Results 231 to 240 of about 764,478 (294)

Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 7, July 2026.
ABSTRACT Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies for SSTIs. Additionally, we conduct population PK target attainment simulations for varying doses of cephalexin and cefadroxil for Staphylococcus ...
Jonathan H. Ryder, Shawnalyn W. Sunagawa, Nathaniel J. Rhodes, Trevor C. Van Schooneveld, Jeremy E. Tigh, Sean N. Avedissian, Nicolas Cortes‐Penfield   +6 more
wiley   +1 more source

Matrine Restores Porcine-Origin β-Lactam-Resistant <i>Escherichia coli</i> to Cefepime and Cefquinome: Association with Impaired Biofilm Formation and β-Lactamase Production. [PDF]

Antibiotics (Basel)
Yang B, Yang W, Hu B, Zhao J, Deng H, Yi L, Jian P, Hong Z, Yu D.   +8 more
europepmc   +1 more source

The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors

Protein Science, Volume 35, Issue 7, July 2026.
Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley   +1 more source

β-Lactam concentrations monitored in the early phase of community-acquired sepsis in the intensive care unit. [PDF]

J Antimicrob Chemother
Liljedahl Prytz K, Kryss E, Oxelbark J, Källman J, Nilsson KF, Sundqvist M, Savilampi J.   +6 more
europepmc   +1 more source

Systematic Review of Intravenous Ceftriaxone Administration in Animals

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
ABSTRACT Background Ceftriaxone is an antibiotic frequently prescribed in veterinary medical practice due to its effectiveness against several pathogenic microorganisms responsible for diseases in different animal species. Objective To select scientific articles from the academic databases PubMed and Web of Science that analysed the pharmacokinetic ...
Paula Maria Fernandes de Vasconcelos, Gabriel de Brito Rodrigues, Michel Leandro de Campos   +2 more
wiley   +1 more source

Simultaneous measurement of piperacillin, tazobactam and meropenem in patient samples using LC-MS/MS to support β-lactam therapeutic drug monitoring.

Anal Methods
Federico S, Williams S, Wilson RC, Arkel P, Gilchrist MJ, Holmes AH, Rawson TM, Riezk A.   +7 more
europepmc   +1 more source

Global response to antibiotic exposure reveals a critical role for nucleotide metabolism in high-level β-lactam tolerance. [PDF]

NPJ Antimicrob Resist
Keller MR, Kazi MI, Saleh A, Basu U, Shin JH, Rhee K, Dörr T.   +6 more
europepmc   +1 more source

Phenylalanine Versus Tyrosine (Pos. 367/332 in MCT1/MCT4) in the Substrate Binding Site Defines Affinity and Preferred Directionality of Human Monocarboxylate Transporters 1–4

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim Human monocarboxylate transporters 1–4, MCT, are key for the lactate/H+ exchange between glycolytic and oxidative cancer cells, white and red muscle fibers, or in the astrocyte‐neuron shuttle. The common MCT transport mechanism involves three conserved residues, that is, a substrate‐attracting Lys and a conformation‐locking Asp/Arg salt ...
Maike Menzel, Ioana‐Daniela Dumitru, Josh Peters, Jan‐Bernd Hövener, Andrey N. Pravdivtsev, Ana‐Nicoleta Bondar, Eric Beitz   +6 more
wiley   +1 more source