Results 141 to 150 of about 2,697,911 (252)

Challenges in transfusion and the role of Thalidomide in E‐β‐Thalassemia—A case report

, 2020
Hemoglobin E-β-thalassemia is a common β-thalassemia that has a variable presentation from mild to severe life-threatening anemia. We describe such a case, who presented with severe anemia and multiple allo-antibodies.
Rizwan Javed, Chandy, Mammen, Mammen Chandy, Vivek Radhakrishnan, Javed, Rizwan, Sabita Basu, Basu, Sabita, Radhakrishnan, Vivek   +7 more
core   +1 more source

Phosphoproteomic analysis of apoptotic hematopoietic stem cells from hemoglobin E/β-thalassemia [PDF]

, 2011
Background Hemoglobin E/β-thalassemia is particularly common in Southeast Asia and has variable symptoms ranging from mild to severe anemia. Previous investigations demonstrated the remarkable symptoms of β-thalassemia in terms of the acceleration of ...
Sresanga Kitima, Ponnikorn Saranyoo, Chokdee Wongborisuth, Sumalee Tungpradabkul, Tasanee Panichakul, Hongeng Suradej, Panichakul Tasanee, Suradej Hongeng, Kitima Sresanga, Saranyoo Ponnikorn, Tungpradabkul Sumalee, Roytrakul Sittiruk, Wongborisuth Chokdee, Sittiruk Roytrakul   +13 more
core   +1 more source

Differentiating β‐Thalassaemia From Iron Deficiency: Performance and Cut‐Off Dependency of More Than 40 Red Cell Discrimination Indices in a Large German Cohort

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Since the 1970s, more than 40 red blood cell–based formulas have been proposed to differentiate β‐thalassaemia trait (BTT) from iron deficiency (ID) and iron deficiency anaemia (IDA), the main causes of microcytic anaemia. In Germany, where haemoglobinopathies are rare in the autochthonous population but increasingly encountered due
Rafid Al‐Nabhan, Dani Hakimeh, Lena Oevermann   +2 more
wiley   +1 more source

PBI22 Rethinking the Health-Economic Evaluation Framework for GENE Therapies: The Betibeglogene Autotemcel (BETI-CEL) Case in Î’-Thalassemia [PDF]

Value in Health, 2020
L. Undreiner, M. Caillon, C. Paramore, S. Roze   +3 more
openaire   +1 more source

A retrospective analysis of the antigen‐negative red blood cell supply conducted at a single centre in China

Transfusion Medicine, EarlyView.
Abstract Objective This study aimed to analyse the distribution and demand patterns of antigen‐negative red blood cells (RBCs) in Shandong Province, China (2022–2024), with a focus on ABO blood groups and clinically significant antigens. The research was designed to provide rigorous data for advancing precision transfusion protocols and to establish a ...
Aiping Zhao, Xiujiao Jiang, Li An, Yuanfeng Chen, Weidong He, Qun Xu, Wenchao Li, Yingfang Pan   +7 more
wiley   +1 more source

Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients

, 2017
Key PointsAberrant neutrophil maturation is associated with reduced effector functions in β-thalassemia. PU.1, the key regulator of terminal neutrophil maturation, is dysregulated in β-thalassemia.
Bradley McColl, Jim Vadolas, Jurre Ynze Siegers, Suthat Fucharoen, Saovaros Svasti, Panjaree Siwaponanan, Razi Ghazali, Odilia Wijburg, Nancy Wang, Garrett Zhen-Wei Ng, Chayada Thiengtavor, Philip Sutton, Thian Ng, Isabelle Ooi, Pornthip Chaichompoo   +14 more
core   +1 more source

Association of α globin gene quadruplication and heterozygous β thalassemia in patients with thalassemia intermedia

Haematologica, 2009
Ten patients with thalassemia intermedia with variable severity and apparent simple heterozygosis for β0 39 C>T nonsense mutation were submitted to clinical, hematologic and molecular studies.
Maria Carla Sollaino, Maria Elisabetta Paglietti, Lucia Perseu, Nicolina Giagu, Daniela Loi, Renzo Galanello   +5 more
doaj   +1 more source

Iron metabolism under conditions of ineffective erythropoiesis in β-thalassemia.

Blood, 2019
β-Thalassemia (BT) is an inherited genetic disorder that is characterized by ineffective erythropoiesis (IE), leading to anemia and abnormal iron metabolism.
S. Rivella
semanticscholar   +1 more source

Knockdown of mitotically associated long non‐coding RNA dysregulates endothelial functions, transcriptome and proteome

The Journal of Physiology, EarlyView.
Abstract figure legend Downregulation of mitotically associated long non‐coding RNA (MANCR) disturbs transcriptome and proteome in endothelial cells, possibly leading to endothelial and vascular dysfunction in preeclampsia. Abstract Preeclampsia (PE) is a hypertensive disorder during pregnancy, which is characterized by a wide spectrum of endothelial ...
Si‐Yan Zhang, Chi Zhou, Jing Zheng
wiley   +1 more source

Correction of RNA splicing defect in β(654)-thalassemia mice using CRISPR/Cas9 gene-editing technology

, 2021
β(654)-thalassemia is a prominent Chinese subtype of β-thalassemia, representing 17% of all cases of β-thalassemia in China. The molecular mechanism underlying this subtype involves the IVS-2-654 C→T mutation leading to aberrant β-globin RNA splicing ...
Yanwen Chen, Yudan Fang, Qingwen Ma, Yitao Zeng, Lu, Dan, Xinbing Guo, Fang, Yudan, Dan Lu, Xiuli Gong, Ma, Qingwen, Guo, Xinbing, Gong, Xiuli, Chen, Yanwen, Fanyi Zeng, Guijun Zhao, Yang, Fan, Zhao, Guijun, Zeng, Yitao, Zeng, Fanyi, Fan Yang   +19 more
core   +1 more source