Results 231 to 240 of about 145,582 (253)

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface

The Journal of Physiology, EarlyView.
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista, Declan Manning, Emily C. Lieu, Stephanie I. Ugochukwu, Collin Matsumoto, Joshua P. Tulman, Miguel Martin‐Aragon Baudel, Nuria Daghbouche‐Rubio, Steven J. McElroy, Sal A. Baker, Manuel F. Navedo, L. Fernando Santana   +11 more
wiley   +1 more source

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Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions

Nature Reviews Molecular Cell Biology, 2022
Pakorn Kanchanawong, David A Calderwood
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The final steps of integrin activation: the end game

Nature Reviews Molecular Cell Biology, 2010
Mark H Ginsberg, Sanford J Shattil, Chungho Kim   +2 more
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Integrins as biomechanical sensors of the microenvironment

Nature Reviews Molecular Cell Biology, 2019
Pere Roca-cusachs, Jenny Z Kechagia, Johanna Ivaska   +2 more
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The integrin adhesome: from genes and proteins to human disease

Nature Reviews Molecular Cell Biology, 2014
Benjamin Geiger, Reinhard Fässler, Kyle R. Legate   +2 more
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Integrin's new partner

Nature Reviews Molecular Cell Biology, 2010
Kim Baumann
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Integrins in cancer: biological implications and therapeutic opportunities

Nature Reviews Cancer, 2010
Jay S Desgrosellier
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The 'ins' and 'outs' of integrin signalling

Nature Reviews Molecular Cell Biology, 2013
Katharine Wrighton
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