Results 271 to 280 of about 144,498 (294)

A guide to therapeutic drug monitoring of β‐lactam antibiotics

Pharmacotherapy, 2021
Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug classes in the hospital setting.
A. Fratoni, D. Nicolau, J. Kuti
semanticscholar   +1 more source

β-Lactam antibiotics and antibiotic resistance in Asian lakes and rivers: An overview of contamination, sources and detection methods.

Environmental Pollution, 2021
Lakes and rivers are sources of livelihood, food and water in many parts of the world. Lakes provide natural resources and valuable ecosystem services. These aquatic ecosystems are also vulnerable to known and new environmental pollutants. Emerging water
Katrina Marie Sta Ana, Jonalyn Madriaga, M. Espino   +2 more
semanticscholar   +1 more source

Evanescent Wave Optical Fiber Sensors Using Enzymatic Hydrolysis on Nanostructured Polyaniline for Detection of β-Lactam Antibiotics in Food and Environment.

Analytical Chemistry, 2021
β-Lactam antibiotics such as penicillins and cephalosporins are extensively used for human infection therapy. Consistent unintended exposure to these antibiotics via food and water is known to promote antibiotic-resistant bacterial pathogenesis with high
P. Nag, Kapil Sadani, Sanjeeb Mohapatra, S. Mukherji, S. Mukherji   +4 more
semanticscholar   +1 more source

β-lactam antibiotics: An overview from a medicinal chemistry perspective.

European journal of medicinal chemistry, 2020
β-Lactam antibiotics are one of the most relevant drug classes of antibacterial agents worldwide. The discovery and the market of first β-lactam antibiotic (Penicillin G) is a symbolic landmark of modern chemotherapy.
L. M. Lima, B. Silva, Gisele Barbosa, E. Barreiro   +3 more
semanticscholar   +1 more source

Using Aspergillus niger whole-cell biocatalyst mycelial aerobic granular sludge to treat pharmaceutical wastewater containing β-lactam antibiotics

, 2021
Pharmaceutical wastewater is usually complex and highly toxic, mostly containing antibiotics. The conventional activated sludge technology is unsatisfactory in the treatment of pharmaceutical wastewater owing to the impact of antibiotic toxicity. In this
Jing Ji, Tianpeng Gao, El-Sayed Salama, M. El-Dalatony, Liang Peng, Yuxing Gong, Pu Liu, Xiangkai Li   +7 more
semanticscholar   +1 more source

Bacterial production of carbapenems and clavams: evolution of β-lactam antibiotic pathways

Trends in Microbiology, 1998
Research into two of the four classes of naturally produced beta-lactams--the clavams and carbapenems--has started to throw light upon their biochemical pathways and underlying genetics. Interesting similarities between these two classes, from their joint discovery to an apparently common beta-lactam ring-forming enzyme, are now being revealed.
S J, McGowan, B W, Bycroft, G P, Salmond
openaire   +2 more sources

Therapeutic drug monitoring of β-lactam antibiotics in the ICU

Expert Review of Anti-Infective Therapy, 2020
Introduction Individualizing antibiotic therapy is paramount to improve clinical outcomes while minimizing the risk of toxicity and antimicrobial therapy. β-lactam antibiotics are amongst the drugs most commonly prescribed in the Intensive Care Unit (ICU)
S. Dhaese, S. Van Vooren, J. Boelens, J. D. De Waele   +3 more
semanticscholar   +1 more source

Photolysis of four β‑lactam antibiotics under simulated environmental conditions: Degradation, transformation products and antibacterial activity.

Science of the Total Environment, 2019
β‑Lactam antibiotics are among the most widely used antibiotics in human medicine and their effects on the aquatic environment - concerning bacterial resistance - are controversially discussed.
Alexander Timm, Ewa Borowska, M. Majewsky, S. Merel, C. Zwiener, Stefan Bräse, H. Horn   +6 more
semanticscholar   +1 more source

Can β-Lactam Antibiotics Be Resurrected to Combat MRSA?

Trends in Microbiology, 2019
The use of β-lactam antibiotics to treat infections caused by Staphylococcus aureus has been severely compromised by the acquisition by horizontal gene transfer of a gene that encodes the β-lactam-insensitive penicillin-binding protein PBP2a. This allows
T. Foster
semanticscholar   +1 more source