Results 141 to 150 of about 937,622 (274)

Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies

Chemistry – A European Journal, EarlyView.
Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms

, 2017
Bacterial biofilms show high tolerance towards antibiotics and are a significant problem in clinical settings where they are a primary cause of chronic infections.
Ardeshir Rineh (20121465), Saul Faust (6313958), Stuart Clarke (2390449), Raymond Allan (20215053), Odel Soren (8804567), Michael Kelso (19588105), Paul Stoodley (34108), Sanjita Brito-Mutunayagam (20218455), Rami Salib (20218458), Martin Feelisch (358503), Luanne Hall-Stoodley (588643), Nageshwar Rao Yepuri (20117190), Jeremy Webb (625757)   +12 more
core  

Tunicamycin and β-Lactams with Five Membered Ring Structures Have Stronger Synergistic Effects Against Gram-Positive Bacteria

Zoonoses
The prevalence of antimicrobial resistance is increasing among gram-positive bacteria, particularly the resistance of methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics. Checkerboard minimum inhibitory concentration (MIC) assays,
Xueyangyang Bai, Jinjing Xue, Fei He, Xiaotong Yang, Houru Liu, Kuan Gu, Qianghua Lv, Yonglin Zhou   +7 more
doaj   +1 more source

N‐Sulfonyl Azalevoglucosan: A Versatile Platform for the Synthesis of Polysubstituted Piperidines

Chemistry – A European Journal, EarlyView.
Gain by strain: The synthesis of a levoglucosan analog, in which the pyranose oxygen has been replaced by a nitrogen, allows navigation on the piperidine ring to iteratively install functional groups at C1, C2, C3, C4, and C6 positions using simple experimental protocols with minimal protecting group manipulation.
Dylan Yorga, Jérôme Marrot, Ana Poveda, Nicolas Auberger, Jesús Jiménez‐Barbero, Jérôme Désiré, Yves Blériot   +6 more
wiley   +1 more source

Designing a Triplet 2‐Formylphenylnitrene With Fast Tunneling Reactivity

Chemistry – A European Journal, EarlyView.
A 3‐CF3 substituent accelerates tunneling in triplet 2‐formylphenylnitrene, making its reactivity in cryogenic matrices too fast for conventional IR spectroscopic detection. Bringing this chemistry to low‐temperature solutions allows suppression of intrinsic nitrene dimerization through faster cyclization, which even outcompetes the 1,4‐H shift ...
Sofia Braz, Cláudio M. Nunes, Simon Schlosser, Peter R. Schreiner, Rui Fausto   +4 more
wiley   +1 more source

Table_2_Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM.DOCX

Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options.
Xue Gong (144222), Xinhui Li (349485), Jianmin Wang (59025), Longjin Liu (18106015), Wenzhang Long (18106009), Xiaoli Zhang (135098), Jie Li (15030), Yang Yang (45629), Jisheng Zhang (227247), Xushan Liang (18106012)   +9 more
core   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Table_1_Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM.DOCX

Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options.
Xue Gong (144222), Xinhui Li (349485), Jianmin Wang (59025), Longjin Liu (18106015), Wenzhang Long (18106009), Xiaoli Zhang (135098), Jie Li (15030), Yang Yang (45629), Jisheng Zhang (227247), Xushan Liang (18106012)   +9 more
core   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source