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The Road to Avibactam: The First Clinically Useful Non-β-Lactam Working Somewhat Like a β-Lactam [PDF]

Future Medicinal Chemistry, 2016
Avibactam, which is the first non-β-lactam β-lactamase inhibitor to be introduced for clinical use, is a broad-spectrum serine β-lactamase inhibitor with activity against class A, class C, and, some, class D β-lactamases.
Jürgen Brem, Christopher Schofield, Marios Markoulides   +2 more
exaly   +2 more sources

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Synthesis of 4-aminoguaiazulene and its δ-lactam derivatives

Tetrahedron Letters, 2011
Abstract A method for nitrogen insertion into guaiazulene hydrocarbons is developed. A one-pot reaction of 7-isopropyl-1-methylazulene-4-carboxylic acid, diphenylphosphoryl azide, and an alcohol (MeOH, tBuOH or BnOH) affords the corresponding carbamates.
Kiriazis Alexandros, Aumuller Ingo, Yli-Kauhaluoma Jari   +2 more
openaire   +1 more source

Synthesis of spiro-annelated γ-lactams by isocyanide-based multicomponent reactions involving hem-disubstituted bifunctional reagents

Proceedings of The 17th International Electronic Conference on Synthetic Organic Chemistry, 2013
The new bifunctional hem-disubstituted alicyclic compounds IIIa-e and IVa-e were synthesized in several steps involving alkylation with allyl bromide following oxidative cleavage. Hem-disubstitues oxo-esters IIIa-e were introduced into azido-Ugi reaction followed by one-pot intramolucular bond formation to afford 3-(tetrazol-5-yl)-2-azaspiro[4.n]alkan ...
Vasiliy Stolyarenko, Ananatoliy Evdokimov, Vladimir Shishkin   +2 more
openaire   +1 more source

Bacterial production of carbapenems and clavams: evolution of β-lactam antibiotic pathways

Trends in Microbiology, 1998
Research into two of the four classes of naturally produced beta-lactams--the clavams and carbapenems--has started to throw light upon their biochemical pathways and underlying genetics. Interesting similarities between these two classes, from their joint discovery to an apparently common beta-lactam ring-forming enzyme, are now being revealed.
S J, McGowan, B W, Bycroft, G P, Salmond
openaire   +2 more sources

Clinical Evaluation of In Vitro Tests in Diagnosis of Immediate Allergic Reactions to β-Lactam Antibiotics

Allergy & Clinical Immunology International - Journal of the World Allergy Organization, 2002
María Sanz, P.M. Gamboa, A.L. de Weck
openaire   +1 more source

β-lactam antibiotics: An overview from a medicinal chemistry perspective

European Journal of Medicinal Chemistry, 2020
Gisele Barbosa, Lidia Moreira Lima, Eliezer J Barreiro   +2 more
exaly  

Current status of β-lactam antibiotic use and characterization of β-lactam-resistant Escherichia coli from commercial farms by integrated broiler chicken operations in Korea

Poultry Science, 2023
Young Ju Lee, Sunghyun Yoon
exaly  

Novel Hybrid Molecules Based on triazole-β-lactam as Potential Biological Agents

Mini-Reviews in Medicinal Chemistry, 2021
Pezhman Shiri
exaly  

Mn(III)-Promoted Sulfur-Directed 4-Exo-Trig Radical Cyclization of Enamides to β-Lactams

Tetrahedron, 1998
openaire   +1 more source

Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in Enterobacteriaceae

International Journal of Molecular Sciences, 2020
Brunella Posteraro, Mario Tumbarello, Maurizio Sanguinetti   +2 more
exaly