Assessment of gut microbial β-glucuronidase and β-glucosidase activity in women with polycystic ovary syndrome. [PDF]
Sci Rep, 2023 PCOS is a prevalent endocrine disorder among women of reproductive age, characterized by hormonal imbalances and metabolic disturbances. This study explores the correlation between gut microbial β-glucuronidase and β-glucosidase and PCOS, focusing on ...
Patel J +4 more
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The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer. [PDF]
Front Cell Dev Biol, 2021 Over the past decade, the gut microbiota has received considerable attention for its interactions with the host. Microbial β-glucuronidase generated by this community has hence aroused concern for its biotransformation activity to a wide range of ...
Sui Y, Wu J, Chen J.
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Fecal β-glucuronidase activity differs between hematopoietic cell and kidney transplantation and a possible mechanism for disparate dose requirements. [PDF]
Gut Microbes, 2022 The intestinal microbiota produces β-glucuronidase that plays an essential role in the metabolism of the immunosuppressant mycophenolate mofetil (MMF). This drug is commonly used in organ and hematopoietic cell transplantation (HCT), with variations in ...
Khan MH +7 more
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Inhibitory Activity of Bioactive Phloroglucinols from the Rhizomes of Dryopteris crassirhizoma on Escherichia coli β-Glucuronidase: Kinetic Analysis and Molecular Docking Studies [PDF]
Metabolites, 2022 Phloroglucinols—one of the major secondary metabolites in Dryopteris crassirhizoma—exhibit various pharmacological effects, such as antiviral, antioxidant, and antidiabetic activities. This study evaluated 30 phloroglucinols isolated from the rhizomes of
Phong NV +4 more
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Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. [PDF]
Commun Biol, 2021 Irinotecan inhibits cell proliferation and thus is used for the primary treatment of colorectal cancer. Metabolism of irinotecan involves incorporation of β-glucuronic acid to facilitate excretion. During transit of the glucuronidated product through the
Lin HY +13 more
europepmc +2 more sources
Predicting drug-metagenome interactions: Variation in the microbial β-glucuronidase level in the human gut metagenomes. [PDF]
PLoS One, 2021 Characterizing the gut microbiota in terms of their capacity to interfere with drug metabolism is necessary to achieve drug efficacy and safety. Although examples of drug-microbiome interactions are well-documented, little has been reported about a ...
Elmassry MM, Kim S, Busby B.
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Activity guided discovery of dual inhibitors of α-glucosidase and β-glucuronidase from the leaves of <i>Millettia pachycarpa</i> Benth. [PDF]
J Enzyme Inhib Med ChemType 2 diabetes mellitus (T2DM) and cancers are two globally prevalent diseases which can increase the incidence of each other. Intestinal α-glucosidase and β-glucuronidase are key targets for glycaemic control and chemotherapy detoxification ...
He Y +12 more
europepmc +2 more sources
Synthesis of 2-Aminopyrimidine Derivatives and Their Evaluation as β-Glucuronidase Inhibitors: In Vitro and In Silico Studies. [PDF]
Molecules, 2022 Currently the discovery and development of potent β-glucuronidase inhibitors is an active area of research due to the observation that increased activity of this enzyme is associated with many pathological conditions, such as colon cancer, renal diseases,
Iqbal S +7 more
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Incomplete Hydrolysis of Curcumin Conjugates by β-Glucuronidase: Detection of Complex Conjugates in Plasma. [PDF]
Mol Nutr Food Res, 2020 Scope The diphenol curcumin from turmeric is rapidly metabolized into phase II conjugates following oral administration, resulting in negligible plasma concentration of the free compound which is considered the bioactive form.
Luis PB +3 more
europepmc +2 more sources
Pharmacological hypothesis: A recombinant probiotic for taming bacterial β-glucuronidase in drug-induced enteropathy. [PDF]
Pharmacol Res Perspect, 2022 Advances in pharmacomicrobiomics have shed light on the pathophysiology of drug‐induced enteropathy associated with the therapeutic use of certain non‐steroidal anti‐inflammatory drugs, anticancer chemotherapies and immunosuppressants.
Jardou M +4 more
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