Results 111 to 120 of about 937,622 (274)

OmpF channel permeability of quinolones and their comparison with β-lactams [PDF]

FEMS Microbiology Letters, 1992
Tetsuo Sawai, Akihito Yamaguchi, Akiko Saiki, Kazuki Hoshino   +3 more
openaire   +1 more source

Synthesis of β-Lactam Scaffolds for Ditopic Peptidomimetics

, 2007
Ring opening of α-substituted-α-methoxycarbonyl-N-nosylaziridines provides a practical access to enantiopure α,α‘-disubstituted β-lactam scaffolds, novel types of ditopic reverse turn surrogates.
Palomo, Claudio, Balentová, Eva, Oyarbide, Joseba, Fratila, Raluca M., Jimenez, Azucena, Aizpurua, Jesús M., Miranda, José Ignacio   +6 more
core   +1 more source

Effect of β-lactam antibiotics on the gut microbiota of term neonates

Annals of Clinical Microbiology and Antimicrobials
β-Lactam antibiotics are a class of antibiotics commonly used to treat bacterial infections. However, the effects of β-lactam antibiotics on term neonatal intestinal flora have not been fully elucidated. Hospitalized full-term newborns receiving β-lactam
Hongdan Gu, Enfu Tao, Yijia Fan, Gao Long, Xinyi Jia, Tianming Yuan, Lihua Chen, Xiaoli Shu, Wei Zheng, Mizu Jiang   +9 more
doaj   +1 more source

Hypericin enhances β-lactam antibiotics activity by inhibiting sarA expression in methicillin-resistant Staphylococcus aureus

Acta Pharmaceutica Sinica B, 2019
Bacteremia is a life-threating syndrome often caused by methicillin-resistant Staphylococcus aureus (MRSA). Thus, there is an urgent need to develop novel approaches to successfully treat this infection.
Genzhu Wang, Liang Li, Xiukun Wang, Xue Li, Youwen Zhang, Jie Yu, Jiandong Jiang, Xuefu You, Yan Q. Xiong   +8 more
doaj   +1 more source

Outer membrane vesicles from β-lactam-resistant Escherichia coli enable the survival of β-lactam-susceptible E. coli in the presence of β-lactam antibiotics

, 2018
Outer membrane vesicles (OMVs) containing various bacterial compounds are released from mainly gram-negative bacteria. Secreted OMVs play important roles in the ability of a bacterium to defend itself, and thus contribute to the survival of bacteria in a
Jong-Su Seo, Suk-Kyung Lim, Se Pyeong Im, Jaesung Kim, Jong-Hwan Kim, Tae Sung Jung, Jung Seok Lee, Jae Wook Jung, Gwang Joong Kim, Seong Bin Park, Jong-Wook Song, Young Ju Lee, Si Won Kim, Hyun Suk Jung, Tae Won Gong, Jassy Mary S. Lazarte   +15 more
core   +1 more source

Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae.

PLoS Pathogens
Neisseria gonorrhoeae exhibits alarming antibiotic resistance trends and poses a significant challenge in therapeutic management. This study aimed to explore the association of penA alleles with penicillin-binding protein (PBP) occupancy patterns and ...
Silvia López-Argüello, Eva Alcoceba, Paula Ordóñez, Biel Taltavull, Gabriel Cabot, Maria Antonia Gomis-Font, Antonio Oliver, Bartolome Moya   +7 more
doaj   +1 more source

β-Lactam Antibiotics Enhance the Pathogenicity of Methicillin-Resistant Staphylococcus aureus via SarA-Controlled Lipoprotein-Like Cluster Expression

mBio, 2019
Methicillin-resistant Staphylococcus aureus (MRSA) resists nearly all β-lactam antibiotics that have a bactericidal activity. However, whether the empirically used β-lactams enhance MRSA pathogenicity in vivo remains unclear.
Weilong Shang, Yifan Rao, Ying Zheng, Yi Yang, Qiwen Hu, Zhen Hu, Jizhen Yuan, Huagang Peng, Kun Xiong, Li Tan, Shu Li, Junmin Zhu, Ming Li, Xiaomei Hu, Xuhu Mao, Xiancai Rao   +15 more
doaj   +1 more source

An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases [PDF]

, 2019
Breakdown of β-lactam antibiotics by β-lactamases is one of the most common resistance mechanisms against these drugs. Here, we present a computationally efficient combined quantum mechanics/molecular mechanics simulation protocol for hydrolysis of the β-
Ewa I., Chudyk, Katharine, Hammond, Adrian, Mulholland, Viivi H. A., Hirvonen, Marc W. van der, Kamp, James, Spencer, Michael A. L., Limb   +6 more
core   +2 more sources

A β-Lactam-Based Stereoselective Access to β,γ-Dihydroxy α-Amino Acid-Derived Peptides with Either α,β-Like or Unlike Configurations

, 2016
A concise access to α,β-dihydroxy α-amino acid-derived N-carboxy anhydrides (NCAs) with either like or unlike relative configuration is described. The key steps of the synthetic route are the preparation of the nonracemic 4-alkenyl β-lactams, through ...
Claudio Palomo (1699948), Mikel Oiarbide (1699942), Anthony Linden (1673590), Aitor Landa (2130454), Aitor Esnal (3027681)   +4 more
core   +2 more sources

Characterization of BAS-1, a novel class A β-lactamase encoded in Bacteroides thetaiotaomicron

Antimicrobial Agents and Chemotherapy
We characterized a novel class A β-lactamase (BAS-1) in a pan-β-lactam-resistant Bacteroides thetaiotaomicron clinical isolate. Whole-genome sequencing identified blaBAS-1 within a mobile genetic element associated with IS4351.
María Aznar Fernández, María José Gómez Gómez, José Miguel Cisneros, José Antonio Lepe, José Manuel Ortiz de la Rosa   +4 more
doaj   +1 more source