Zhongshan Daxue xuebao. Yixue kexue ban阿尔茨海默病（AD）是老年性痴呆症中最常见的形式，其发病机制仍不清楚，但β淀粉样蛋白（Aβ）被认为是引起AD发病的重要原因，然而其引发AD的病理机制同样存在多种争议。最近研究显示，髓系细胞触发受体（TREM2）在AD病理进程中扮演重要角色，其不仅可以作为Aβ内化的重要受体，还可能成为生物学诊断标志物和治疗靶点，阐明TREM2的结构和功能，将为AD的防治提供重要的思路。本文将从TREM2的结构、TREM2对小胶质细胞功能的影响、TREM2在AD中的病理学作用以及靶向TREM2治疗AD的现状进行系统性综述 ...
代玉婷, 石镜明
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血清GFAP、Hcy、Tau联合检测对脑白质病变患者β淀粉样蛋白升高的预测价值
Zhongguo shiyan zhenduanxue目的评价胶质纤维酸性蛋白(GFAP)、同型半胱氨酸(Hcy)、微管相关蛋白(Tau)联合检测对脑白质病变患者β淀粉样蛋白(Aβ)水平升高的预测价值。方法选取上海市杨浦区控江医院收治的80例脑白质病变患者作为研究对象，依据11C-PIB PET显像结果将患者分为Aβ阳性组及Aβ阴性组，分别测定两组患者血清GFAP、Hcy、Tau水平及Aβ沉积半定量评分，分析GFAP、Hcy及Tau与Aβ沉积半定量评分相关性；多因素Logistic回归分析脑白质病变患者Aβ升高危险因素，受试者工作特征曲线(ROC ...
方玲 +5 more
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Beta-amyloid protein regulates miR-15a and activates Bag5 to influence neuronal apoptosis in Alzheimer's disease. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanPan Q, Hu X, Guo K.
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[Proteomics analysis of the effect and mechanism of ADSCs on full-thickness skin defects in diabetic rats]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiGu Y, Chen YZ, Wang SY, Song HY, Bai N.
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[<i>Poria cocos</i> polysaccharide alleviates cyclophosphamide-induced intestinal barrier dysfunction and inflammation in mice by modulating gut flora]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhang Y +10 more
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[Association between Tau protein deposition and brain metabolites: N-acetylaspartate and creatine as potential biomarkers for advanced Alzheimer's disease]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLi X +7 more
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Zhongshan Daxue xuebao. Yixue kexue banβ淀粉样蛋白（Aβ）被认为是阿尔茨海默病（AD）的主要致病因素之一。然而，近年研究表明，Aβ可激活小胶质细胞和星形胶质细胞，引发神经炎症反应。神经炎症在神经元死亡过程中起关键作用，并可视为AD发生的深层机制。此外，早在20多年前便有学者提出脑血管损伤在AD发病机制中具有重要作用，但较少有研究关注其积极意义。近年来，越来越多证据表明脑微血管损伤会促使AD发生。最新研究还指出，脑微血管损伤引发的炎症同样是AD发展的重要风险因素。在受损的微血管中，C反应蛋白（CRP）是一种非特异性炎症标志物 ...
张洁, 朱益宜
doaj
[Analyzing the influential factors of dietary patterns and blood glucose control in type 2 diabetes patients based on the model of health action process approach model]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanMin H, Wu Y, Shi Y, Li M, Sun X.
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[Biological activities of <i>Polygonatum</i> polysaccharides and their roles in the prevention and treatment of related diseases]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanGuan P +5 more
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[He<b>'</b>s Yangchao recipe ameliorates premature ovarian insuf-ficiency by remodeling intestinal microbiota to promote granulosa cell glycolysis]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanLin F +6 more
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