Results 41 to 50 of about 56,023 (262)

Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress

Cellular Physiology and Biochemistry, 2015
Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang, Chunhui Zhu, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Qijia Zhou, Shun Xu, Chenjun Zhai, Weimin Fan   +9 more
doaj   +1 more source

Ligand-independent integrin β1 signaling supports lung adenocarcinoma development

JCI Insight, 2022
Integrins — the principal extracellular matrix (ECM) receptors of the cell — promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis.
Scott M. Haake, Erin J. Plosa, Jonathan A. Kropski, Lindsay A. Venton, Anupama Reddy, Fabian Bock, Betty T. Chang, Allen J. Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A. Prather, Sharon Lee, Harikrishna Tanjore, Vasiliy V. Polosukhin, Olga M. Viquez, Angela Jones, Wentian Luo, Matthew H. Wilson, W. Kimryn Rathmell, Pierre P. Massion, Ambra Pozzi, Timothy S. Blackwell, Roy Zent   +22 more
doaj   +1 more source

Analysis of the expression and prognostic value of MT1-MMP, β1-integrin and YAP1 in glioma

Open Medicine, 2022
Increased expression of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) is associated with the development of many cancers. MT1-MMP may promote the entry of yes-associated protein1 (YAP1) into the nucleus by regulating the regulation of β1 ...
Zhai Yangyang, Sang Wei, Su Liping, Shen Yusheng, Hu Yanran, Zhang Wei   +5 more
doaj   +1 more source

Atomic Force Microscopy-Based Nanoscopy of Chondrogenically Differentiating Human Adipose-Derived Stem Cells: Nanostructure and Integrin β1 Expression

Nanoscale Research Letters, 2018
Integrin β1 is known to be involved in differentiation, migration, proliferation, wound repair, tissue development, and organogenesis. In order to analyze the binding probability between integrin β1 ligand and cluster of differentiation 29 (CD29 ...
Jie Yang, Ming-Tang He, Xun Huang, Qiu-Shi Wang, Jiang Pi, Hua-Jun Wang, Ali Hasan Rahhal, Si-Min Luo, Zhen-Gang Zha   +8 more
doaj   +1 more source

MOESM1 of Lipid-rafts remain stable even after ionizing radiation induced disintegration of β1 integrin containing focal adhesions

, 2017
Additional file 1. Additional information. Details of experimental procedure and Additional figures S1, S2 and S3.
Babel, Laura, Kruse, Larissa, Bump, Steven, Langhans, Markus, Meckel, Tobias   +4 more
openaire   +1 more source

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.

, 2012
Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell ...
Valderrama, F, Riou, P, Muschel, Ruth, Susan Cox, Garg, Ritu, Vega, FM, Im, Jae Hong, Im, JH, Valderrama, Ferran, Ritu Garg, Muschel, Ruth J, Ridley, Anne J, Garg, R, Cox, Susan, Barbara Borda d’Agua, Cox, S, Vega, Francisco M., d'Agua, Barbara Borda, Reymond, N, Nicolas Reymond, Philippe Riou, Borda d'Agua, Barbara, Ferran Valderrama, Reymond, Nicolas, Jae Hong Im, Riou, Philippe, Muschel, Ruth J., Borda d'Agua, B, Ridley, AJ, Francisco M. Vega, Muschel, RJ, Anne J. Ridley, Ridley, Anne J., Vega, Francisco M, Ruth J. Muschel   +34 more
core   +1 more source

PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas

iScience, 2020
Summary: Identifying the specific functional regulator of integrin family molecules in cancer cells is critical because they are directly involved in tumor invasion and metastasis.
Yushi Ueki, Ken Saito, Hidekazu Iioka, Izumi Sakamoto, Yasuhiro Kanda, Masakiyo Sakaguchi, Arata Horii, Eisaku Kondo   +7 more
doaj   +1 more source

Additional file 1: of The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration

, 2019
Figure S1. Small vesicles containing CD93 colocalize with caveolin-1 in early spreading ECs. Figure S2. Disruption of the actin cytoskeleton impairs CD93 intracellular trafficking. Figure S3. Microtubule cytoskeleton disruption has no effects on CD93 intracellular trafficking. Figure S4.
Barbera, Stefano, Nardi, Federica, Elia, Ines, Realini, Giulia, Lugano, Roberta, Santucci, Annalisa, Tosi, Gian, Dimberg, Anna, Galvagni, Federico, Orlandini, Maurizio   +9 more
openaire   +1 more source

Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity. [PDF]

iScience
Summary: Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability and proliferation in cancer and inflammatory diseases but remains poorly understood.
Sidibé A, Mykuliak VV, Zhang P, Hytönen VP, Wu J, Wehrle-Haller B.   +5 more
europepmc   +2 more sources

β1インテグリン/FAKシグナル伝達経路は、ヒト歯肉上皮細胞株 Ca9-22細胞におけるインターロイキン-8の産生を調節する [PDF]

大阪歯科大学Osaka Dental University博士（歯学）Interleukin-8 (IL-8), one of the proinflammatory factors in human tissues, plays an important role in inflammation. Type IV collagen, a key component of the basement membrane, interacts with integrins, which are primary
母, 梅力, Mu, Meili, ボ, バイリキ   +2 more
core   +1 more source