β淀粉样蛋白(Aβ)被认为是阿尔茨海默病(AD)的主要致病因素之一。然而,近年研究表明,Aβ可激活小胶质细胞和星形胶质细胞,引发神经炎症反应。神经炎症在神经元死亡过程中起关键作用,并可视为AD发生的深层机制。此外,早在20多年前便有学者提出脑血管损伤在AD发病机制中具有重要作用,但较少有研究关注其积极意义。近年来,越来越多证据表明脑微血管损伤会促使AD发生。最新研究还指出,脑微血管损伤引发的炎症同样是AD发展的重要风险因素。在受损的微血管中,C反应蛋白(CRP)是一种非特异性炎症标志物 ...
张洁, 朱益宜
doaj
[A case of segmental atrophy of the liver in children]. [PDF]
Qiu YL, Mao Y, Lu CL.
europepmc +1 more source
[Association between Tau protein deposition and brain metabolites: N-acetylaspartate and creatine as potential biomarkers for advanced Alzheimer's disease]. [PDF]
Li X +7 more
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[<i>Poria cocos</i> polysaccharide alleviates cyclophosphamide-induced intestinal barrier dysfunction and inflammation in mice by modulating gut flora]. [PDF]
Zhang Y +10 more
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Value of nuclide scintigraphy in the diagnosis and prognosis of cardiac amyloidosis. [PDF]
Mo Q, Deng Z, Xiao Y, Liu C, Zhao M.
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[Plasma metabolites mediates the causal effect of inflammatory proteins on Alzheimer's disease: a Mendelian randomization study]. [PDF]
Chen M, Huang R, Yang Z.
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[Analyzing the influential factors of dietary patterns and blood glucose control in type 2 diabetes patients based on the model of health action process approach model]. [PDF]
Min H, Wu Y, Shi Y, Li M, Sun X.
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阿尔茨海默病(AD)是一种与衰老相关的神经退行性疾病,其特征为神经纤维缠结、β-淀粉样蛋白(Aβ)斑块累积以及神经元死亡。这些病理改变导致了患者认知功能的逐渐衰退,最终影响日常生活能力。目前,AD的治疗手段相对有限,药物干预效果不佳且常伴有副作用。因此研究非药物治疗,特别是营养干预,显得尤为重要。ω-3多不饱和脂肪酸(ω-3PUFAs)是一类对健康至关重要的脂肪酸,主要存在于鱼油和某些植物油中。它们在抗炎、抗氧化、神经保护和免疫调节方面发挥着关键作用。流行病学证据和临床试验表明,ω ...
孙晨枫, 任彬彬
doaj
[Biological activities of <i>Polygonatum</i> polysaccharides and their roles in the prevention and treatment of related diseases]. [PDF]
Guan P +5 more
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[He<b>'</b>s Yangchao recipe ameliorates premature ovarian insuf-ficiency by remodeling intestinal microbiota to promote granulosa cell glycolysis]. [PDF]
Lin F +6 more
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