Diclofenac-β-cyclodextrin for colonic drug targeting: in vivo performance in rats [PDF]
, 2016 The aim of this in vivo study was to assess the ability of the prodrug conjugate diclofenac-β-cyclodextrin to release diclofenac in the colon following oral administration, using sulfapyridine (a metabolite of sulfasalazine) as a marker of colonic ...
Basit, AW +5 more
core +1 more source
The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes. [PDF]
, 2015 A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been developed to minimize the severe side effects of the poorly water-soluble anticancer drug paclitaxel (PTX) for clinical use.
Chen, R +5 more
core +2 more sources
Influence of feeding regimens on rat gut fluids and colonic metabolism of diclofenac-β-cyclodextrin [PDF]
, 2014 Feeding states may affect the performance of colonic prodrugs. The aim is to investigate the influence of feeding regimen in Wistar rats on: (i) distribution and pH contents along the gut and (ii) metabolism of two colonic prodrugs, diclofenac-β ...
Basit, Abdul W. +5 more
core +1 more source
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity [PDF]
, 2008 NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Cassela +40 more
core +1 more source
Linear cyclodextrin polymer prodrugs as novel yherapeutics for Niemann-Pick type C1 disorder [PDF]
, 2018 Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating ...
Aditya Kulkarni +8 more
core +1 more source
Optimization of β-cyclodextrin-based extraction of antioxidant and anti-browning activities from thyme leaves by response surface methodology [PDF]
, 2018 Thyme (Thymus vulgaris) has been demonstrated to extend the shelf-life of food products, being also a potential source of bioactive compounds. The aim of this research was to optimize the ultrasound assisted extraction employing β-cyclodextrin aqueous ...
Buera, Maria del Pilar +4 more
core +1 more source
Ionic liquids functionalized β-cyclodextrin polymer for separation/analysis of magnolol
Journal of Pharmaceutical Analysis, 2014 Ionic liquids functionalized β-cyclodextrin polymer, a mono-6-deoxy-6-(1,2-dimethylimidazolium)-β-cyclodextrin iodide polymer (ILs-β-CDCP), was synthesized as a solid-phase adsorbent coupled with high-performance liquid chromatography for separating or analyzing magnolol in drug samples.
Nan Zhou, Xia-Shi Zhu
openaire +3 more sources
Perbandingan Aktivitas Antioksidan Ekstrak Etanol 70% Daun Binahong (Anredera Cordifolia, (Ten.) Steenis) Segar Dan Daun Binahong (Anredera Cordifolia, (Ten.) Steenis) Kering Dengan Metode Dpph (2,2-diphenil-1-picryl-hydrazyl) [PDF]
, 2017 Ibuprofen is a nonsteroid anti-inflammatory drug (NSAID) that can inhibit activities of siklooksigenase-1 and siklooksigenase-2 isoenzyme, so thats with inhibiting the changing of arachidonic acid to prostaglandin can be decreased.
Ariyanti, A. (Ariyanti) +2 more
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Fabrication of viable cyborg cells with cyclodextrin functionality [PDF]
, 2013 We describe two alternative methods for surface functionalisation of Saccharomyces cerevisiae cells with cyclodextrin molecules without affecting the cell viability.
Mathapa, Baghali G., Paunov, Vesselin N.
core +2 more sources
Preparation and Characterization of Antibacterial Polypropylene Meshes with Covalently Incorporated β-Cyclodextrins and Captured Antimicrobial Agent for Hernia Repair. [PDF]
, 2018 Polypropylene (PP) light weight meshes are commonly used as hernioplasty implants. Nevertheless, the growth of bacteria within textile knitted mesh intersections can occur after surgical mesh implantation, causing infections. Thus, bacterial reproduction
Li, Yan +5 more
core +6 more sources