Results 21 to 30 of about 1,516,213 (305)

A Conformationally Stable Acyclic β-Hairpin Scaffold Tolerating the Incorporation of Poorly β-Sheet-Prone Amino Acids. [PDF]

Chembiochem, 2022
Stanojlovic V, Müller A, Moazzam A, Hinterholzer A, Ożga K, Berlicki Ł, Schubert M, Cabrele C.   +7 more
europepmc   +2 more sources

Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
Cody L. Hoop, Hsiang-Kai Lin, Karunakar Kar, Gábor Magyarfalvi, Jonathan M. Lamley, Jennifer C. Boatz, Abhishek Mandal, Józef R. Lewandowski, Ronald Wetzel, Patrick C.A. van der Wel   +9 more
openalex   +2 more sources

Effects of Familial Alzheimer's Disease Mutations on the Assembly of a β-Hairpin Peptide Derived from Aβ_16-36. [PDF]

Biochemistry, 2022
McKnelly KJ, Kreutzer AG, Howitz WJ, Haduong K, Yoo S, Hart C, Nowick JS.   +6 more
europepmc   +3 more sources

Major Factors for the Persistent Folding of Hybrid α, β, γ-Hybrid Peptides Into Hairpins

Frontiers in Chemistry, 2020
Factors responsible for the persistent adoption of hairpin conformations by hybrid oligopeptides, each having a central β/α dipeptide segment flanked by aromatic γ-amino acid (γAr) residues, are probed. Our recent studies revealed that tetrapeptide 1 and
Yulong Zhong, Quan Tang, Daniel P. Miller, Eva Zurek, Rui Liu, Zhong-Lin Lu, Bing Gong   +6 more
doaj   +1 more source

De novo design of a pH-triggered self-assembled β-hairpin nanopeptide with the dual biological functions for antibacterial and entrapment

Journal of Nanobiotechnology, 2021
Background Acid-tolerant enteric pathogens can evade small intestinal acid barriers, colonize and infect the intestinal tract. However, broad-spectrum antibiotics are not the best therapeutic strategy because of the disruption of intestinal flora caused ...
Qiuke Li, Jinze Li, Weikang Yu, Zhihua Wang, Jiawei Li, Xingjun Feng, Jiajun Wang, A. Shan   +7 more
semanticscholar   +1 more source

Deconvolution of the MBP-Bri2 Interaction by a Yeast Two Hybrid System and Synergy of the AlphaFold2 and High Ambiguity Driven Protein-Protein Docking

Crystals, 2022
Myelin basic protein (MBP) is one of the key proteins in the development of multiple sclerosis (MS). However, very few intracellular MBP partners have been identified up to now.
Evgeniya V. Smirnova, Tatiana V. Rakitina, George A. Saratov, Anna A. Kudriaeva, Alexey A. Belogurov   +4 more
doaj   +1 more source

Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B. [PDF]

PLoS ONE, 2014
Nucleophosmin (NPM1) is an abundant, nucleolar tumor antigen with important roles in cell proliferation and putative contributions to oncogenesis. Wild-type NPM1 forms pentameric oligomers through interactions at the amino-terminal core domain.
Wei D Duan-Porter, Virgil L Woods, Kimberly D Maurer, Sheng Li, Antony Rosen   +4 more
doaj   +1 more source

Secondary-Structure Design of Proteins by a Backbone Torsion Energy [PDF]

, 2005
We propose a new backbone-torsion-energy term in the force field for protein systems. This torsion-energy term is represented by a double Fourier series in two variables, the backbone dihedral angles phi and psi.
Berendsen H. J. C., Blanco F. J., Cornell W. D., Duan Y., Garcia A. E., Honda S., Iwaoka M., Jorgensen W. L., Kabsch W., Kaminski G. A., Kamiya N., Kirkpatrick S., Kobayashi N., Kraulis P. J., MacKerell A. D., MacKerrell A. D., Merritt E. A., Mitsutake A., Némethy G., Osterhout J. J., Qiu D., Ramachandran G. N., Sakae Y., Sakae Y., Sakae Y., Shoemaker K. R., Simmerling C., Still W. C., Wang J., Yoda T., Yoda T.   +30 more
core   +2 more sources

Structural relationships in the lysozyme superfamily: significant evidence for glycoside hydrolase signature motifs. [PDF]

PLoS ONE, 2010
BackgroundChitin is a polysaccharide that forms the hard, outer shell of arthropods and the cell walls of fungi and some algae. Peptidoglycan is a polymer of sugars and amino acids constituting the cell walls of most bacteria.
Alexandre Wohlkönig, Joëlle Huet, Yvan Looze, René Wintjens   +3 more
doaj   +1 more source

Tethering-facilitated DNA ‘opening’ and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein

bioRxiv, 2020
XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix-destabilizing/distorting DNA lesions by selectively ‘opening’ these sites while rapidly diffusing along undamaged DNA.
D. Paul, Hong Mu, Amirrasoul Tavakoli, Qing Dai, Xuejing Chen, S. Chakraborty, Chuan He, A. Ansari, S. Broyde, Jung-Hyun Min   +9 more
semanticscholar   +1 more source