Results 251 to 260 of about 144,498 (294)

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

The FEBS Journal, Volume 293, Issue 6, Page 1801-1817, March 2026.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska, Anna Koczurowska, Marta Orlikowska, Maciej Nielipinski, Dominika Nielipinska, Bartosz Sekula   +5 more
wiley   +1 more source

Restoring susceptibility to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus. [PDF]

Nat Chem Biol
Nguyen VT, Birhanu BT, Miguel-Ruano V, Kim C, Batuecas M, Yang J, El-Araby AM, Jiménez-Faraco E, Schroeder VA, Alba A, Rana N, Sader S, Thomas CA, Feltzer R, Lee M, Fisher JF, Hermoso JA, Chang M, Mobashery S.   +18 more
europepmc   +1 more source

Sex Differences in Lung Immunity

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Biological sex has a significant impact on how the immune system develops and responds to foreign and self‐antigens. Sex differences exist in innate and adaptive immune cells, both at homeostasis and in the context of infection and inflammatory diseases such as asthma, cancer, and autoimmune disorders.
Franz Puttur, Clare M. Lloyd
wiley   +1 more source

(p)ppGpp and DksA play a crucial role in reducing the efficacy of β-lactam antibiotics by modulating bacterial membrane permeability. [PDF]

Microbiol Spectr
Chawla M, Verma J, Kumari S, Matta T, Senapati T, Babele P, Kumar Y, Bhadra RK, Das B.   +8 more
europepmc   +1 more source

The Need for a Revision of Fluoroquinolone Breakpoints for Interpretation of Antimicrobial Susceptibility Testing of Feline Bacterial Isolates

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 2, Page 131-140, March 2026.
ABSTRACT The fluoroquinolone antimicrobial agents, enrofloxacin and marbofloxacin, were approved in the United States for cats in 1990 and 2001, respectively. In 2023, revised breakpoints for testing isolates from dogs were published. These canine breakpoints are discordant with the current feline breakpoints.
Mark G. Papich, Lacie A. Gunnett, Marilyn N. Martinez   +2 more
wiley   +1 more source

The A226D Mutation of OmpC Leads to Increased Susceptibility to β-Lactam Antibiotics in Escherichia coli. [PDF]

Biology (Basel)
Zhu J, Guo P, Zheng Y, Xiang S, Zhao Y, Liu X, Fu C, Zhang Y, Xu H, Li L, Wang W, Wang M.   +11 more
europepmc   +1 more source

Risk Factors for Antibiotic‐Associated Diarrhoea in Paediatric Patients With Severe Pneumonia: A Retrospective Cohort

Nursing in Critical Care, Volume 31, Issue 2, March 2026.
ABSTRACT Background Severe pneumonia in paediatric patients typically necessitates prolonged courses of antibiotic therapy, a practice that elevates vulnerability to antibiotic‐associated diarrhoea (AAD). Aim The present study aimed to evaluate the clinical profiles of paediatric patients with AAD secondary to severe pneumonia and to explore evidence ...
Shuang Gao, Ya Dan, Xuemei Liu, Ruxin Tang, Gengqin Wang   +4 more
wiley   +1 more source

Group A streptococcus isolated in Guyana with reduced susceptibility to β-lactam antibiotics. [PDF]

Access Microbiol
Kalladeen M, Cheddie P, Akpaka PE.
europepmc   +1 more source

The Future of β-Lactam Antibiotics [PDF]

, 2017
Waldvogel, Francis A.
core  

Direct single dose mass delabelling of antibiotic allergy in pediatrics

Pediatric Allergy and Immunology, Volume 37, Issue 3, March 2026.
Abstract Background Unsubstantiated antibiotic allergy labels affect between 8% and 25% of the population worldwide. Current risk stratification tools, derived from adult data, are not validated for children. A simplified, multi‐patient protocol with minimal exclusion criteria is required to tackle the scale of this public health issue.
Sheena Coyne, Aideen Byrne, Amber Gill, Davina Henderson, Kara Tedford, Victoria Mc Donald, Helen O'Connor, Catherine Breen, Aisling Stafford, Maeve Kelleher, David Coghlan, Jonathan Hourihane   +11 more
wiley   +1 more source