Results 81 to 90 of about 2,431,497 (250)

Localization of nervonic acid β-oxidation in human and rodent peroxisomes: impaired oxidation in Zellweger syndrome and X-linked adrenoleukodystrophy

Journal of Lipid Research, 1998
Studies with purified subcellular organelles from rat liver indicate that nervonic acid (C24:1) is β-oxidized preferentially in peroxisomes. Lack of effect by etomoxir, inhibitor of mitochondrial β-oxidation, on β-oxidation of lignoceric acid (C24:0), a ...
Rajat Sandhir, Mushfiquddin Khan, Amarjit Chahal, Inderjit Singh   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, Volume 600, Issue 18, Page 2686-2694, September 2026.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Ribosomal Synthesis of Peptides with Multiple β‑Amino Acids

, 2016
The compatibility of β-amino acids with ribosomal translation was studied for decades, but it has been still unclear whether the ribosome can accept various β-amino acids, and whether the ribosome can introduce multiple β-amino acids in a peptide. In the
Yuki Goto (251586), Hiroshi Murakami (227877), Hiroaki Suga (295809), Tomoshige Fujino (1403092)   +3 more
core   +1 more source

β‐Amino Acid Synthesis Using the CO2 Radical Anion under Electrochemical and Photochemical Conditions

ChemistryEurope
The development of sustainable and efficient routes to β‐ and γ‐amino acids is urgent due to their pivotal importance in pharmaceuticals and materials science. This study presents a novel approach utilizing the CO2 radical anion as a key intermediate for
Tavinder Singh, Yamato Ueno, Kosaku Tanaka III, Wataru Kanna, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita   +6 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Pharmacogenetics of ophthalmic topical β-blockers [PDF]

, 2008
Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
Smith, Edward M., Wilke, Russell A., Sidjanin, Duska J., McCarty, Catherine A., Patchett, Richard   +4 more
core   +1 more source

The effect of bile and bile salts on the uptake and cleavage of β-carotene into retinol ester (vitamin A ester) by intestinal slices

Journal of Lipid Research, 1964
Bile of the rat and of other species stimulates the uptake of β-carotene from a micellar solution of Tween 40 (polyoxyethylene anhydrosorbitol monopalmitate) and its cleavage into retinol ester by intestinal sections of the rat incubated in vitro. Sodium
James Allen Olson
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Aza-Amino Acids Disrupt β-Sheet Secondary Structures

Molecules, 2019
Cα to N substitution in aza-amino acids imposes local conformational constraints, changes in hydrogen bonding properties, and leads to adaptive chirality at the nitrogen atom. These properties can be exploited in mimicry and stabilization of peptide
Michael A. McMechen, Evan L. Willis, Preston C. Gourville, Caroline Proulx   +3 more
doaj   +1 more source