Results 21 to 30 of about 1,046,387 (249)
Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium. [PDF]
PLoS ONE, 2016 FlgJ is a glycoside hydrolase (GH) enzyme belonging to the Carbohydrate Active enZyme (CAZy) family GH73. It facilitates passage of the bacterial flagellum through the peptidoglycan (PG) layer by cleaving the β-1,4 glycosidic bond between N ...
Patryk Zaloba +3 more
doaj +1 more source
The 5' spreading of small RNAs in Dictyostelium discoideum depends on the RNA-dependent RNA polymerase RrpC and on the dicer-related nuclease DrnB. [PDF]
PLoS ONE, 2013 RNA interference (RNAi) is a gene-regulatory mechanism in eukarya that is based on the presence of double stranded RNA and that can act on both, the transcription or post-transcriptional level.
Stephan Wiegand, Christian Hammann
doaj +1 more source
β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation
Frontiers in Cell and Developmental Biology, 2021 Amyloid diseases are degenerative pathologies, highly prevalent today because they are closely related to aging, that have in common the erroneous folding of intrinsically disordered proteins (IDPs) which aggregate and lead to cell death. Type 2 Diabetes
Jacopo Lesma +13 more
doaj +1 more source
Design of Stable β‑Hairpin Mimetics through Backbone Disulfide Bonds
, 2016 The synthesis and utilization of novel thiostatines (β-SH-substituted γ-amino acids) in the design of backbone-disulfide-stabilized β-hairpin mimetics, solution conformations of hybrid β-hairpins and Cys-disulfide-stabilized α-peptide analogue, their ...
Sachitanand M. Mali (1688140) +3 more
core +2 more sources
Evolutionary pathways of repeat protein topology in bacterial outer membrane proteins
eLife, 2018 Outer membrane proteins (OMPs) are the proteins in the surface of Gram-negative bacteria. These proteins have diverse functions but a single topology: the β-barrel.
Meghan Whitney Franklin +5 more
doaj +1 more source
Crystal Structure of Human Herpesvirus 6B Tegument Protein U14. [PDF]
PLoS Pathogens, 2016 The tegument protein U14 of human herpesvirus 6B (HHV-6B) constitutes the viral virion structure and is essential for viral growth. To define the characteristics and functions of U14, we determined the crystal structure of the N-terminal domain of HHV-6B
Bochao Wang +8 more
doaj +1 more source
eLife, 2022 The two-domain protein RfaH, a paralog of the universally conserved NusG/Spt5 transcription factors, is regulated by autoinhibition coupled to the reversible conformational switch of its 60-residue C-terminal Kyrpides, Ouzounis, Woese (KOW) domain ...
Philipp K Zuber +5 more
doaj +1 more source
, 2016 The temperature dependence of the 1H chemical shifts of six designed peptides previously shown to adopt β-hairpin structures in aqueous solution has been analyzed in terms of two-state (β-hairpin ⇆ coil) equilibrium.
Jorge Santoro (478257) +3 more
core +1 more source
Structure of the NheA component of the Nhe toxin from Bacillus cereus: implications for function.
PLoS ONE, 2013 The structure of NheA, a component of the Bacillus cereus Nhe tripartite toxin, has been solved at 2.05 Å resolution using selenomethionine multiple-wavelength anomalous dispersion (MAD).
Magdah Ganash +5 more
doaj +1 more source
β-Turn and β-Hairpin Mimicry with Tetrasubstituted Alkenes
, 2016 Synthesis and conformational analysis are reported for molecules containing the trans-5-amino-3,4-dimethylpent-3-enoic acid residue (ADPA, 1).
Gui-Bai Liang (1601764) +1 more
core +1 more source