Results 1 to 10 of about 52,699 (120)

Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles [PDF]

Journal of Cell Biology, 2019
ABSTRACT Receptor tyrosine kinases (RTKs) are important cargo in endocytic trafficking, yet their role in endosomal sorting and maturation of multivesicular bodies (MVBs) remains unclear. Here we show that the ErbB3 receptor sorts internalised Integrin β1, and the transferrin receptor (TfR), for endocytic recycling, in a manner that ...
Dorival Mendes Rodrigues-Junior, Ana Rosa Sáez-Ibáñez, Takeshi Terabayashi, Nina Daubel, Taija Mäkinen, Olof Idevall-Hagren, Aristidis Moustakas, Ingvar Ferby   +7 more
openaire   +5 more sources

The characteristics and the multiple functions of integrin β1 in human cancers [PDF]

Journal of Translational Medicine, 2023
Integrins, which consist of two non-covalently linked α and β subunits, play a crucial role in cell–cell adhesion and cell-extracellular matrix (ECM) interactions.
Li Sun, Shuwei Guo, Yiping Xie, Yongliang Yao   +3 more
doaj   +2 more sources

Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cancer [PDF]

Scientific Reports
Curcumin has attracted attention for its nontoxic chemopreventive effects; however, the pathways underlying these effects in colon cancer remain unclear. We investigated the potential interplay between curcumin and integrin β1 in colon cancer.
Hyeon Kyeong Kim, Ryung-Ah Lee, Kyung Sook Hong, Gyoung Tae Noh, Bo Young Oh   +4 more
doaj   +2 more sources

Hepatokine FGL1 drives endothelial injury and atherogenesis via integrin β1-mediated endothelial–mesenchymal transition [PDF]

Acta Pharmaceutica Sinica B
Atherosclerosis is driven by metabolic dysregulation and endothelial dysfunction; however, the precise molecular mechanisms underlying its pathogenesis remain incompletely elucidated. Fibrinogen-like protein 1 (FGL1) is a well-established hepatokine with
Yixiu Zhao, Huan Chen, Liuqing Yin, Ruirui Meng, Jiangfei Zheng, Yue Zhang, Zhiqi Wang, Yi Chen, Rui Xu, Jing Liu, Yanxi Li, Na An, Houwei Li, Yan Zhang   +13 more
doaj   +2 more sources

Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity [PDF]

iScience
Summary: Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability and proliferation in cancer and inflammatory diseases but remains poorly understood.
Adama Sidibé, Vasyl V. Mykuliak, Pingfeng Zhang, Vesa P. Hytönen, Jinhua Wu, Bernhard Wehrle-Haller   +5 more
doaj   +2 more sources

Vimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis [PDF]

BMC Biology
Background The intermediate filament protein vimentin is widely recognized as a molecular marker of epithelial-to-mesenchymal transition. Although vimentin expression is strongly associated with cancer metastatic potential, the exact role of vimentin in ...
Jiyoung Jang, Hyun Jung Park, Wonyoung Seong, Jiyoon Kim, Chungho Kim   +4 more
doaj   +2 more sources

Delayed cortical development in mice with a neural specific deletion of β1 integrin

Frontiers in Neuroscience, 2023
The adhesion systems employed by migrating cortical neurons are not well understood. Genetic deletion studies of focal adhesion kinase (FAK) and paxillin in mice suggested that these classical focal adhesion molecules control the morphology and speed of ...
Mamunur Rashid, Mamunur Rashid, Eric C. Olson   +2 more
doaj   +1 more source

Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice

Journal of Orthopaedic Translation, 2022
Background: The key focal adhesion protein β1 integrin plays an essential role in early skeletal development. However, roles of β1 integrin expression in osteocytes during the regulation of bone homeostasis and mechanotransduction are incompletely ...
Lei Qin, Tailin He, Dazhi Yang, Yishu Wang, Zhenjian Li, Qinnan Yan, Peijun Zhang, Zecai Chen, Sixiong Lin, Huanqing Gao, Qing Yao, Zhen Xu, Bin Tang, Weihong Yi, Guozhi Xiao   +14 more
doaj   +1 more source

β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. [PDF]

PLoS ONE, 2013
β1 integrin regulates multiple epithelial cell functions by connecting cells with the extracellular matrix (ECM). While β1 integrin-mediated signaling in murine epithelial stem cells is well-studied, its role in human adult epithelial progenitor cells ...
Nancy Ernst, Arzu Yay, Tamás Bíró, Stephan Tiede, Martin Humphries, Ralf Paus, Jennifer E Kloepper   +6 more
doaj   +1 more source

Effective treatment of HER2-amplified breast cancer by targeting HER3 and β1 integrin [PDF]

Breast Cancer Research and Treatment, 2016
The central role of HER2 as the disease driver and HER3 as its essential partner has made them rational targets for the treatment of HER2-amplifed breast cancers, and there is considerable interest in developing highly effective treatment regimens for this disease that consist of targeted therapies alone.
Campbell, Marcia R, Zhang, Hui, Ziaee, Shabnam, Ruiz-Saenz, Ana, Gulizia, Nathaniel, Oeffinger, Julie, Amin, Dhara N, Ahuja, Deepika, Moasser, Mark M, Park, Catherine C   +9 more
openaire   +4 more sources