. Toll-like receptors (TLRs) 2 and 4
Elena Layunta, Raquel Forcén, Laura Grasa   +2 more
doaj   +1 more source

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function [PDF]

, 2015
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery.
Freedman, Robert, Graw, Sharon, Leonard, Sherry, Lester, Henry A., Ross, Randal G., Sinkus, Melissa L.   +5 more
core   +1 more source

A7DB: a relational database for mutational, physiological and pharmacological data related to the α7 nicotinic acetylcholine receptor

BMC Neuroscience, 2005
Background Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most intensively studied nAChR subunits
Sansom Mark SP, Brown Laurence, Jones Andrew K, Pym Luanda, Buckingham Steven D, Sattelle David B, Biggin Philip C   +6 more
doaj   +1 more source

Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs. [PDF]

PLoS ONE, 2013
Functional α7 nicotinic acetylcholine receptors (AChRs) do not assemble efficiently in cells transfected with α7 subunits unless the cells are also transfected with the chaperone protein RIC-3.
Alexander Kuryatov, Jayanta Mukherjee, Jon Lindstrom   +2 more
doaj   +1 more source

Nicotinic acetylcholine receptors modulate osteoclastogenesis [PDF]

, 2016
Background: Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis.
A Bajayo, A Orr-Urtreger, A Yarilina, AJ Ewins, Attila Mócsai, CL Henemyre, David Győri, DE Rothem, Despoina Sykoutri, DK Williams, E Somm, EX Albuquerque, FC Macintosh, Gyula Poór, H Takayanagi, H Tanaka, H Tanaka, I Wessler, J Tam, JA Dani, Josef S. Smolen, K Kawashima, K Kliemann, K Redlich, KJ Tracey, KS Lips, Kurt Redlich, LM Koval, LM Walker, LZ Wu, M Artico, M Asagiri, M En-Nosse, M Kedmi, M Rosas-Ballina, MA Fang, MA Maanen van, MR McClung, MR Picciotto, O Herault, PC Staton, Peter Mandl, Petra Scholze, R Reitstetter, RL Papke, S Hayer, S Yuhara, SB Cohen, Sigismund Huck, Silvia Hayer, SJ Romano, Stephan Blüml, T Koga, T Negishi-Koga, T Sato, Thomas Karonitsch, V Itier, ZQ Wang   +57 more
core   +2 more sources

Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice

Nature Communications
Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and
Quynh-Anh Nguyen, Peter M. Klein, Cheng Xie, Katelyn N. Benthall, Jillian Iafrati, Jesslyn Homidan, Jacob T. Bendor, Barna Dudok, Jordan S. Farrell, Tilo Gschwind, Charlotte L. Porter, Annahita Keravala, G. Steven Dodson, Ivan Soltesz   +13 more
doaj   +1 more source

Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse

Scientific Reports, 2017
In neonatal mice motoneurons excite Renshaw cells by releasing both acetylcholine (ACh) and glutamate. These two neurotransmitters activate two types of nicotinic receptors (nAChRs) (the homomeric α7 receptors and the heteromeric α*ß* receptors) as well
Boris Lamotte d’Incamps, Gardave S. Bhumbra, Joshua D. Foster, Marco Beato, Philippe Ascher   +4 more
doaj   +1 more source

Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. [PDF]

PLoS ONE, 2014
Three recently discovered tentacle muscles are crucial to perform patterned movements of upper tentacles of the terrestrial snail, Helix pomatia. The muscles receive central and peripheral excitatory cholinergic innervation lacking inhibitory innervation.
Tibor Kiss, Nóra Krajcs, Zsolt Pirger, László Hernádi   +3 more
doaj   +1 more source