Results 91 to 100 of about 761,437 (260)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Aza-Amino Acids Disrupt β-Sheet Secondary Structures
Molecules, 2019 Cα to N substitution in aza-amino acids imposes local conformational constraints, changes in hydrogen bonding properties, and leads to adaptive chirality at the nitrogen atom. These properties can be exploited in mimicry and stabilization of peptide
Michael A. McMechen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Effect of sympathomimetic compounds with Β-adrenergic effects on plasma free fatty acids in man
Journal of Lipid Research, 1966 Nine sympathomimetic compounds were infused intravenously in man, and their effects on the level of plasma free fatty acids, pulse rate, and blood pressure were recorded. Each compound raised the level of plasma free fatty acids.
T.R.E. Pilkington +4 more
doaj +1 more source
Dynamic Evolution of Bitterness Units in Beer Worts: Modeling and Concerns [PDF]
, 2021 Beer bitterness is reported in International Bitterness Units (IBU), which is the concentration (in ppm) of iso-alpha-acids in the product. Such acids result from the isomerization of alpha-acids originally found in hops which is carried out by boiling ...
Bojorge, Ninoska +4 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Hop bioactive compounds: spontaneous vs commercial varieties [PDF]
, 2019 Humulus lupulus L. is a species belonging to the Cannabaceae family. Hop, as it is commonly known, is a perennial, dioecious and normally diploid (2n = 20) herbaceous plant.
Goes, Hugo +4 more
core
The Memory of Hops: Rural Bioculture as a Collective Means of Reimagining the Future [PDF]
[EN] This article, set within an art–science collaborative framework, exposes a multidisciplinary research platform aimed at identifying new relationships with hops (Humulus lupulus), its harvest, and local memory.
Acedo Casado, María Carmen +8 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source