Results 61 to 70 of about 14,399 (162)

Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers [PDF]

, 2017
Cigarette smoking is associated with increased risk for all histologic types of lung cancer, but why the strength of this association is stronger for squamous cell carcinoma than adenocarcinoma of the lung (SQC-L, ADC-L) is not fully understood ...
Arnalich, Francisco, Atienza, Gema, Bordas, Anna, Castro, Javier de, Cedillo, José Luis, Esteban-Rodríguez, Isabel, Fernández-Capitan, Carmen, Guerra-Pastrián, Laura, Martín-Sánchez, Carolina, Montiel, Carmen, Ríos, Juan José   +10 more
core   +3 more sources

Calcium imaging with genetically encoded sensor Case12: Facile analysis of α7/α9 nAChR mutants.

PLoS ONE, 2017
Elucidation of the structural basis of pharmacological differences for highly homologous α7 and α9 nicotinic acetylcholine receptors (nAChRs) may shed light on their involvement in different physiological functions and diseases.
Irina Shelukhina, Ekaterina Spirova, Denis Kudryavtsev, Lucy Ojomoko, Markus Werner, Christoph Methfessel, Michael Hollmann, Victor Tsetlin   +7 more
doaj   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development. [PDF]

, 2013
RationaleImpaired cognitive abilities are a key characteristic of schizophrenia. Although currently approved pharmacological treatments have demonstrated efficacy for positive symptoms, to date no pharmacological treatments successfully reverse cognitive
Acheson, Dean T, Twamley, Elizabeth W, Young, Jared W   +2 more
core   +2 more sources

Potentiation and allosteric agonist activation of α7 nicotinic acetylcholine receptors: binding sites and hypotheses

Pharmacological Research, 2023
Considerable progress has been made in recent years towards the identification and characterisation of novel subtype-selective modulators of nicotinic acetylcholine receptors (nAChRs).
Victoria R. Sanders, Neil S. Millar
doaj   +1 more source

Sustained increase of alpha7 nicotinic receptors and choline-induced improvement of learning deficit in STOP knock-out mice. [PDF]

, 2007
International audienceMice deficient in the microtubule stabilizing protein STOP (stable tubule only polypeptide) show synaptic plasticity anomalies in hippocampus, dopamine hyper-reactivity in the limbic system and severe behavioral deficits.
Andrieux, Annie, Bouvrais-Veret, Caroline, Giros, Bruno, Job, Didier, Martres, Marie-Pascale, McIntosh, J Michael, Schweitzer, Annie, Weiss, Stéphanie   +7 more
core   +3 more sources

Neuroinflammation Modulation via α7 Nicotinic Acetylcholine Receptor and Its Chaperone, RIC-3

Molecules, 2021
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in or on various cell types and have diverse functions. In immune cells nAChRs regulate proliferation, differentiation and cytokine release.
Tehila Mizrachi, Adi Vaknin-Dembinsky, Talma Brenner, Millet Treinin   +3 more
doaj   +1 more source

The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? [PDF]

, 2009
Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons.
Elgoyhen, Ana Belen, Fuchs, Paul A., Katz, Eleonora   +2 more
core   +1 more source

Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence. [PDF]

, 2020
Tobacco dependence is a leading cause of preventable disease and death worldwide. Nicotine, the main psychoactive component in tobacco cigarettes, has also been garnering increased popularity in its vaporized form, as derived from e-cigarette devices ...
A Ashoor, A Kuryatov, A Loukola, A Loukola, A Markou, A Pandhare, AA George, AA Strasser, AB Tekinay, AC Harris, AC Villanti, AJ Lanca, AJ Law, AK Stoker, AR Tapper, AT Peana, B Forget, B Froeliger, B Le Foll, B Lenz, BJ Hall, BJ Henderson, CD Fowler, CD Fowler, CDC, CJ Livingston, CL Walters, CL Walters, CM Flores, D Bagdas, D Carmelli, D Gonzales, D Ji, D John, D Vullhorst, DB Vazquez-Sanroman, DC Perry, DK Williams, E Wada, EC Pittaras, ED Claus, EE DeVito, EJ Nestler, EN Lyukmanova, FI Carroll, FJ McClernon, G Di Chiara, G Kong, G Schoenbaum, GS Portugal, H Xian, HD Mansvelder, I Ibanez-Tallon, J Hartmann-Boyce, J Hartmann-Boyce, J Ramirez-Latorre, J Tang, JA Dani, JA Dani, JA Hill Jr, JA Wilking, JE Lisman, JJ Couey, JM Miwa, JM Miwa, JM Miwa, JM Williams, JP Changeux, JR Turner, JR Turner, JR Turner, JS Fowler, JS Fowler, JW Kenney, JZ Liu, KA Garrison, KJ Clemens, KJ Jackson, KJ Jackson, KJ Jackson, KJ Jackson, KP Cosgrove, KS Kendler, KS Okuyemi, L Lagostena, L Zhou, LJ Bierut, LM Tuesta, LP Dwoskin, LP Dwoskin, M Alkondon, M Alkondon, M Arvaniti, M De Biasi, M Foddai, M Kallupi, M Kassiou, M Yuan, M Zhang, MD Li, MI Damaj, MJ Marks, MJ Orejarena, ML Fisher, ML Goniewicz, MP Demars, MR Picciotto, MS Thomsen, MT Bardo, N Champtiaux, N Omelchenko, NI Nissen, NL Benowitz, NL Saccone, O Salminen, P Fagan, P Li, P Truman, PF Sullivan, PJ Welsby, R Girod, R Klink, R Miech, R Salas, R Srinivasan, RL Ashare, RS Caraballo, S Dodd, S Jones, S Kuhn, S Nakauchi, S Pons, S Tonstad, SD Alsharari, SD Alsharari, SS Sanjakdar, TT Smith, U Broms, U Maskos, V Gerzanich, W Berrettini, WA Corrigall, WD Myers, X Pang, Y Li, YY Huang, Z Jin   +146 more
core   +1 more source

Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation

Frontiers in Neuroscience
Nicotinic receptor signaling is influential in modulating appropriate responses to salient stimuli within a complex environment. The cholinergic neurotransmitter system drives attention to salient stimuli such as stressors, and aids in orchestrating the ...
Kristin R. Anderson, Peter J. Rogu, Talulla B. Palumbo, Julie M. Miwa   +3 more
doaj   +1 more source