Results 81 to 90 of about 761,437 (260)

Targeted analysis of polyphenol metabolism during development of hop (Humulus lupulus L.) cones following treatment with prohexadione-calcium [PDF]

, 2014
Hops (Humulus lupulus), a main ingredient in beer, are valued as a source of bitter flavour and biologically active polyphenols. We treated immature hop cones with prohexadione-calcium (Pro-Ca), a flavanone-3-hydroxylase (F3H) inhibitor, to perturb the ...
Figueroa Saldivar, Mario, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

A study of dynamics of bitter acids and xanthohumol in hop pellets during storage [PDF]

, 2018
ArticleEight varieties of hop pellets were analyzed for the contents of α - acids, ß - acids and xanthohumol according to the EBC 7.7 analytical method. The pellets were extracted with acidified mixture methanol - diethylether and
Chládek, L., Hejtmánková, A., Hlavatá, E., Táborský, J.   +3 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Copper-catalyzed multicomponent reaction of β-trifluoromethyl β-diazo esters enabling the synthesis of β-trifluoromethyl N,N-diacyl-β-amino esters

Beilstein Journal of Organic Chemistry
An efficient multicomponent reaction of newly designed β-trifluoromethyl β-diazo esters, acetonitrile, and carboxylic acids via an interrupted esterification process under copper-catalyzed conditions has been developed, which affords various ...
Youlong Du, Haibo Mei, Ata Makarem, Ramin Javahershenas, Vadim A. Soloshonok, Jianlin Han   +5 more
doaj   +1 more source

The Synthesis and Role of β-Alanine in Plants

Frontiers in Plant Science, 2019
Most studies on amino acids are focused on the proteinogenic amino acids given their essential roles in protein synthesis among other pathways.
Anutthaman Parthasarathy, Michael A. Savka, André O. Hudson   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The effect of bile and bile salts on the uptake and cleavage of β-carotene into retinol ester (vitamin A ester) by intestinal slices

Journal of Lipid Research, 1964
Bile of the rat and of other species stimulates the uptake of β-carotene from a micellar solution of Tween 40 (polyoxyethylene anhydrosorbitol monopalmitate) and its cleavage into retinol ester by intestinal sections of the rat incubated in vitro. Sodium
James Allen Olson
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

β‐Amino Acid Synthesis Using the CO2 Radical Anion under Electrochemical and Photochemical Conditions

ChemistryEurope
The development of sustainable and efficient routes to β‐ and γ‐amino acids is urgent due to their pivotal importance in pharmaceuticals and materials science. This study presents a novel approach utilizing the CO2 radical anion as a key intermediate for
Tavinder Singh, Yamato Ueno, Kosaku Tanaka III, Wataru Kanna, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita   +6 more
doaj   +1 more source

Thermal deterioration of the trans-/cis-ratio of bittering agents of commercial beers [PDF]

, 2011
Producción CientíficaThe use of reduced isomerised hop extracts to achieve both bitterness and light stability became very popular during the last decade. Changes during storage in four hop extracts and seven commercial lager beers are studied using HPLC
Blanco Fuentes, Carlos Antonio, Buffa Dunat, Martín, Caballero Caballero, Isabel   +2 more
core   +1 more source