Results 241 to 250 of about 764,478 (294)

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

An enzymatic microfluidic sensor for β-lactam antibiotics based on cross-linked ancestral β-lactamase crystals. [PDF]

Nanoscale Adv
Rodríguez-Ruiz I, Moya-Garrido P, Risso VA, Martínez-Rodríguez S, Teychené S, Sanchez-Ruiz JM, Gavira JA.   +6 more
europepmc   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

Exploration of a benzothiophene scaffold for use as adjuvants with β-lactam antibiotics against methicillin-resistant <i>Staphylococcus aureus</i>. [PDF]

RSC Med Chem
Stefaniak MA, Gondil VS, Gillis EP, Nemeth AM, Oliver AG, Melander RJ, Dunman PM, Melander C.   +7 more
europepmc   +1 more source

Antibiotics in Veterinary Ophthalmology: Resistance, Stewardship, and Emerging Antibiotic‐Sparing Strategies

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Antimicrobial resistance (AMR) is a growing challenge in veterinary ophthalmology, particularly in cases of bacterial keratitis, where progressive stromal infection can threaten vision and globe integrity within hours to days. This review synthesizes current evidence on pathogen distribution, antimicrobial susceptibility profiles, multidrug ...
Lionel Sebbag, Oren Pe'er
wiley   +1 more source

A Circular and Tacticity‐Independent Crystalline Mono‐Substituted Nylon‐6 Platform: Unexpected Large Positional Effects on Crystallizability and Performance

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Methyl substitution positions on the nylon‐6 backbone markedly affect crystallizability, thermomechanical properties, and recyclability of the resulting atactic nylon‐6 variants. While γ‐methyl substitution gives an amorphous nylon, all other four methyl‐substitution positions (α, β, δ, and ε) afford, unexpectedly, crystalline nylons, showing tacticity‐
Jun‐Jie Tian, Jiyun Nam, Lili Wang, Andrea L. Baer, Ruirui Li, Maëlle T. Gace, Wei‐Feng Zheng, Clarissa Lincoln, Nicholas A. Rorrer, Eugene Y.‐X. Chen   +9 more
wiley   +2 more sources

Response to "The promise and pitfalls: interpreting dual β-lactam success in <i>Mycobacterium abscessus</i> with caution". [PDF]

ASM Case Rep
Dousa KM, Bonomo RA.
europepmc   +1 more source

Electrochemical Sensor Based on Molecularly Imprinted Polymer for Cefuroxime Detection in Biological and Environmental Samples

ChemElectroChem, Volume 13, Issue 12, 17 June 2026.
A highly sensitive electrochemical sensor for cefuroxime (CFR) is developed using a molecularly imprinted PEDOT film integrated with AuNPs and MXene on MWCNT‐SPE. The platform enables selective detection down to nanomolar levels and performs reliably in complex matrices, offering a promising approach for rapid monitoring of antibiotic residues in ...
Houda Essousi, Bogdan Feier, Mihaela Tertis, Maria Suciu, Jassem Wannassi, Houcine Barhoumi, Cecilia Cristea   +6 more
wiley   +1 more source

Synergistic Potential of Repurposing non-β-lactam Compounds as Class A serine β-lactamases Inhibitor: Insights from MolecularDocking, Molecular Dynamics Simulations and Antimicrobial Potentiation. [PDF]

Sci Rep
Abdalla MS, Dutta S, Sulieman MO, Jaber AA, Noorelhuda MO, Elkhidir OF, Sardar S, Hajhamed NM, Awad TA, Mustafa SA, Lee SG, Aldin NAM.   +11 more
europepmc   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source