Results 11 to 20 of about 2,563,124 (253)

Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis.

Fertility and Sterility, 2023
OBJECTIVE To explore the role of gut dysbiosis-derived β-glucuronidase (GUSB) in the development of endometriosis (EMs). DESIGN 16S rRNA sequencing of stool samples from women with (n = 35) or without (n = 30) endometriosis and from a mouse model was ...
Yajing Wei, Hao Tan, Ruyu Yang, Fan Yang, Duo Liu, Biqi Huang, Linglong Ouyang, Shuntian Lei, Zehai Wang, Shaoru Jiang, Heng Cai, Xiaofei Xie, S. Yao, Yanchun Liang   +13 more
semanticscholar   +3 more sources

Inhibition Properties of Arylsulfatase and β-Glucuronidase by Hydrogen Peroxide, Hypochlorite, and Peracetic Acid. [PDF]

ACS Omega, 2021
Arylsulfatase and β-glucuronidase are two important enzymes in humans, which play an important role in the dynamic equilibrium of steroidal estrogens.
Zhong SS, Zhang J, Liu ZH, Dang Z, Liu Y.   +4 more
europepmc   +3 more sources

Natural Flavonoids from Licorice as Potent Inhibitors of β-Glucuronidase Elucidated Through Computational Studies. [PDF]

Molecules
Gut bacterial β-glucuronidase is an important molecular target in several therapeutic applications. β-glucuronidase inhibitors can effectively alleviate gastrointestinal toxicity caused by certain drugs.
Liu J, Xue Y, Yan H, Zhou J, Long X, Tang Y.   +5 more
europepmc   +2 more sources

Molecular Insights Into β-Glucuronidase Inhibition by Alhagi Graecorum Flavonoids: A Computational and Experimental Approach. [PDF]

ChemistryOpen
In this study, we aimed to investigate the inhibitory mechanisms of β‐glucuronidase by flavonoids derived from Alhagi graecorum through both experimental and computational approaches.
Kamel EM, Maodaa S, Al-Shaebi EM, Mokhtar Lamsabhi A.   +3 more
europepmc   +2 more sources

Agrobacterium-Mediated Stable Transformation of Medicinal Plant Andrographis paniculata Callus Expressing β-glucuronidase (GUS) Gene

Indonesian Journal of Biotechnology, 2013
This study was carried out to establish a stable genetic transformation in callus culture of Andrographispaniculata mediated by Agrobacterium tumefaciens. The leaf disks of A. paniculata were infected with A.
Erly Marwani, Agustina Tangapo, Fenny Martha Dwivany   +2 more
doaj   +2 more sources

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors [PDF]

Molecules, 2014
Phenoxyacetohydrazide Schiff base analogs 1–28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 µM), 5 (IC50 = 9.47 ± 0.16 µM), 7 (IC50 = 14.7 ± 0.19 µM), 8 (IC50 = 15.4 ± 1.56 µM),
Waqas Jamil, Shagufta Perveen, Syed Adnan Ali Shah, Muhammad Taha, Nor Hadiani Ismail, Shahnaz Perveen, Nida Ambreen, Khalid M. Khan, Muhammad I. Choudhary   +8 more
doaj   +2 more sources

Continuous Spectrophotometric Assay for β-Glucuronidase

BioTechniques, 2001
A continuous spectrophotometric assay has been developed for detecting β-glucuronidase activity. In the assay, Para-nitrophenyl β-d-glucuronide is cleaved to yield a chromophoric product. With the commercial E.
Sanjukta Aich, Louis T.J. Delbaere, Ridong Chen   +2 more
doaj   +2 more sources

β-Glucuronidase-Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool. [PDF]

Adv Sci (Weinh)
Irinotecan (CPT11)‐induced diarrhea affects 80–90% of cancer patients due to β‐glucuronidase (GUS) converting 7‐ethyl‐10‐hydroxycamptothecin glucuronide (SN38G) to 7‐ethyl‐10‐hydroxycamptothecin (SN38).
Yue B, Gao R, Zhao L, Liu D, Lv C, Wang Z, Ai F, Zhang B, Yu Z, Geng X, Wang H, Wang K, Chen K, Liu C, Wang Z, Dou W.   +15 more
europepmc   +2 more sources

Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception

ACS Central Science, 2018
Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial GUS have been shown to alleviate these side effects.
Samuel J. Pellock, Benjamin C. Creekmore, William G. Walton, Naimee Mehta, Kristen A. Biernat, Andrew P. Cesmat, Yamuna Ariyarathna, Zachary D. Dunn, Bo Li, Jian Jin, Lindsey I. James, Matthew R. Redinbo   +11 more
doaj   +2 more sources

Production and Characterization of the Beneficial β-glucuronidase Inhibitor from non pathogenic wild yeast, Candida oleophila WP5-19-1, and its effects on gut microbes

한국균학회지, 2022
We aimed to produce a potent β-glucuronidase inhibitor from wild yeast that could inactivate toxic substances in the colon. Culture supernatants and cell-free extracts of non-pathogenic wild yeasts were prepared and their β-glucuronidase inhibitory ...
Seon-Jeong Park, Jong-Soo Lee
doaj   +1 more source