Results 91 to 100 of about 19,422 (160)

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

Decoding functional specialization in G protein‐coupled receptors (GPCRs) through evolution‐guided residue profiling

British Journal of Pharmacology, Volume 183, Issue 20, Page 6007-6027, October 2026.
Background and Purpose G protein‐coupled receptors (GPCRs) are integral membrane proteins that mediate physiological processes by enabling cells to detect and respond to diverse stimuli. Although many subfamily‐specific functional hotspots have been described, the family‐wide determinants of common and subfamily‐specific functions remain incomplete ...
Berkay Selçuk, Gunnar Schulte, Igor B. Zhulin, Ogün Adebali   +3 more
wiley   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Predictors of in vitro response to somatostatin and dopamine receptor‐targeted treatments are lacking in clinically non‐functioning pituitary tumors

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Clinically non‐functioning pituitary neuroendocrine tumors (NF‐PitNETs) lack effective medical therapies, and the role of somatostatin receptor ligands (SRLs) and dopamine agonists (DAs) in this setting is controversial. We evaluated the in vitro response of NF‐PitNETs to multiple SRL and/or DA treatments, focusing on the role of receptor ...
Claudia Campana, Jessica Amarù, Diego Criminelli Rossi, Anna Arecco, Paolo Nozza, Mara Boschetti, Gianluigi Zona, Diego Ferone, Marica Arvigo, Federico Gatto   +9 more
wiley   +1 more source

Identification of Entacapone as a Novel β-Arrestin 1 Biased Antagonist of CXCR7. [PDF]

Molecules
Shi L, Huang Y, Li L, Li H, Li X, Bi Z, Liu J, Zhang S, Cong Z, Wang B, Chen S.   +10 more
europepmc   +1 more source

β-Arrestin-2 Regulates Sodium Taste Processing. [PDF]

Hypertension
Grobe CC, Hamilton AJ, Treesukosol Y, Grobe JL, Segar JL, Sigmund CD.   +5 more
europepmc   +1 more source

β-Arrestin condensates regulate G-protein-coupled receptor function. [PDF]

Nature
Anderson PJ, Xiao P, Zhong YN, Kaakati AN, Alfonso-DeSouza J, Patino A, Ahn A, Jassal C, Zhang T, Zhang C, Yu K, Qi L, Ding W, Liu S, Pani B, Krishnan A, Chen O, Strawn J, Snyder JC, Sun JP, Rajagopal S.   +20 more
europepmc   +1 more source

Structural dynamics of kappa opioid receptor interactions with β-arrestin 1. [PDF]

Nat Commun
Han J, Fine EJ, Jiang Q, Zhuang Y, Suomivuori CM, Chen ZW, Denn E, Whiddon K, Li K, Evers AS, Fuller J, Carter J, Fay JF, Chen M, Dror RO, Che T.   +15 more
europepmc   +1 more source

Factors modulating the assembly of human β₂-adrenergic receptor-β-arrestin complexes. [PDF]

Nat Struct Mol Biol
Wilhelm FM, Pluhackova K, Janetzko J, Masureel M, Marsh E, Hudspeth J, Gaßner W, Schertler GFX, Kobilka BK, Müller DJ.   +9 more
europepmc   +1 more source

Membrane cholesterol modulates engagement of β-arrestin with the ghrelin receptor. [PDF]

Commun Biol
Berto L, Henri P, Damian M, Cantel S, Fehrentz JA, Sibille N, Di Michele M, Banères JL.   +7 more
europepmc   +1 more source