Results 101 to 110 of about 18,493 (159)

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, Volume 183, Issue 14, Page 4006-4021, July 2026.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Subtype-dependent arrestin engagement of the metabotropic glutamate receptors

Nature Communications
The arrestin-mediated regulation of signaling through the metabotropic glutamate receptors (mGlus) is fundamental mechanism modulating excitatory transmission and synaptic plasticity.
Shuling Lin, Chenhui Zhang, Jiaxin Wei, Shanshan Li, Jie Yu, Jingyi Xu, Kun Chen, Ye Feng, Ziyu Wang, Xiaojing Chu, Cuiying Yi, Limin Ma, Shuo Han, Wenqing Shui, Qiang Zhao, Beili Wu   +15 more
doaj   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach. [PDF]

J Pers Med, 2022
Al-Hakeim HK, Hadi HH, Jawad GA, Maes M.
europepmc   +1 more source

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells‐Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
In this study, human astrocytes were obtained from induced pluripotent stem cells (iPSCs) of Parkinson's disease (PD) patients carrying the G2019S LRRK2 mutation, the most common genetic cause of PD. These astrocytes display a reactive and inflammatory profile, with increased GFAP levels, elevated cytokine release, and reduced support for dopaminergic ...
Veronica Mutti, Federica Bono, Zaira Tomasoni, Dounia Fadel, Chiara Gnutti, Giulia Sbrini, Carolina Gaudenzi, Valentina Salvi, Daniela Bosisio, Isabella Russo, Silvia Bolognin, Jens C. Schwamborn, Cristina Missale, Chiara Fiorentini   +13 more
wiley   +1 more source

Structure of the neurotensin receptor 1 in complex with β-arrestin 1. [PDF]

Nature, 2020
Huang W, Masureel M, Qu Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK.   +10 more
europepmc   +1 more source

Beneficial metabolic role of β-arrestin-1 expressed by AgRP neurons. [PDF]

Sci Adv, 2020
Pydi SP, Cui Z, He Z, Barella LF, Pham J, Cui Y, Oberlin DJ, Egritag HE, Urs N, Gavrilova O, Schwartz GJ, Buettner C, Williams KW, Wess J.   +13 more
europepmc   +1 more source

Key phosphorylation sites in GPCRs orchestrate the contribution of β-Arrestin 1 in ERK1/2 activation. [PDF]

EMBO Rep, 2020
Baidya M, Kumari P, Dwivedi-Agnihotri H, Pandey S, Chaturvedi M, Stepniewski TM, Kawakami K, Cao Y, Laporte SA, Selent J, Inoue A, Shukla AK.   +11 more
europepmc   +1 more source

miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting β-Arrestin 1. [PDF]

Cells, 2020
Matarese A, Gambardella J, Lombardi A, Wang X, Santulli G.   +4 more
europepmc   +1 more source

β-arrestin-1 suppresses myogenic reprogramming of brown fat to maintain euglycemia. [PDF]

Sci Adv, 2020
Pydi SP, Jain S, Barella LF, Zhu L, Sakamoto W, Meister J, Wang L, Lu H, Cui Y, Gavrilova O, Wess J.   +10 more
europepmc   +1 more source