Results 111 to 120 of about 2,431,497 (250)

Degradation rates and pathways of ciprofloxacin with a composite of β-Ga2O3 nanoparticles and nanocellulose hydrolyzed from Azanza garckeana fruit fibers

Nanocomposites
The photocatalytic degradation of Ciprofloxacin (CIP) was evaluated under ultraviolet photo irradiation and a composite of β-Ga2O3 with nanocellulose citrate-capped fibers (CNCFs) at an 80:20 weight ratio (β-Ga2O3/20%CNCFs).
Maphai Maake, Irvin Noel Booysen, Allen Mambanda   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Asymmetric synthesis of β-amino acids and α-deuterated β-amino acids via conjugate addition of homochiral amidocuprates

, 1995
Sewald N, Hiller KD, Helmreich B. Asymmetric synthesis of β-amino acids and α-deuterated β-amino acids via conjugate addition of homochiral amidocuprates. Liebigs Ann. Chem.
Hiller, Klaus D., Helmreich, Brigitte, Norbert Sewald, Klaus D. Hiller, Sewald, Norbert ; https://orcid.org/, Brigitte Helmreich   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Nova metodologia de bromação dos adutos de morita-baylishillman E sua utilização como intermediários sintéticos na Preparação de heterociclos [PDF]

, 2008
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.Neste trabalho será apresentada uma nova metodologia sintética simples e eficiente para a preparação de (Z)-2-(bromometil)-2-alcenoatos a
FERREIRA, Misael
core  

Transamination of fluorinated β-keto carboxylic esters. A biomimetic approach to β-polyfluoroalkyl-β-amino acids.

, 1993
The base-catalyzed isomerization of N-benzylimines (or enamines) of β-polyfluoroalkyl-β-ketocarboxylic esters cleanly affords the N-benzylidene derivatives of β-polyfluoro-β-aminocarboxylic esters which are hydrolyzed to corresponding amino acids in high
V. P. Kukhar, RESNATI, GIUSEPPE, Giuseppe Resnati, Valery P. Kukhar', A. G. Kirilenko, Vadim A. Soloshonok, Alexander G. Kirilenko, V. A. Soloshonok   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Enantioselective Synthesis of α,β-Disubstituted-β-amino Acids

, 2016
Highly diastereoselective and enantioselective addition of N-benzylhydroxylamine to imides 17 and 20−30 produces α,β-trans-disubstituted N-benzylisoxazolidinones 19 and 31−41. These reactions proceed in 60−96% ee with 93−99% de's using 5 mol % of Mg(NTf2)
Mukund P. Sibi (1633159), Sandeep G. Ghorpade (2993991), Craig P. Jasperse (1633156), Narayanasamy Prabagaran (2535025)   +3 more
core   +1 more source