Results 131 to 140 of about 764,478 (294)

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Data_Sheet_1_Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM.docx

Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options.
Xue Gong (144222), Xinhui Li (349485), Jianmin Wang (59025), Longjin Liu (18106015), Wenzhang Long (18106009), Xiaoli Zhang (135098), Jie Li (15030), Yang Yang (45629), Jisheng Zhang (227247), Xushan Liang (18106012)   +9 more
core   +1 more source

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source

Increase in activity of β-lactam synthetases after growth ofCephalosporium acremoniumwith methionine or norleucine [PDF]

FEMS Microbiology Letters, 1980
Y. Sawada, T. Konomi, N.A. Solomon, A.L. Demain   +3 more
openaire   +1 more source

Table_2_Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM.DOCX

Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options.
Xue Gong (144222), Xinhui Li (349485), Jianmin Wang (59025), Longjin Liu (18106015), Wenzhang Long (18106009), Xiaoli Zhang (135098), Jie Li (15030), Yang Yang (45629), Jisheng Zhang (227247), Xushan Liang (18106012)   +9 more
core   +1 more source

Design, synthesis and evaluation of β-lactam antigenic peptide hybrids; unusual opening of the β-lactam ring in acidic media

, 2010
β-Lactam peptides were envisioned as conformational constraints in antigenic peptides (APs). Three different β-lactam tripeptides of varying flexibility were prepared in solution and incorporated in place of the central part of the altered melanoma ...
Balentová, Eva, Emily E. Edwards, Quideau, Stéphane, Aizpurua, Jesus M., Marion Tarbe, Jesus M. Aizpurua, Edwards, Emily E., Tarbe, Marion, Azcune, Itxaso, Baker, Brian M., Miles, Kim M., Miles, John J., Itxaso Azcune, Sewell, Andrew K., Douat-Casassus, Céline, Stéphane Quideau, Eva Balentová, Céline Douat-Casassus, Priscilla Do, Andrew K. Sewell, Do, Priscilla, John J. Miles, Kim M. Miles, Brian M. Baker   +23 more
core   +1 more source

Antibacterial Activity of Heteropolytungstates Against Proteus mirabilis

European Journal of Inorganic Chemistry, EarlyView.
We investigated the in vitro antibacterial activity of several heteropolytungstates against P. mirabilis, a drug‐resistant pathogen. All tested polyanions inhibited bacterial growth, with the Preyssler–Pope–Jeannin polyanion P5W30 exhibiting the highest activity (MIC = 0.78 mg/mL).
Nour El Ghouch, Ahmad Asaad, Rana El Hajj, Sahar Khandan, Matthias S. Ullrich, Ulrich Kortz   +5 more
wiley   +1 more source

Table_1_Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM.DOCX

Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options.
Xue Gong (144222), Xinhui Li (349485), Jianmin Wang (59025), Longjin Liu (18106015), Wenzhang Long (18106009), Xiaoli Zhang (135098), Jie Li (15030), Yang Yang (45629), Jisheng Zhang (227247), Xushan Liang (18106012)   +9 more
core   +1 more source

The synthesis and structural characterisation of novel 4- and 5- membered nitrogen heterocycles derived from azoacetates [PDF]

, 2009
Azo-drugs are among the earliest fully synthetic chemotherapeutic agents known (Prontosil 1935). However the synthesis and application of phenylazo compounds in the area of medicinal chemistry has largely been restricted to derivatives of primary ...
O\u27Halloran, Neil, O'Halloran, Neil
core  

Total Synthesis and Immunosuppressive Activity of (−)-Pateamine A and Related Compounds:  Implementation of a β-Lactam-Based Macrocyclization

, 2016
The asymmetric synthesis of the potent immunosuppressive agent (−)-pateamine A isolated from the marine sponge Mycale sp. is described. A key strategy employed in the synthesis was a β-lactam-based macrocyclization to form the 19-membered dilactone ...
Daniel Romo (246583), Luo Sun (3005187), Robert M. Rzasa (1692925), Helene A. Shea (2705461), Kaapjoo Park (1638997), Joseph M. Langenhan (1708711), Jun O. Liu (203637), Alexander Akhiezer (3005190)   +7 more
core   +1 more source