β-Hairpin-Based Peptide Hydrogels: The Case of MAX1 [PDF]
GelsThis review explores the advancements and applications of β-hairpin peptide hydrogels, starting from the paradigmatic case of MAX1 and its highly versatile analogue MAX8.
Mariantonietta Pizzella +6 more
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Synthetic antibacterial discovery of symbah-1, a macrocyclic β-hairpin peptide antibiotic [PDF]
iScience, 2022 Summary: The rapid development and spread of antibiotic resistance necessitate the development of novel strategies for antibiotic discovery. Symbah-1, a synthetic peptide antibiotic, was identified in a high-throughput antibacterial screen of random ...
Justin R. Randall +7 more
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Chlamydia plasmid-encoded protein Pgp2 is a replication initiator with a unique β-hairpin necessary for iteron-binding and plasmid replication [PDF]
Infection and ImmunityThe virulence plasmid of the obligate intracellular bacterium Chlamydia encodes eight proteins. Among these, Pgp3 is crucial for pathogenicity, and Pgp4 functions as a transcriptional regulator of both plasmid and chromosomal genes.
Danny Wan +3 more
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Dimerization of the β-Hairpin Membrane-Active Cationic Antimicrobial Peptide Capitellacin from Marine Polychaeta: An NMR Structural and Thermodynamic Study [PDF]
BiomoleculesCapitellacin is the β-hairpin membrane-active cationic antimicrobial peptide from the marine polychaeta Capitella teleta. Capitellacin exhibits antibacterial activity, including against drug-resistant strains.
Pavel A. Mironov +7 more
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Diagonal Interactions between Glutamate and Arginine Analogs with Varying Side-Chain Lengths in a β-Hairpin [PDF]
Molecules, 2023 Cross-strand interactions are important for the stability of β-sheet structures. Accordingly, cross-strand diagonal interactions between glutamate and arginine analogs with varying side-chain lengths were studied in a series of β-hairpin peptides.
Nian-Zhi Li +5 more
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An Improved Turn Structure for Inducing β-Hairpin Formation in Peptides [PDF]
Angewandte Chemie - International Edition, 2021 James Nowick +2 more
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Major Factors for the Persistent Folding of Hybrid α, β, γ-Hybrid Peptides Into Hairpins
Frontiers in Chemistry, 2020 Factors responsible for the persistent adoption of hairpin conformations by hybrid oligopeptides, each having a central β/α dipeptide segment flanked by aromatic γ-amino acid (γAr) residues, are probed. Our recent studies revealed that tetrapeptide 1 and
Yulong Zhong +6 more
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Crystals, 2022 Myelin basic protein (MBP) is one of the key proteins in the development of multiple sclerosis (MS). However, very few intracellular MBP partners have been identified up to now.
Evgeniya V. Smirnova +4 more
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Marine Drugs, 2020 Endogenous antimicrobial peptides (AMPs) are evolutionary ancient molecular factors of innate immunity that play a key role in host defense. Among the most active and stable under physiological conditions AMPs are the peptides of animal origin that adopt
Pavel V. Panteleev +7 more
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Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B. [PDF]
PLoS ONE, 2014 Nucleophosmin (NPM1) is an abundant, nucleolar tumor antigen with important roles in cell proliferation and putative contributions to oncogenesis. Wild-type NPM1 forms pentameric oligomers through interactions at the amino-terminal core domain.
Wei D Duan-Porter +4 more
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