Advanced Science, Volume 13, Issue 50, 7 September 2026.Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan +7 more
wiley +1 more source
A Model of Demasking and Hydrolysis of Peptide Bonds During Tryptic Digestion of β-Casein and β-Lactoglobulin. [PDF]
MoleculesVorob'ev MM.
europepmc +1 more source
Advanced Science, Volume 13, Issue 53, 24 September 2026.eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin +3 more
wiley +1 more source
Protective Effect of Phytic Acid in Cardiovascular Diseases: A Systematic Review
ChemFoodChem, Volume 2, Issue 3, September 2026.ABSTRACT Cardiovascular diseases (CVDs) are a cluster of ailments that impact the heart and blood vessels and are a primary public health problem of mortality on a global scale. Phytic acid, a dietary constituent frequently present in foods like seeds, has been linked to many pharmacological attributes, including anti‐cancer, antioxidant, anti ...
Marta M. S. de Freitas Almeida +7 more
wiley +1 more source
Exploratory identification of coding and splicing-related SNV variants in A1A1 and A2A2 β-casein Holstein dairy cows. [PDF]
J Anim SciJiménez-Montenegro L +2 more
europepmc +1 more source
Gastric Emptying of New-World Milk Containing A1 and A2 Β-Casein Is More Rapid as Compared to Milk Containing Only A2 Β-Casein in Lactose Maldigesters: A Randomized, Cross-Over Trial Using Magnetic Resonance Imaging. [PDF]
Nutrients, 2023 Ramakrishnan M +3 more
europepmc +1 more source
ChemFoodChem, Volume 2, Issue 3, September 2026.Untargeted peptide profiling investigates how S. thermophilus, Lb. bulgaricus, and endogenous milk enzymes impact proteolysis during early‐stage milk fermentation. ≥ 3000 identified peptides show the strongest influence of LB on the peptide profile and number of bioactive peptides. Shorter peptides are mostly formed by LB and hydrolyzed by ST.
Eva Beck +6 more
wiley +1 more source
Dual-Phase Immunomodulation by the Bovine β-Casein Peptide KEMPFPK: Insights into Potential TLR Interaction and Gut Microbiota-Mediated Effects. [PDF]
FoodsZhang J, Zhang X, Wu J, Mu G, Wu X.
europepmc +1 more source
Modification of a previously patented method to unequivocally score A2-like and A1-like bovine β-casein variants. [PDF]
MethodsX, 2023 Raschia MA +3 more
europepmc +1 more source
Food Frontiers, Volume 7, Issue 5, September 2026.Ketogenic diet (KD) confers neuroprotection in Alzheimer's disease by inhibiting microglial HDAC3. This simultaneously enhances Aβ clearance via TREM2‐mediated phagocytosis and AMPK–ULK1‐driven autophagy, while suppressing NLRP3 inflammasome activation, ultimately attenuating Aβ/tau pathology and neuronal damage. ABSTRACT Growing evidence suggests that
Mingxiao Zheng +7 more
wiley +1 more source