Results 141 to 150 of about 764,478 (294)

Lithium Diisopropylamide‐Mediated Ring‐Opening of Tetrahydrofuran in the Synthesis of Polyhydroxylated Indolizidines

European Journal of Organic Chemistry, EarlyView.
Chiral tri‐ and pentahydroxy spirocyclopentane‐indolizidines were synthesized using lithium diisopropylamide “LDA” promoted diallylation and tetrahydrofuran “THF” ring‐opening in a one‐pot procedure as a key step. The sequence leading to the targeted hydroxy‐spiroindolizidines was achieved by cis‐dihydroxylation followed by reduction of the enamine and
Paula Fraňová, Peter Šafář, Marchalín Štefan, Petra Pažitná, Ivana Žídeková, Ján Moncol, Adam Daïch   +6 more
wiley   +1 more source

β-lactam-induced MRSA biofilm

, 2014
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital- and community-associated infections. The formation of adherent clusters of cells known as biofilms is an important virulence factor in MRSA pathogenesis.
Piotrowski, Brian O., Callahan, Mary T., Roberts, Afsoon D., Keiser, John F., Ng, Mandy, Epstein, Samuel B., Kaplan, Jeffrey B., Simon, Gary L.   +7 more
core  

Alkyl Arylacetates in Cascade Reactions with 2‐Cyanobenzaldehydes for the Synthesis of 3‐Substituted Isoindolinones

European Journal of Organic Chemistry, EarlyView.
Effective synthesis of 3‐substituted isoindolinones is possible through novel cascade reactions of alkyl arylacetates with 2‐cyanobenzaldehydes under mild, basic conditions. Herein we report the use of alkyl arylacetates as pro‐nucleophiles in cascade reactions with 2‐cyanobenzaldehydes leading to the formation of novel 3‐substituted isoindolinones, a ...
Antonia Di Mola, Prabaharan Thiruvengetam, Alessandra Forlenza, Armin R. Ofial, Antonio Massa   +4 more
wiley   +1 more source

Partial purification and properties of the α-ketoglutarate-linked ring-expansion enzyme of β-lactam biosynthesis of Cephalosporium acremonium [PDF]

FEMS Microbiology Letters, 1983
Jutta Kupka, Yong-Qiang Shen, Saul Wolfe, Arnold L. Demain   +3 more
openaire   +1 more source

Validated RP‐HPLC–UV Method for the Quantitative Analysis and Stability Evaluation of Amoxicillin in Paediatric Gummy Tablets

ELECTROPHORESIS, EarlyView.
A validated RP‐HPLC–UV method was successfully applied for amoxicillin determination in gummy tablets. The method is useful for an accurate amoxicillin content determination in paediatric gummies and was applied to study the stability profile of the drug, evaluated over 6 months under storage conditions.
Samuele Bonafè, Anna Imbriano, Cinzia Pagano, Anna Migni, Elisa Bianconi, Laura Mercolini, Luana Perioli, Roccaldo Sardella   +7 more
wiley   +1 more source

Sodium deoxycholate synergistically enhances the antimicrobial activity of β-lactam antibiotics againstβ-lactamase-producing Staphylococcus aureus [PDF]

, 2012
Background β-lactamase-producing Staphylococcus aureus synthesizes a β-lactamase which decomposes the β-lactam ring, and consequently almost all β-lactam antibiotics are inactivated by the enzyme. The appearance of β-lactamase-producing bacterial strains
Yamada, Akira, Yoshida, Sayuri, Yaegashi, Asaka, Fujii, Yuichi, Hirano, Kano, Nozawa, Koohei, Tanaka, Satomi, Yamaki, Fumiko, Horie, Hitoshi   +8 more
core  

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

In Vitro Characterization of Technological and Health‐Promoting Properties of Enterocin Producing Lactic Acid Bacteria From Camel Milk and Its Suitability as a Dairy Starter

Food Chemistry International, EarlyView.
Enterocin‐producing Enterococcus faecium RSCUDR7 from camel milk exhibited strong probiotic and antimicrobial properties, along with stability in skim milk. Its suitability as a safe and effective dairy starter highlights its potential for developing functional probiotic dairy products.
Rahul Singhal, Kamalesh Kumar Meena, Manvik Joshi, Lokesh Gupta, Sunil Meena   +4 more
wiley   +1 more source

Tunicamycin and β-Lactams with Five Membered Ring Structures Have Stronger Synergistic Effects Against Gram-Positive Bacteria

Zoonoses
The prevalence of antimicrobial resistance is increasing among gram-positive bacteria, particularly the resistance of methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics. Checkerboard minimum inhibitory concentration (MIC) assays,
Xueyangyang Bai, Jinjing Xue, Fei He, Xiaotong Yang, Houru Liu, Kuan Gu, Qianghua Lv, Yonglin Zhou   +7 more
doaj   +1 more source

Characterisation of a novel plasmid-mediated β-lactamase and its contribution to β-lactam resistance inPseudomonas aeruginosa [PDF]

FEMS Microbiology Letters, 1983
I.N. Simpson, S.J. Plested, Miroslava J. Budin-Jones, Jeanette Lees, R.W. Hedges, G.A. Jacoby   +5 more
openaire   +1 more source