Results 151 to 160 of about 1,046,387 (249)

Visualization of Self-Assembly and Hydration of a β-Hairpin through Integrated Small and Wide-Angle Neutron Scattering. [PDF]

Biomacromolecules, 2023
Laurent H, Hughes MDG, Walko M, Brockwell DJ, Mahmoudi N, Youngs TGA, Headen TF, Dougan L.   +7 more
europepmc   +1 more source

Designed β-hairpin switches for controllable mechanical properties

Nature achieves extraordinary mechanical performance by precisely regulating β-structure formation in proteins such as fibroin, elastin, and resilin. Replicating this level of structural control remains a major challenge in protein engineering.
Timo Laakko, Navneet Dwivedi, Pezhman Mohammadi, Sofia Julin, Cajsa Malm, Anna Borisova, Marc Baldus, Robert Pylkkänen, Gabriela Wojtan, Piotr Batys, Mohammadi, Pezhman; id_orcid, Dwivedi, Navneet, Pylkkänen, Robert; id_orcid, Wojtan, Gabriela, Baldus, Marc, Batys, Piotr, Julin, Sofia; id_orcid, Malm, Cajsa, Borisova, Anna; id_orcid, Laakko, Timo; id_orcid   +19 more
core   +1 more source

Tunable CH/π Interactions within a Tryptophan Zipper Motif to Stabilize the Fold of Long β-Hairpin Peptides. [PDF]

ACS Chem Biol, 2023
Richaud AD, Mandal S, Das A, Roche SP.
europepmc   +1 more source

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Conformational features and interaction mechanisms of V_H H antibodies with β-hairpin CDR3: A case of Nb8-HigB2 interaction. [PDF]

Protein Sci, 2023
Yamamoto K, Nagatoishi S, Matsunaga R, Nakakido M, Kuroda D, Tsumoto K.   +5 more
europepmc   +1 more source

β-Hairpin Antimicrobial Peptides: Class Diversity and Sequence Analysis. [PDF]

ACS Infect Dis
Ramtel R, Gu R, Abdulkareem MA, Randall JR.   +3 more
europepmc   +1 more source

Effects of chirality and side chain length in C_α,α-dialkylated residues on β-hairpin peptide folded structure and stability. [PDF]

Org Biomol Chem, 2023
Heath SL, Horne WS, Lengyel GA.
europepmc   +1 more source

Consequences of Peptide Macrocyclization Revealed by Virus-Inspired β-Hairpin Mimetics. [PDF]

ACS Chem Biol
Bula AL, Bobrovs R, Arsenyan P, Pantelejevs T.   +3 more
europepmc   +1 more source

Stapled β-Hairpin Antimicrobial Peptides with Improved Stability and Activity against Drug-Resistant Gram-Negative Bacteria. [PDF]

J Med Chem, 2023
Selvarajan V, Tram NDT, Xu J, Ngen STY, Koh JJ, Teo JWP, Yuen TY, Ee PLR.   +7 more
europepmc   +1 more source

Exploring the temperature dependence of β-hairpin peptide self-assembly. [PDF]

Faraday Discuss
Samdin TD, Wang X, Fichman G, Schneider JP.   +3 more
europepmc   +1 more source