Results 61 to 70 of about 1,157,409 (244)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans

, 2020
Purpose: Chronic β-alanine supplementation leads to increased levels of muscle histidine-containing dipeptides. However, the majority of ingested β-alanine is, most likely, degraded by two transaminases: GABA-T and AGXT2.
Hautekiet, Arne00009063710391902550221321FBB678-F0EE-11E1-A9DE-61C894A0A6B4, de Jager, Sarah0001105712098020027604929774322385153971FABA-F0EE-11E1-A9DE-61C894A0A6B4, Hautekiet, Arne, Blancquaert, Laura, Stautemas, JanGE370000902521338020017014750000-0001-7473-93401EB6F6BC-F0EE-11E1-A9DE-61C894A0A6B4, Volkaert, AnnekeGE30801001021587F4EB187C-F0ED-11E1-A9DE-61C894A0A6B4, Derave, Wim, Blancquaert, Laura0000704944458020010554179190228163230000-0001-6996-1393088CC63C-F0EE-11E1-A9DE-61C894A0A6B4, Shan, Zhou Xiang, Weiss, Norbert, Stautemas, Jan, Everaert, IngeUGent0020041081088020004576539756300001370000-0002-1800-4355FB7033E4-F0ED-11E1-A9DE-61C894A0A6B4, Kim, Chang Keun, Croubels, SiskaCA05DI058010008843730000-0001-6357-3517F4AAFB84-F0ED-11E1-A9DE-61C894A0A6B4, De Baere, SiegridDI05801000884777F4AB75B4-F0ED-11E1-A9DE-61C894A0A6B4, Derave, WimGE308010010317920000-0002-2225-5587F4EF24F8-F0ED-11E1-A9DE-61C894A0A6B4, De Baere, Siegrid, Bode-Boeger, Stefanie M., Croubels, Siska, de Jager, Sarah, Lefevere, Filip801001059781919014958212C21FC478-49B6-11E4-AA90-F166B5D1D7B1, Volkaert, Anneke, Rodionov, Roman N., Jarzebska, Natalia, Everaert, Inge, Martens-Lobenhoffer, Jens, Leiper, James, Lefevere, Filip   +27 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Effects of Four Weeks of β-Alanine Supplementation on Repeated Sprint Ability in Water Polo Players. [PDF]

PLoS ONE, 2016
The purpose of this study was to investigate the effect of four weeks of β-alanine supplementation on repeated sprint ability in water polo players.
Gabriel Motta Pinheiro Brisola, Guilherme Giannini Artioli, Marcelo Papoti, Alessandro Moura Zagatto   +3 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Cellular and Physiological Effects of Dietary Supplementation with β-Hydroxy-β-Methylbutyrate (HMB) and β-Alanine in Late Middle-Aged Mice. [PDF]

PLoS ONE, 2016
There is growing evidence that severe decline of skeletal muscle mass and function with age may be mitigated by exercise and dietary supplementation with protein and amino acid ingredient technologies.
Julian Vallejo, Madoka Spence, An-Lin Cheng, Leticia Brotto, Neile K Edens, Sean M Garvey, Marco Brotto   +6 more
doaj   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

β-Alanine Supplementation and its Effect on Sports Performance

, 2023
β-alanine is a commonly used supplement within the realm of athletics. Although it is produced in the human liver and found in poultry and meats, supplementation in higher amounts appears to affect athletic performance positively.
Bernhardt, Will
core  

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

Advanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy, Kyle B. Meerbott, Lorenzo Travaglini, Garima S. Dobhal, Artur Sawicki, Marc R. Knecht, Tiffany R. Walsh, Dominic J. Glover   +7 more
wiley   +1 more source