Results 81 to 90 of about 18,493 (159)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, Volume 13, Issue 37, 3 July 2026.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways. [PDF]

Proc Natl Acad Sci U S A, 2021
Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM, Lin HC, Yu X, Sun JP.   +10 more
europepmc   +1 more source

Subcellular Localization of Dopamine D1 and D2 Receptors in the Mouse Hippocampus

Journal of Comparative Neurology, Volume 534, Issue 7, July 2026.
In CA1 and CA3, D1R and D2R labeling localized to pyramidal neuron dendritic spines and axon terminals. D1R‐labeled terminals primarily formed excitatory synapses on spines, whereas D2R‐labeled terminals mainly formed inhibitory synapses on dendritic shafts.
Cameron B. Swope, Garrett Sommer, Ravon Smith, Teresa A. Milner, Jimcy Platholi   +4 more
wiley   +1 more source

The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway

Cells
The recent emphasis on circadian rhythmicity in critical skin cell functions related to homeostasis, regeneration and aging has shed light on the importance of the PER2 circadian clock gene as a vital antitumor gene.
Paul Bigliardi, Seetanshu Junnarkar, Chinmay Markale, Sydney Lo, Elena Bigliardi, Alex Kalyuzhny, Sheena Ong, Ray Dunn, Walter Wahli, Mei Bigliardi-Qi   +9 more
doaj   +1 more source

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, Volume 18, Issue 7, Page 922-932, July 2026.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR. [PDF]

Nat Commun, 2021
Shiraishi Y, Kofuku Y, Ueda T, Pandey S, Dwivedi-Agnihotri H, Shukla AK, Shimada I.   +6 more
europepmc   +1 more source

Tricarboxylic Acid (TCA) Cycle Enzyme Alpha‐Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization

Journal of Cellular Biochemistry, Volume 127, Issue 7, July 2026.
ABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Meijing Li, Ryan J. Mailloux
wiley   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 644-671, July/August 2026.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis. [PDF]

Carcinogenesis, 2021
Adekoya TO, Smith N, Thomas AJ, Lane TS, Burnette N, Rivers EJ, Li Y, Chen XL, Richardson RM.   +8 more
europepmc   +1 more source