Results 121 to 130 of about 1,643,257 (174)

β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K. [PDF]

Nat Prod Bioprospect
Nie S, Chang L, Huang Y, Zhou H, Yang Q, Kong L, Li Y.   +6 more
europepmc   +1 more source

Rhenium(I) Complexes with 2-(1,2,4-Triazol-5-yl)-<i>β</i>-Carboline-Based Bidentate Luminophores and Neutral Co-Ligands: Towards Tunable Phosphorescence and Efficient Singlet Dioxygen Photoproduction. [PDF]

Int J Mol Sci
Lüke J, Maisuls I, Hepp A, Strassert CA.   +3 more
europepmc   +1 more source

Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer. [PDF]

RSC Med Chem
Fathy A, Allam A, ElHady AK, El-Gamil DS, Lin KC, Chang YH, Lee YH, Hilscher S, Schutkowski M, Ibrahim HS, Chen SH, Chen CH, Abadi AH, Sippl W, Chen PJ, Cheng YS, Abdel-Halim M.   +16 more
europepmc   +1 more source

Design, synthesis and antiproliferative evaluation of tetrahydro-β-carboline histone deacetylase inhibitors bearing an aliphatic chain linker. [PDF]

RSC Adv
Shi J, Wang J, Wang X, Qu C, Ye C, Li X, Chen X, Xu Z.   +7 more
europepmc   +1 more source

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β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities

European Journal of Medicinal Chemistry, 2018
β-Carboline alkaloids are a family of natural and synthetic products with great structural diversity and outstanding biological activities. This review covers critically important developments in the field of β-carbolines, predominantly over the past ...
Jiangkun Dai, Uwe Schneider, Wang Junru   +2 more
exaly   +2 more sources

Identification of 1,3,4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity.

European journal of medicinal chemistry, 2023
In this study, we designed and synthesized a novel class of 1,3,4-oxadiazolyl-containing β-carboline derivatives, i.e., compounds f1∼f35 as potential α-glucosidase inhibitors.
Di Xiao, Li Lu, Bingwen Liang, Zhuang Xiong, Xuetao Xu, Wen-Hua Chen   +5 more
semanticscholar   +1 more source

Current development of β-carboline derived potential antimalarial scaffolds.

European journal of medicinal chemistry, 2023
β-Carboline alkaloids are an eminent class of nitrogen-based natural alkaloids and therapeutic molecules which exert various pharmacological activities through diverse mechanisms. A lot of attention has recently been directed towards this moiety in order
Preeti Kushwaha, Vipin Kumar, B. Saha
semanticscholar   +1 more source

Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

Chemistry and Biodiversity, 2023
his comprehensive review is designed to evaluate the anticancer properties of β‐carbolines derived from medicinal plants, with the ultimate goal of assessing their suitability and potential in cancer treatment, management, and prevention.
P. Tshikhudo, T. Mabhaudhi, N. Koorbanally, F. Mudau, Edgardo Oscar Avendaño Caceres, D. Popa, D. Calina, J. Sharifi‐Rad   +7 more
semanticscholar   +1 more source

A review on β-carboline alkaloids and their distribution in foodstuffs: A class of potential functional components or not?

Food Chemistry, 2021
Pharmacologically active β-carboline alkaloids (βCs) such as harman, norharman and some others are naturally present in plants and occur in many foodstuffs.
Zhejun Xie, Ning Cao, Changhong Wang
semanticscholar   +1 more source

Natural and synthetic β-carboline as a privileged antifungal scaffolds.

European journal of medicinal chemistry, 2021
The discovery of antifungal agents with novel structure, broad-spectrum, low toxicity, and high efficiency has been the focus of medicinal chemists. Over the past decades, β-carboline scaffold has attracted extensive attention in the scientific community ...
Jiang-Kun Dai, Wenjia Dan, J. Wan
semanticscholar   +1 more source