Results 161 to 170 of about 899,318 (275)

Euglycemic Diabetic Ketoacidosis Mimicking an Acute Asthma Exacerbation in a Young Adult With New‐Onset Diabetes: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Euglycemic diabetic ketoacidosis can mimic acute asthma, including in previously undiagnosed diabetes and without SGLT‐2 inhibitor use. Carbohydrate restriction may precipitate life‐threatening ketoacidosis, particularly with insulin deficiency.
Faizan E Mustafa, Sarim Hassan Shahab, Basit Ali, Aleena Majeed, Fazal Habib, Muhammad Sajjad   +5 more
wiley   +1 more source

Modulation of Endoplasmic Reticulum Stress via CEBPB: A Potential Molecular Link to Therapeutic Action in Substance Use Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
We identified endoplasmic reticulum (ER) stress modulation as a convergent transcription signature across fentanyl and multiple substance use disorder (SUD)‐relevant treatments. Key ER stress genes, including TRIB3, XBP1, and DDIT3, were downregulated, while CEBPB emerged as a shared upstream regulator linked to ER stress–related proteins.
Cheng Zhang, Hu Li, Ming‐Fen Ho
wiley   +1 more source

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

RagC senses β-hydroxybutyrate abundancy to suppress mTORC1. [PDF]

Protein Cell
Wang G, Hou Q, Zhang Y, Duan Q, Gao J, Wang J, Qiao J, Zheng Y, Lei X, Liu G, Lei L, Meng T, Yang X, Yao J, Li X, Deng L.   +15 more
europepmc   +1 more source

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina   +4 more
wiley   +1 more source

Inflammatory and catabolic activity mediate the association of plasma β-hydroxybutyrate and mortality in heart failure. [PDF]

ESC Heart Fail
Palm CL, van Essen BJ, Baumhove L, Alnuwaysir RIS, Connelly MA, Petersmann A, Hoegl A, Madsen CT, Refgaard JC, Conde-Knape K, Barascuk-Michaelsen N, Lang C, Voors AA, Westenbrink BD.   +13 more
europepmc   +1 more source

Management of ketogenic diet therapy in patients with ileostomy: A report of 2 cases

Nutrition in Clinical Practice, Volume 41, Issue 5, Page 1514-1520, October 2026.
Abstract This case series explores the feasibility and clinical considerations of implementing the ketogenic diet therapy (KDT) for epilepsy management in patients with ileostomies. Two pediatric patients with medication‐resistant epilepsy and ileostomies continued KDT under clinical supervision.
Braden J. Baker, Abigail E. Olbina, Marissa A. Godfrey, Annie E. Graber, Taylor N. Parrish, Sarah Isis R. Delima   +5 more
wiley   +1 more source

Transcriptomic and metabolomic analyses reveal that lobeglitazone ameliorates hepatic steatosis in rats concurrent with regulation of mitochondrial pyruvate metabolism

British Journal of Pharmacology, Volume 183, Issue 19, Page 5935-5952, October 2026.
Background and Purpose Lobeglitazone is a thiazolidinedione and PPARγ agonist that improves metabolic parameters and hepatic steatosis, but its mechanisms are not fully understood. This study investigated the effects of lobeglitazone on hepatic transcriptomic and metabolic profiles in a rat model of obesity and Type 2 diabetes mellitus.
Hyekyung Yang, Su Young Son, Youngmi Song, Hyewon Choi, In‐Gu Do, Choong Hwan Lee, Cheol‐Young Park   +6 more
wiley   +1 more source

Circulating β-Hydroxybutyrate in Glycemic Progression and Diabetic Cardiomyopathy: Adaptive Signal or Maladaptive Substrate? [PDF]

Int J Mol Sci
Kim SR, Lee BW.
europepmc   +1 more source

β-Hydroxybutyrate Promotes Cancer Cell Paclitaxel Resistance by Binding α/βIII-Tubulin Heterodimer and Inhibiting Microtubule Hyperpolymerization

Paclitaxel resistance drives tumor relapse and undermines the effectiveness of subsequent targeted and immune treatments. Understanding these resistance mechanisms is essential to identify new therapeutic vulnerabilities and restore drug sensitivity ...
Tao Chang, Changliang Shan, Jun Fan, Xu-Jun Zhou, Qi Feng, Yue He, Yifan Zhang, Hao Wang, Lvfen Gao, Xu-An Chen, Yong Sun, Le Li, Lei Peng, Meng Wang, xiaoyin chen, Hao Sheng   +15 more
core   +1 more source