Results 121 to 130 of about 2,697,911 (252)

β-thalassemia major evolution from β-thalassemia minor is associated with paternal uniparental isodisomy of chromosome 11p15

Haematologica, 2008
β-thalassemia major can be caused by homozygosity or compound heterozygosity for β-globin gene mutations (HBB gene). Most cases are inherited from parents who both have diseased alleles of the HBB gene.
Jan-Gowth Chang, Wen-Chan Tsai, Inn-Wen Chong, Chao-Sung Chang, Chyi-Chang Lin, Ta-Chih Liu   +5 more
doaj   +1 more source

Carrying a crisis: The risk of a painful sickle cell crisis during pregnancy

British Journal of Haematology, EarlyView.
Commentary on: Auger et al. Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes. Br J Haematol 2026 (Online ahead of print). doi: 10.1111/bjh.70837.
Bart J. Biemond
wiley   +1 more source

Chronic hyperplastic anemia as an independent risk factor for atherosclerotic lesions: a lesson from thalassemia intermedia [PDF]

, 2010
Introduction. Cardiovascular involvement represents a well-known complication and the primary cause of mortality, both in transfusion-dependent beta thalassemia major (β-TM) and in transfusion-independent beta thalassemia intermedia (β-TI ...
Pier Luigi Cocco, Alessandra Spiga, Fabrizio Angius, Stefania Vacquer, Maria Eliana Lai, Antonella Mandas, Maria Paola Carta, Sandra Dessi   +7 more
core  

Mutational analysis of the Janus kinase II (V617F) gene in patients with β-Thalassemia major

Zanco Journal of Pure and Applied Sciences, 2020
β-Thalassemia is a group of congenital hemolytic anemia that characterized by the underproduction of the indispensable hemoglobin molecule, the oxygen and carbon dioxide carrying protein inside the red cells.
Salar Adnan Ahmed
doaj   +1 more source

Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes

British Journal of Haematology, EarlyView.
Summary We assessed the pregnancy outcomes of patients with sickle cell crises. We carried out a retrospective study of 2 698 556 pregnancies in Quebec, Canada between 1989 and 2022. The primary exposure was sickle cell anaemia with crisis during or outside of pregnancy. Outcomes included severe maternal morbidity and other pregnancy complications.
Nathalie Auger, Émilia Mailhot‐Diaferia, Gabriel Côté‐Corriveau, Gilles Paradis, Antoine Lewin, Aimina Ayoub, Anne‐Marie Parrot, Ashley Park, Brian Potter   +8 more
wiley   +1 more source

Diabetes mellitus in β-thalassemia major patients

, 2003
β-thalassemia major is a disease caused by β polypeptide chain synthesis disorder which is inherited as an autosomal recessive from both parents which is marked by little or no β globin chain synthesis.
Setiawan, Santy, Munthe, Bulan G., Kusnandar, Simon, Wirawan, Riadi   +3 more
core   +1 more source

Metabolic syndrome in Iraqi female patients with major β-thalassemia [PDF]

, 2017
Patients with β-thalassemia may have an increased risk for diabetes mellitus and cardiovascular diseases due to high level of iron which may lead to insulin resistanceand metabolic syndrome. So this study aimed to evaluate the levels of lipids profile in
Shaemaa Hadi Abdulsada, Salma Abdul-Rudha, Aliaa Hashim Farag, Hassanain Kamil, Ali Abdulrassol Hussein   +4 more
core   +1 more source

Analysis of Common Alpha-Globin Gene Abnormalities and Their Effects as Genetic Modifiers in Thai Children With β-Globin Gene Abnormalities

Anemia
Beta-thalassemia exhibits a broad phenotypic range influenced by the severity of HBB mutation and various genetic modifiers. One of the most essential modifiers is the coinheritance of α-globin gene mutation.
Sethapong Lertsakulbunlue, Boonchai Boonyawat, Chanchai Traivaree, Apichat Photia   +3 more
doaj   +1 more source

Predicting factors of survival rates among alpha- and beta-thalassemia patients: a retrospective 10-year data analysis

Frontiers in Hematology
BackgroundThalassemia is a genetic hemoglobinopathy in which a defective globin chain can cause transfusion-dependent anemia and other complications.
Kunapa Iam-arunthai, Tawatchai Suwanban, Pravinwan Thungthong, Supat Chamnanchanunt, Supat Chamnanchanunt, Suthat Fucharoen   +5 more
doaj   +1 more source

KETERKAITAN JUMLAH DAERAH TERMUTASI PADA GEN β-GLOBIN DENGAN INDEKS KORPUSKULAR PEMBAWA SIFAT β-THALASSEMIA

Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH), 2016
Thalassemia is a genetic disorder caused by point mutations on the globin gene that decrease the corpuscular index in thalassemia carriers. Three to five percent of Indonesians are thalassemia carriers, with β-thalassemia being the most common type. This
Priyambodo Priyambodo
doaj   +1 more source