Results 241 to 250 of about 144,498 (294)

Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT Biofilms formed by mycobacteria, particularly Mycobacterium tuberculosis (Mtb), represent a major challenge in tuberculosis (TB) treatment due to their highly organized structure and their capacity to induce phenotypic drug tolerance. These three‐dimensional bacterial aggregates are embedded in a self‐produced extracellular matrix that ...
Lourdes Serrano Garcia, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan, Marlus Chorilli   +3 more
wiley   +1 more source

Urticaria-Like Hypersensitivity Reaction Following Botulinum Toxin Injection: A Case Report of Possible Interaction with β-Lactam Antibiotics. [PDF]

Int Med Case Rep J
Feng W, Liu H.
europepmc   +1 more source

Analysis of Human miRNA Derived From Bladder Epithelial Cells Infected With Uropathogenic Escherichia coli

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT MicroRNAs (miRNAs) have been shown to regulate many cellular processes and to play a role in host‐pathogen interactions. However, the role of miRNA in urinary tract infection (UTI) remains unclear. The aim of this study was to analyze and compare miRNAs from supernatants of human bladder epithelial cells infected with ESBL‐producing (ESBL019 ...
Katarina Persson, Isak Demirel, Ignacio Rangel, Robert Kruse   +3 more
wiley   +1 more source

Study on the chemical stability of β-lactam antibiotics in concomitant simple suspensions with magnesium oxide. [PDF]

J Pharm Health Care Sci
Kato G, Mitome H, Takeda S, Hidaka N, Tanaka M, Akira K.   +5 more
europepmc   +1 more source

Review Article: Classic Bismuth Quadruple Therapy for Helicobacter pylori Infection—Questions Focused on Clinical Practice

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 5, Page 616-636, March 2026.
BQT remains the most effective, safe, and practical regimen for H. pylori eradication, ensuring high cure rates across diverse resistance patterns and clinical settings. ABSTRACT Background Classic bismuth quadruple therapy (BQT)—the combination of a proton pump inhibitor, bismuth, tetracycline, and metronidazole—is a standard regimen for treating ...
Javier P. Gisbert, Pablo Parra, Olga P. Nyssen   +2 more
wiley   +1 more source

The Clinical Impact of Antibiotic Allergy Labels on One‐Year Outcomes of Solid Organ Transplant Recipients

Clinical Transplantation, Volume 40, Issue 3, March 2026.
ABSTRACT Antibiotic allergy labels (AALs) are common and often incorrect. They have many potential impacts, including the use of broader‐spectrum antibiotics and suboptimal treatment of infections. The impact of inaccurate allergy labels on post‐transplant outcomes in the solid organ transplant population is not well described.
Sashi Niranjan Nair, Paul Bigliardi, Lauren Fontana   +2 more
wiley   +1 more source

Evaluation of Drug–Drug Interaction Potential Between the Oral Antibiotic Zoliflodacin and the CYP3A4 Inhibitor Itraconazole: A Phase 1 Study in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Zoliflodacin is a first‐in‐class oral spiropyrimidinetrione antibiotic being developed for patients with uncomplicated gonorrhea, including those infected with multidrug‐resistant strains. Because zoliflodacin is metabolized by cytochrome P450 3A4 (CYP3A4), concomitant administration with a CYP3A inhibitor has the potential to increase ...
Alison Luckey, Kajal B. Larson, Noha Rayad, Markus Heep, Sophie Delhomme, Gabrielle Kornmann, John P. Mueller, John P. O'Donnell, Seamus O'Brien, Rainard Fuhr, Jean‐Yves Gillon   +10 more
wiley   +1 more source

Mechanistic insights into the multitarget synergistic efficacy of farrerol and β-lactam antibiotics in combating methicillin-resistant <i>Staphylococcus aureus</i>. [PDF]

Antimicrob Agents Chemother
Yu H, Wang L, Liu X, Zheng J, Xiang H, Zheng Y, Lv D, Yang J, Zhang Y, Qiu J, Wang D.   +10 more
europepmc   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, Volume 293, Issue 6, Page 1587-1611, March 2026.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Navigating pharmacokinetic and pharmacodynamics challenges of β-lactam antibiotics in patients with low body weight: efficacy, toxicity, and dosage optimization. [PDF]

Ther Adv Drug Saf
Tseng YJ, Tai CH, Chen GY, Chen YL, Ku SC, Pai TY, Wu CC.   +6 more
europepmc   +1 more source