11C-PIB PET/CT在阿尔茨海默病和轻度认知障碍患者中的诊断应用研究
Zhongguo shiyan zhenduanxue目的分析11C-PIB PET/CT在各脑区的标准摄取值比（SUVR）与简易精神状态量表（MMSE）评分的相关性，探索其在阿尔茨海默病（AD）不同疾病阶段中的应用价值。方法纳入2018年12月至2024年12月期间32例患者（AD组21例，轻度认知障碍组11例），使用3D Slicer软件对11C-PIB PET/CT图像进行处理，统计得到各脑区的SUVR值，将各脑区SUVR值进行组间比较，可以得到具有显著差异的脑区，并将这些脑区的SUVR值与MMSE量表分值进行相关性分析 ...
田熙铭 +5 more
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Zhongshan Daxue xuebao. Yixue kexue ban阿尔茨海默病（AD）是老年性痴呆症中最常见的形式，其发病机制仍不清楚，但β淀粉样蛋白（Aβ）被认为是引起AD发病的重要原因，然而其引发AD的病理机制同样存在多种争议。最近研究显示，髓系细胞触发受体（TREM2）在AD病理进程中扮演重要角色，其不仅可以作为Aβ内化的重要受体，还可能成为生物学诊断标志物和治疗靶点，阐明TREM2的结构和功能，将为AD的防治提供重要的思路。本文将从TREM2的结构、TREM2对小胶质细胞功能的影响、TREM2在AD中的病理学作用以及靶向TREM2治疗AD的现状进行系统性综述 ...
代玉婷, 石镜明
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Beta-amyloid protein regulates miR-15a and activates Bag5 to influence neuronal apoptosis in Alzheimer's disease. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanPan Q, Hu X, Guo K.
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血清GFAP、Hcy、Tau联合检测对脑白质病变患者β淀粉样蛋白升高的预测价值
Zhongguo shiyan zhenduanxue目的评价胶质纤维酸性蛋白(GFAP)、同型半胱氨酸(Hcy)、微管相关蛋白(Tau)联合检测对脑白质病变患者β淀粉样蛋白(Aβ)水平升高的预测价值。方法选取上海市杨浦区控江医院收治的80例脑白质病变患者作为研究对象，依据11C-PIB PET显像结果将患者分为Aβ阳性组及Aβ阴性组，分别测定两组患者血清GFAP、Hcy、Tau水平及Aβ沉积半定量评分，分析GFAP、Hcy及Tau与Aβ沉积半定量评分相关性；多因素Logistic回归分析脑白质病变患者Aβ升高危险因素，受试者工作特征曲线(ROC ...
方玲 +5 more
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[Analysis of dietary composition in patients with liver cirrhosis: an observational study based on the database from the National Health and Nutrition Examination survey]. [PDF]
Zhonghua Gan Zang Bing Za ZhiChen XY +6 more
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[Clinical Manifestations of Childhood Systemic Lupus Erythematosus-associated Acute Pancreatitis and Evaluation of the Efficacy of Plasma Exchange Combined With Glucocorticoids]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanXiong L, Guo H.
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[Proteomics analysis of the effect and mechanism of ADSCs on full-thickness skin defects in diabetic rats]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiGu Y, Chen YZ, Wang SY, Song HY, Bai N.
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[<i>Yiqi Jiedu</i> Formula inhibits proliferation, invasion and migration of nasopharyngeal carcinoma cells by inhibiting the AKT1/GLUT1 signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoXu H +8 more
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[Silybin inhibits fibrosis after glaucoma filtration surgery in rabbits by promoting fibroblast autophagy]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhang Y +5 more
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[Whole Exome Sequencing Identified Novel Pathogenic Mutations of <i>ADGB</i> in Patients With Oligoasthenozoospermia]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanWang Q, Yang Y, Jiang C, Shen Y.
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