Results 31 to 40 of about 2,563,124 (253)

Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2020
The gastrointestinal tract houses a reservoir of bacterial-derived enzymes which can directly catalyze the metabolism of drugs, dietary elements, and endogenous molecules.
J. Walsh, L. Olavarría‐Ramírez, G. Lach, Marcus Boehme, T. Dinan, J. Cryan, B. Griffin, N. Hyland, G. Clarke   +8 more
semanticscholar   +1 more source

Association of fecal microbial diversity and taxonomy with selected enzymatic functions. [PDF]

PLoS ONE, 2012
Few microbial functions have been compared to a comprehensive survey of the human fecal microbiome. We evaluated determinants of fecal microbial β-glucuronidase and β-glucosidase activities, focusing especially on associations with microbial alpha and ...
Roberto Flores, Jianxin Shi, Mitchell H Gail, Pawel Gajer, Jacques Ravel, James J Goedert   +5 more
doaj   +1 more source

A Doxorubicin-Glucuronide Prodrug Released from Nanogels Activated by High-Intensity Focused Ultrasound Liberated β-Glucuronidase [PDF]

, 2020
The poor pharmacokinetics and selectivity of low-molecular-weight anticancer drugs contribute to the relatively low effectiveness of chemotherapy treatments.
Moonen, Chrit T. W., Pharmaceutics, Metselaar, Josbert M., Moonen, Chrit T.W., Scheeren, Hans W., Besse, Helena C., Hans W. Scheeren, Yinan Chen, Twan Lammers, Deckers, Roel, Scheeren, Hans W, Josbert M. Metselaar, Helena C. Besse, Hennink, Wim E., Metselaar, Josbert M, Roel Deckers, Moonen, Chrit T W, Lammers, Twan, Wim E. Hennink, Besse, Helena C, Hennink, Wim E, Afd Pharmaceutics, Chrit T. W. Moonen, Chen, Yinan   +23 more
core   +3 more sources

A thermostable β-glucuronidase obtained by directed evolution as a reporter gene in transgenic plants.

PLoS ONE, 2011
A β-glucuronidase variant, GUS-TR3337, that was obtained by directed evolution exhibited higher thermostability than the wild-type enzyme, GUS-WT. In this study, the utility of GUS-TR337 as an improved reporter was evaluated. The corresponding gus-tr3337
Ai-Sheng Xiong, Ri-He Peng, Jing Zhuang, Jian-Min Chen, Bin Zhang, Jian Zhang, Quan-Hong Yao   +6 more
doaj   +1 more source

Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity

Science Advances, 2019
Toxicity from the immunosuppressant mycophenolate mofetil is prevented by eliminating gut bacteria expressing β-glucuronidase. Mycophenolate mofetil (MMF) is commonly prescribed and has proven advantages over other immunosuppressive drugs.
Michael R. Taylor, K. Flannigan, Hannah Rahim, Amina Mohamud, I. Lewis, S. Hirota, S. Greenway   +6 more
semanticscholar   +1 more source

Theoretical investigation and design of some indole derivatives as potent β-glucuronidase inhibitors

Bulletin of the National Research Centre, 2020
Background β-glucuronidase enzyme is mostly found in plants and animals. It plays a vital role in detoxification of reactive metabolites that are interrelated to several illnesses and the growth of colon cancer.
Muhammad Tukur Ibrahim, Salisu Muhammad Tahir, Abdullahi Bello Umar, Usman Abdulfatai   +3 more
doaj   +1 more source

Upregulation of Jasmonate-Inducible Defense Proteins and Differential Colonization of Roots of Oryza sativa Cultivars with the Endophyte Azoarcus sp.

Molecular Plant-Microbe Interactions, 2006
The endophyte Azoarcus sp. strain BH72 expresses nitrogenase (nif) genes inside rice roots. We applied a proteomic approach to dissect responses of rice roots toward bacterial colonization and jasmonic acid (JA) treatment.
Lucie Miché, Federico Battistoni, Sabrina Gemmer, Maya Belghazi, Barbara Reinhold-Hurek   +4 more
doaj   +1 more source

Therapeutic significance of β-glucuronidase activity and its inhibitors: A review

European journal of medicinal chemistry, 2019
The emergence of disease and dearth of effective pharmacological agents on most therapeutic fronts, constitutes a major threat to global public health and man’s existence.
Paul Awolade, Nosipho Cele, Nagaraju Kerru, Lalitha Gummidi, Ebenezer Oluwakemi, Parvesh Singh   +5 more
semanticscholar   +1 more source

Tethered Indoxyl-Glucuronides for Enzymatically Triggered Cross-Linking

Molecules, 2023
Indoxyl-glucuronides, upon treatment with β-glucuronidase under physiological conditions, are well known to afford the corresponding indigoid dye via oxidative dimerization.
Juno Son, Zhiyuan Wu, Jinghuai Dou, Hikaru Fujita, Phuong-Lien Doan Cao, Qihui Liu, Jonathan S. Lindsey   +6 more
doaj   +1 more source

Intestinal bacterial β-glucuronidase as a possible predictive biomarker of irinotecan-induced diarrhea severity.

Pharmacology and Therapeutics, 2019
Irinotecan is an anticancer drug with a broad spectrum of activity, characterized by multistep and complex pharmacology. Regardless of its schedule of administration, neutropenia and delayed-type diarrhea are the most common side effects.
A. Chamseddine, M. Ducreux, J. Armand, X. Paoletti, T. Satar, A. Paci, O. Mir   +6 more
semanticscholar   +1 more source