Results 111 to 120 of about 764,478 (294)

OmpF channel permeability of quinolones and their comparison with β-lactams [PDF]

FEMS Microbiology Letters, 1992
Tetsuo Sawai, Akihito Yamaguchi, Akiko Saiki, Kazuki Hoshino   +3 more
openaire   +1 more source

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases

, 2019
Breakdown of β-lactam antibiotics by β-lactamases is one of the most common resistance mechanisms against these drugs. Here, we present a computationally efficient combined quantum mechanics/molecular mechanics simulation protocol for hydrolysis of the β-
Ewa I., Chudyk, Katharine, Hammond, Adrian, Mulholland, Viivi H. A., Hirvonen, Marc W. van der, Kamp, James, Spencer, Michael A. L., Limb   +6 more
core   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source

Synthesis and enzyme-based evaluation of analogues L-tyrosine thiol carboxylic acid inhibitor of metallo-β-lactamase IMP-1

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The emergence of drug-resistant pathogenic bacteria is occurring due to the global overuse and misuse of β-lactam antibiotics. Infections caused by some bacteria which secrete metallo-β-lactamases (enzymes that inactivate β-lactam antibiotics) are ...
Omid Khalili Arjomandi, Mahboubeh Kavoosi, Hadi Adibi   +2 more
doaj   +1 more source

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood, Sarah Bannister, Stephen Duffull, April Martinez, Sarath Ranganathan, Shivanthan Shanthikumar, Amanda Gwee   +6 more
wiley   +1 more source

Synthesis of Some Novel β-lactam Derivatives

, 1982
Department of Chemistry, Indian Institute of Technology, Kharagpur-721 302 One oxa-dethiacepham derivative containing one fused and one isolated β-lactam moieties has been synthesised utilizing the ketene-imine reaction and (2 +2) cycloaddifion of CSI ...
J. K. RAY, BASANTA G. CHATTERJEE, SITARAM SHARMA   +2 more
core   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Treatment of community-onset pneumonia in neutropenic cancer patients: β-lactam monotherapy versus combination antibiotic regimens

Pneumonia, 2019
Background Although β-lactam monotherapy may be sufficient in non-critically ill patients with community-acquired pneumonia, the value of combination antibiotic regimens in community-onset neutropenic pneumonia remains unclear.
Hyeri Seok, Jae-Hoon Ko, Kyong Ran Peck, Ji-Yeon Kim, Ji Hye Lee, Ga Eun Park, Sun Young Cho, Cheol-In Kang, Nam Yong Lee, Doo Ryeon Chung   +9 more
doaj   +1 more source

The enzymes of β-lactam biosynthesis.

, 2013
The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via ...
Gomez-Castellanos, JR, J. Ruben Gomez-Castellanos, Refaat B. Hamed, Hamed, RB, Christian Ducho, Ducho, C, Luc Henry, Michael A. McDonough, Schofield, CJ, McDonough, MA, Henry, L, Schofield, Christopher, Christopher J. Schofield   +12 more
core   +1 more source