Results 81 to 90 of about 14,399 (162)

Agonist and antagonist effects of tobacco-related nitrosamines on human α4β2 nicotinic acetylcholine receptors [PDF]

, 2015
Regulation of the ‘neuronal’ nicotinic acetylcholine receptors (nAChRs) is implicated in both tobacco addiction and smoking-dependent tumor promotion.
Andrea Becchetti, Paola Ambrosi, Simone Brusco, Simone Meneghini   +3 more
core   +2 more sources

Symmetry-adapted Markov state models of closing, opening, and desensitizing in α 7 nicotinic acetylcholine receptors

Nature Communications
α7 nicotinic acetylcholine receptors (nAChRs) are homopentameric ligand-gated ion channels with critical roles in the nervous system. Recent studies have resolved and functionally annotated closed, open, and desensitized states of these receptors ...
Yuxuan Zhuang, Rebecca J. Howard, Erik Lindahl   +2 more
doaj   +1 more source

Lidocaine effects on acetylcholine-elicited currents from mouse superior cervical ganglion neurons [PDF]

, 2013
Lidocaine is a commonly used local anaesthetic that, besides blocking voltage-dependent Na+ channels, has multiple inhibitory effects on muscle-type nicotinic acetylcholine (ACh) receptors (nAChRs).
Alberola-Die, Armando, Lamas, J. Antonio, Morales, Andrés, Reboreda, Antonio   +3 more
core   +2 more sources

Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria.

PLoS ONE, 2012
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate synaptic transmission in the muscle and autonomic ganglia and regulate transmitter release in the brain.
Galyna Gergalova, Olena Lykhmus, Olena Kalashnyk, Lyudmyla Koval, Volodymyr Chernyshov, Elena Kryukova, Victor Tsetlin, Sergiy Komisarenko, Maryna Skok   +8 more
doaj   +1 more source

Rationally designed α-conotoxin analogues maintained analgesia activity and weakened side effects [PDF]

, 2019
A lack of specificity is restricting the further application of conotoxin from Conus bullatus (BuIA). In this study, an analogue library of BuIA was established and virtual screening was used, which identified high α7 nicotinic acetylcholine receptor ...
Gao, Xinmei, Grieco, Paolo, Liu, Chen, Qi, Weiyan, Wang, Dong, Wu, Guiyue, Wu, Pengxiang, Xu, Hanmei, Yu, Ruihe, Zhu, He   +9 more
core   +1 more source

Multitarget drug design strategy in Alzheimer’s disease: focus on cholinergic transmission and amyloid-β aggregation [PDF]

, 2017
Background: Alzheimer pathogenesis has been associated with a network of processes working simultaneously and synergistically. Over time, much interest has been focused on cholinergic transmission and its mutual interconnections with other active players
Abu, Izuddin F., Andrisano, Vincenza, Bartolini, Manuela, Bergamini, Christian, Blockley, Alix, Bottegoni, Giovanni, Caporaso, Roberta, Cavalli, Andrea, Gotti, Cecilia, Mellor, Ian R., Minarini, Anna, Rosini, Michela, Simoni, Elena   +12 more
core   +2 more sources

SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors. [PDF]

J Biol Chem, 2023
O'Brien BCV, Weber L, Hueffer K, Weltzin MM.   +3 more
europepmc   +1 more source

Subtype-Selective Peptide and Protein Neurotoxic Inhibitors of Nicotinic Acetylcholine Receptors Enhance Proliferation of Patient-Derived Glioblastoma Cell Lines

Toxins
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, with a poor prognosis. GBM cells, which develop in the environment of neural tissue, often exploit neurotransmitters and their receptors to promote their own growth and invasion ...
Elena Gondarenko, Diana Mazur, Marina Masliakova, Yana Ryabukha, Igor Kasheverov, Yuri Utkin, Victor Tsetlin, Mikhail Shahparonov, Denis Kudryavtsev, Nadine Antipova   +9 more
doaj   +1 more source

Editorial Note: HIV gp120 Induces Mucus Formation in Human Bronchial Epithelial Cells through CXCR4/α7-Nicotinic Acetylcholine Receptors. [PDF]

PLoS One, 2023
PLOS ONE Editors.
europepmc   +1 more source

Structural differences determine the relative selectivity of nicotinic compounds for native α4β2^*-, α6β2^*-, α3β4^*- and α7-nicotine acetylcholine receptors [PDF]

, 2010
Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and pharmacological and functional properties.
Bencherif, Merouane, Breining, Scott R., Drenan, Ryan M., Fedorov, Nikolai B., Grady, Sharon R., Lester, Henry A., Marks, Michael J., McKinney, Sheri, Wageman, Charles R., Whiteaker, Paul, Yohannes, Daniel   +10 more
core