Results 121 to 130 of about 29,885 (192)
Dual roles of β-arrestin 1 in mediating cell metabolism and proliferation in gastric cancer. [PDF]
Proc Natl Acad Sci U S A, 2022 Yu H +9 more
europepmc +1 more source
Evidence for a Two‐Step Model for Activation of GPR25 by the Chemoattractant CXCL17
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.ABSTRACT CXCL17 was recently reported to activate GPR25, a receptor expressed by T‐regulatory cells. Although classified as a chemokine, the activity of CXCL17 is ablated by minor C‐terminal truncation, suggesting a novel mode of receptor activation. We set out to test this hypothesis by mutagenesis. GPR25 was expressed in the murine pre‐B cell line L1.
Wuqing Yang +2 more
wiley +1 more source
Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways. [PDF]
Proc Natl Acad Sci U S A, 2021 Wang MW +10 more
europepmc +1 more source
eFood, Volume 7, Issue 3, June 2026.Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy +7 more
wiley +1 more source
ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy. [PDF]
, 2019 Background:Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G ...
Beard, Timothy L +10 more
core
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.Abstract Background Mood stabilizer augmentation is frequently used in treatment‐resistant schizophrenia despite limited guideline recommendations. Evidence for its efficacy and safety in the residual phase, however, remains insufficient. Case Presentation A 49‐year‐old Japanese woman with treatment‐resistant residual schizophrenia exhibited persistent
Yoshiki Kasagi +2 more
wiley +1 more source
Protein Science, Volume 35, Issue 6, June 2026.Abstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Álex Pérez‐Sánchez +3 more
wiley +1 more source
Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR. [PDF]
Nat Commun, 2021 Shiraishi Y +6 more
europepmc +1 more source
Intrinsic conformational equilibria position arrestin‐2 for activation
Protein Science, Volume 35, Issue 6, June 2026.Abstract Arrestins regulate G protein‐coupled receptor (GPCR) signaling by undergoing large‐scale conformational rearrangements, yet the solution‐state equilibria that underlie arrestin pre‐activation remain poorly defined. While prior studies identified slow conformational exchange at the interdomain interface, these minor states could not be ...
Tucker J. Shriver +6 more
wiley +1 more source
Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits
British Journal of Pharmacology, Volume 183, Issue 12, Page 3195-3212, June 2026.Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini +9 more
wiley +1 more source