Results 121 to 130 of about 937,622 (274)

Intrinsic Class D β-Lactamases of Clostridium difficile

mBio, 2018
Clostridium difficile is the causative agent of the deadly C. difficile infection. Resistance of the pathogen to β-lactam antibiotics plays a major role in the development of the disease, but the mechanism of resistance is currently unknown.
Marta Toth, Nichole K. Stewart, Clyde Smith, Sergei B. Vakulenko   +3 more
doaj   +1 more source

Functional insights into Streptomyces isolates containing both clavulanic acid-like and carbapenem biosynthetic gene clusters

mSphere
β-Lactam antibiotics and β-lactamase inhibitor combinations are essential for combating antimicrobial resistance, with many β-lactams, including clavulanic acid (CA), themselves being products of specialized metabolic pathways in bacteria. CA is a potent
Kapil Tahlan, Arshad Ali Shaikh, Jingyu Liu, Kajal Gupta, Nader AbuSara, Santosh Kumar Srivastava, Adau Deng, Ayla Rouah, Madelyn Joan Swackhamer   +8 more
doaj   +1 more source

Interaction of β-lactam antibiotics with penicillin-binding proteins fromPseudomonas aeruginosa [PDF]

FEMS Microbiology Letters, 1982
Alfredo Rodriguez-Tebár, Fernando Rojo, Juan C. Montilla, David Vázquez   +3 more
openaire   +1 more source

Development of a new family of conformationally restricted peptides as potent nucleators of β-turns. Design, synthesis, structure, and biological evaluation of a β-lactam peptide analogue of melanostatin

, 2003
Novel enantiopure (i)-(β-lactam)-(Gly)-(i+3) peptide models, defined by the presence of a central α-alkyl-α-amino-β-lactam ring placed as the (i+1) residue, have been synthesized in a totally stereocontrolled way by α-alkylation of suitable N-[bis ...
Palomo, Claudio, Gago, Federico, Martin-Santamaria, Sonsoles, Fratila, Raluca M., Matute, Carlos, Linden, Anthony, Domercq, Maria, Benito, Ana M., Aizpurua, Jesús M., Miranda, José Ignacio   +9 more
core   +1 more source

Synthesis and enzyme-based evaluation of analogues L-tyrosine thiol carboxylic acid inhibitor of metallo-β-lactamase IMP-1

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The emergence of drug-resistant pathogenic bacteria is occurring due to the global overuse and misuse of β-lactam antibiotics. Infections caused by some bacteria which secrete metallo-β-lactamases (enzymes that inactivate β-lactam antibiotics) are ...
Omid Khalili Arjomandi, Mahboubeh Kavoosi, Hadi Adibi   +2 more
doaj   +1 more source

Increase in activity of β-lactam synthetases after growth ofCephalosporium acremoniumwith methionine or norleucine [PDF]

FEMS Microbiology Letters, 1980
Y. Sawada, T. Konomi, N.A. Solomon, A.L. Demain   +3 more
openaire   +1 more source

The synthesis and structural characterisation of novel 4- and 5- membered nitrogen heterocycles derived from azoacetates [PDF]

, 2009
Azo-drugs are among the earliest fully synthetic chemotherapeutic agents known (Prontosil 1935). However the synthesis and application of phenylazo compounds in the area of medicinal chemistry has largely been restricted to derivatives of primary ...
O'Halloran, Neil
core  

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Partial purification and properties of the α-ketoglutarate-linked ring-expansion enzyme of β-lactam biosynthesis of Cephalosporium acremonium [PDF]

FEMS Microbiology Letters, 1983
Jutta Kupka, Yong-Qiang Shen, Saul Wolfe, Arnold L. Demain   +3 more
openaire   +1 more source